LEAP2 protein (human) - STRING database

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

LEAP2

Liver-expressed antimicrobial peptide 2; Has an antimicrobial activity (77 aa)

Predicted Functional Partners:

HAMP

0.755

VGF

0.582

FOLR2

0.535

CLDN12

0.471

PHKA2

0.461

ATRN

0.438

VSTM2L

0.434

CTXN1

0.429

SALL3

0.428

PHKA1

0.407

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATRN	LEAP2	ENSP00000262919	ENSP00000296877	Attractin; Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti (By similarity). Has a critical role in normal myelination in the central nervous system (By similarity); C-type lectin domain containing	Liver-expressed antimicrobial peptide 2; Has an antimicrobial activity	0.438
CLDN12	LEAP2	ENSP00000287916	ENSP00000296877	Claudin-12; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins	Liver-expressed antimicrobial peptide 2; Has an antimicrobial activity	0.471
CTXN1	LEAP2	ENSP00000313226	ENSP00000296877	Cortexin-1; May mediate extracellular or intracellular signaling of cortical neurons during forebrain development	Liver-expressed antimicrobial peptide 2; Has an antimicrobial activity	0.429
CTXN1	VSTM2L	ENSP00000313226	ENSP00000362560	Cortexin-1; May mediate extracellular or intracellular signaling of cortical neurons during forebrain development	V-set and transmembrane domain-containing protein 2-like protein; V-set and transmembrane domain containing 2 like	0.612
FOLR2	LEAP2	ENSP00000298223	ENSP00000296877	Folate receptor beta; Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release	Liver-expressed antimicrobial peptide 2; Has an antimicrobial activity	0.535
HAMP	LEAP2	ENSP00000471894	ENSP00000296877	Hepcidin; Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma- absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes; Belongs to the hepcidin family	Liver-expressed antimicrobial peptide 2; Has an antimicrobial activity	0.755
LEAP2	ATRN	ENSP00000296877	ENSP00000262919	Liver-expressed antimicrobial peptide 2; Has an antimicrobial activity	Attractin; Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti (By similarity). Has a critical role in normal myelination in the central nervous system (By similarity); C-type lectin domain containing	0.438
LEAP2	CLDN12	ENSP00000296877	ENSP00000287916	Liver-expressed antimicrobial peptide 2; Has an antimicrobial activity	Claudin-12; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins	0.471
LEAP2	CTXN1	ENSP00000296877	ENSP00000313226	Liver-expressed antimicrobial peptide 2; Has an antimicrobial activity	Cortexin-1; May mediate extracellular or intracellular signaling of cortical neurons during forebrain development	0.429
LEAP2	FOLR2	ENSP00000296877	ENSP00000298223	Liver-expressed antimicrobial peptide 2; Has an antimicrobial activity	Folate receptor beta; Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release	0.535
LEAP2	HAMP	ENSP00000296877	ENSP00000471894	Liver-expressed antimicrobial peptide 2; Has an antimicrobial activity	Hepcidin; Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma- absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes; Belongs to the hepcidin family	0.755
LEAP2	PHKA1	ENSP00000296877	ENSP00000362643	Liver-expressed antimicrobial peptide 2; Has an antimicrobial activity	Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin	0.407
LEAP2	PHKA2	ENSP00000296877	ENSP00000369274	Liver-expressed antimicrobial peptide 2; Has an antimicrobial activity	Phosphorylase b kinase regulatory subunit alpha, liver isoform; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin	0.461
LEAP2	SALL3	ENSP00000296877	ENSP00000441823	Liver-expressed antimicrobial peptide 2; Has an antimicrobial activity	Sal-like protein 3; Probable transcription factor; Zinc fingers C2H2-type	0.428
LEAP2	VGF	ENSP00000296877	ENSP00000249330	Liver-expressed antimicrobial peptide 2; Has an antimicrobial activity	Neurosecretory protein VGF; May be involved in the regulation of cell-cell interactions or in synatogenesis during the maturation of the nervous system; Granins	0.582
LEAP2	VSTM2L	ENSP00000296877	ENSP00000362560	Liver-expressed antimicrobial peptide 2; Has an antimicrobial activity	V-set and transmembrane domain-containing protein 2-like protein; V-set and transmembrane domain containing 2 like	0.434
PHKA1	LEAP2	ENSP00000362643	ENSP00000296877	Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin	Liver-expressed antimicrobial peptide 2; Has an antimicrobial activity	0.407
PHKA1	PHKA2	ENSP00000362643	ENSP00000369274	Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin	Phosphorylase b kinase regulatory subunit alpha, liver isoform; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin	0.806
PHKA2	LEAP2	ENSP00000369274	ENSP00000296877	Phosphorylase b kinase regulatory subunit alpha, liver isoform; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin	Liver-expressed antimicrobial peptide 2; Has an antimicrobial activity	0.461
PHKA2	PHKA1	ENSP00000369274	ENSP00000362643	Phosphorylase b kinase regulatory subunit alpha, liver isoform; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin	Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin	0.806

page 1 of 2

Network

Cooccurrence

Databases

Coexpression

Textmining

Neighborhood

Experiments

Fusion

© STRING Consortium 2020

Credits

Access

Info

About