| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APOBR | FOXQ1 | ENSP00000457539 | ENSP00000296839 | Apolipoprotein B receptor; Macrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG)-rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic very low density lipoprotein (HTG-VLDL). Binds and internalizes TRL when out of the context of the macrophage. May provide essential lipids to reticuloendothelial cells. Could also be involved in foam cell formation with elevated TRL and remnant lipoprotein (RLP). Mediates the rapid high-affinity uptake of chylomicrons (CM), HTG- VLDL, and trypsinized (tryp) VLDL devoid of APOE in vitro in mac [...] | Forkhead box protein Q1; Plays a role in hair follicle differentiation; Forkhead boxes | 0.560 |
| CDH1 | FOXQ1 | ENSP00000261769 | ENSP00000296839 | Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 | Forkhead box protein Q1; Plays a role in hair follicle differentiation; Forkhead boxes | 0.619 |
| CDH1 | TCF15 | ENSP00000261769 | ENSP00000246080 | Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 | Transcription factor 15; May function as an early transcriptional regulator, involved in the patterning of the mesoderm and in lineage determination of cell types derived from the mesoderm; Basic helix-loop-helix proteins | 0.466 |
| CDH1 | TWIST1 | ENSP00000261769 | ENSP00000242261 | Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 | Twist-related protein 1; Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN w [...] | 0.923 |
| FOXQ1 | APOBR | ENSP00000296839 | ENSP00000457539 | Forkhead box protein Q1; Plays a role in hair follicle differentiation; Forkhead boxes | Apolipoprotein B receptor; Macrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG)-rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic very low density lipoprotein (HTG-VLDL). Binds and internalizes TRL when out of the context of the macrophage. May provide essential lipids to reticuloendothelial cells. Could also be involved in foam cell formation with elevated TRL and remnant lipoprotein (RLP). Mediates the rapid high-affinity uptake of chylomicrons (CM), HTG- VLDL, and trypsinized (tryp) VLDL devoid of APOE in vitro in mac [...] | 0.560 |
| FOXQ1 | CDH1 | ENSP00000296839 | ENSP00000261769 | Forkhead box protein Q1; Plays a role in hair follicle differentiation; Forkhead boxes | Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 | 0.619 |
| FOXQ1 | GMDS | ENSP00000296839 | ENSP00000370194 | Forkhead box protein Q1; Plays a role in hair follicle differentiation; Forkhead boxes | GDP-mannose 4,6 dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily | 0.632 |
| FOXQ1 | HOXC13 | ENSP00000296839 | ENSP00000243056 | Forkhead box protein Q1; Plays a role in hair follicle differentiation; Forkhead boxes | Homeobox protein Hox-C13; Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes (By similarity); Belongs to the Abd-B homeobox family | 0.629 |
| FOXQ1 | MESP1 | ENSP00000296839 | ENSP00000300057 | Forkhead box protein Q1; Plays a role in hair follicle differentiation; Forkhead boxes | Mesoderm posterior protein 1; Transcription factor. Plays a role in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. Defines the rostrocaudal patterning of the somites by participating in distinct Notch pathways (By similarity); Basic helix-loop-helix proteins | 0.568 |
| FOXQ1 | NACC1 | ENSP00000296839 | ENSP00000292431 | Forkhead box protein Q1; Plays a role in hair follicle differentiation; Forkhead boxes | Nucleus accumbens-associated protein 1; Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines; BEN domain containing | 0.690 |
| FOXQ1 | TCF15 | ENSP00000296839 | ENSP00000246080 | Forkhead box protein Q1; Plays a role in hair follicle differentiation; Forkhead boxes | Transcription factor 15; May function as an early transcriptional regulator, involved in the patterning of the mesoderm and in lineage determination of cell types derived from the mesoderm; Basic helix-loop-helix proteins | 0.559 |
| FOXQ1 | TPPP | ENSP00000296839 | ENSP00000353785 | Forkhead box protein Q1; Plays a role in hair follicle differentiation; Forkhead boxes | Tubulin polymerization-promoting protein; May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a role in mitotic spindle assembly and nuclear envelope breakdown; Belongs to the TPPP family | 0.645 |
| FOXQ1 | TWIST1 | ENSP00000296839 | ENSP00000242261 | Forkhead box protein Q1; Plays a role in hair follicle differentiation; Forkhead boxes | Twist-related protein 1; Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN w [...] | 0.562 |
| FOXQ1 | ZFAND3 | ENSP00000296839 | ENSP00000287218 | Forkhead box protein Q1; Plays a role in hair follicle differentiation; Forkhead boxes | Zinc finger AN1-type containing 3 | 0.662 |
| GMDS | FOXQ1 | ENSP00000370194 | ENSP00000296839 | GDP-mannose 4,6 dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily | Forkhead box protein Q1; Plays a role in hair follicle differentiation; Forkhead boxes | 0.632 |
| GMDS | ZFAND3 | ENSP00000370194 | ENSP00000287218 | GDP-mannose 4,6 dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily | Zinc finger AN1-type containing 3 | 0.592 |
| HOXC13 | FOXQ1 | ENSP00000243056 | ENSP00000296839 | Homeobox protein Hox-C13; Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes (By similarity); Belongs to the Abd-B homeobox family | Forkhead box protein Q1; Plays a role in hair follicle differentiation; Forkhead boxes | 0.629 |
| MESP1 | FOXQ1 | ENSP00000300057 | ENSP00000296839 | Mesoderm posterior protein 1; Transcription factor. Plays a role in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. Defines the rostrocaudal patterning of the somites by participating in distinct Notch pathways (By similarity); Basic helix-loop-helix proteins | Forkhead box protein Q1; Plays a role in hair follicle differentiation; Forkhead boxes | 0.568 |
| NACC1 | FOXQ1 | ENSP00000292431 | ENSP00000296839 | Nucleus accumbens-associated protein 1; Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines; BEN domain containing | Forkhead box protein Q1; Plays a role in hair follicle differentiation; Forkhead boxes | 0.690 |
| TCF15 | CDH1 | ENSP00000246080 | ENSP00000261769 | Transcription factor 15; May function as an early transcriptional regulator, involved in the patterning of the mesoderm and in lineage determination of cell types derived from the mesoderm; Basic helix-loop-helix proteins | Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 | 0.466 |
