node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADAM8 | AFAP1L1 | ENSP00000453302 | ENSP00000296721 | Disintegrin and metalloproteinase domain-containing protein 8; Possible involvement in extravasation of leukocytes; ADAM metallopeptidase domain containing | Actin filament-associated protein 1-like 1; May be involved in podosome and invadosome formation; Pleckstrin homology domain containing | 0.540 |
ADAM8 | ARHGEF5 | ENSP00000453302 | ENSP00000056217 | Disintegrin and metalloproteinase domain-containing protein 8; Possible involvement in extravasation of leukocytes; ADAM metallopeptidase domain containing | Rho guanine nucleotide exchange factor 5; Guanine nucleotide exchange factor which activates Rho GTPases. Strongly activates RHOA. Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization. Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia. Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration [...] | 0.540 |
ADAM8 | CTTN | ENSP00000453302 | ENSP00000365745 | Disintegrin and metalloproteinase domain-containing protein 8; Possible involvement in extravasation of leukocytes; ADAM metallopeptidase domain containing | Src substrate cortactin; Cortactin | 0.551 |
ADAM8 | FSCN1 | ENSP00000453302 | ENSP00000371798 | Disintegrin and metalloproteinase domain-containing protein 8; Possible involvement in extravasation of leukocytes; ADAM metallopeptidase domain containing | Fascin; Organizes filamentous actin into bundles with a minimum of 4.1-1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration; Fascins | 0.720 |
ADAM8 | GSN | ENSP00000453302 | ENSP00000362924 | Disintegrin and metalloproteinase domain-containing protein 8; Possible involvement in extravasation of leukocytes; ADAM metallopeptidase domain containing | Gelsolin; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis; Gelsolin/villins | 0.740 |
ADAM8 | PALLD | ENSP00000453302 | ENSP00000425556 | Disintegrin and metalloproteinase domain-containing protein 8; Possible involvement in extravasation of leukocytes; ADAM metallopeptidase domain containing | Palladin; Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have [...] | 0.540 |
ADAM8 | SH3PXD2A | ENSP00000453302 | ENSP00000348215 | Disintegrin and metalloproteinase domain-containing protein 8; Possible involvement in extravasation of leukocytes; ADAM metallopeptidase domain containing | SH3 and PX domain-containing protein 2A; Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide | 0.729 |
ADAM8 | SH3PXD2B | ENSP00000453302 | ENSP00000309714 | Disintegrin and metalloproteinase domain-containing protein 8; Possible involvement in extravasation of leukocytes; ADAM metallopeptidase domain containing | SH3 and PX domain-containing protein 2B; Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation (By similarity) | 0.725 |
ADAM8 | TJP1 | ENSP00000453302 | ENSP00000281537 | Disintegrin and metalloproteinase domain-containing protein 8; Possible involvement in extravasation of leukocytes; ADAM metallopeptidase domain containing | Tight junction protein ZO-1; The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells; Belongs to the MAGUK family | 0.541 |
AFAP1L1 | ADAM8 | ENSP00000296721 | ENSP00000453302 | Actin filament-associated protein 1-like 1; May be involved in podosome and invadosome formation; Pleckstrin homology domain containing | Disintegrin and metalloproteinase domain-containing protein 8; Possible involvement in extravasation of leukocytes; ADAM metallopeptidase domain containing | 0.540 |
AFAP1L1 | ARHGEF5 | ENSP00000296721 | ENSP00000056217 | Actin filament-associated protein 1-like 1; May be involved in podosome and invadosome formation; Pleckstrin homology domain containing | Rho guanine nucleotide exchange factor 5; Guanine nucleotide exchange factor which activates Rho GTPases. Strongly activates RHOA. Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization. Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia. Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration [...] | 0.549 |
AFAP1L1 | CTTN | ENSP00000296721 | ENSP00000365745 | Actin filament-associated protein 1-like 1; May be involved in podosome and invadosome formation; Pleckstrin homology domain containing | Src substrate cortactin; Cortactin | 0.725 |
AFAP1L1 | FSCN1 | ENSP00000296721 | ENSP00000371798 | Actin filament-associated protein 1-like 1; May be involved in podosome and invadosome formation; Pleckstrin homology domain containing | Fascin; Organizes filamentous actin into bundles with a minimum of 4.1-1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration; Fascins | 0.570 |
AFAP1L1 | GSN | ENSP00000296721 | ENSP00000362924 | Actin filament-associated protein 1-like 1; May be involved in podosome and invadosome formation; Pleckstrin homology domain containing | Gelsolin; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis; Gelsolin/villins | 0.587 |
AFAP1L1 | PALLD | ENSP00000296721 | ENSP00000425556 | Actin filament-associated protein 1-like 1; May be involved in podosome and invadosome formation; Pleckstrin homology domain containing | Palladin; Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have [...] | 0.550 |
AFAP1L1 | SH3PXD2A | ENSP00000296721 | ENSP00000348215 | Actin filament-associated protein 1-like 1; May be involved in podosome and invadosome formation; Pleckstrin homology domain containing | SH3 and PX domain-containing protein 2A; Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide | 0.626 |
AFAP1L1 | SH3PXD2B | ENSP00000296721 | ENSP00000309714 | Actin filament-associated protein 1-like 1; May be involved in podosome and invadosome formation; Pleckstrin homology domain containing | SH3 and PX domain-containing protein 2B; Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation (By similarity) | 0.551 |
AFAP1L1 | TJP1 | ENSP00000296721 | ENSP00000281537 | Actin filament-associated protein 1-like 1; May be involved in podosome and invadosome formation; Pleckstrin homology domain containing | Tight junction protein ZO-1; The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells; Belongs to the MAGUK family | 0.564 |
AFAP1L1 | TPCN1 | ENSP00000296721 | ENSP00000448083 | Actin filament-associated protein 1-like 1; May be involved in podosome and invadosome formation; Pleckstrin homology domain containing | Two pore calcium channel protein 1; Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal and endosomal membrane; Two pore segment channels | 0.590 |
ARHGEF5 | ADAM8 | ENSP00000056217 | ENSP00000453302 | Rho guanine nucleotide exchange factor 5; Guanine nucleotide exchange factor which activates Rho GTPases. Strongly activates RHOA. Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1 (By similarity). Involved in regulation of cell shape and actin cytoskeletal organization. Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia. Required for SRC-induced podosome formation (By similarity). Involved in positive regulation of immature dendritic cell migration [...] | Disintegrin and metalloproteinase domain-containing protein 8; Possible involvement in extravasation of leukocytes; ADAM metallopeptidase domain containing | 0.540 |