node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EDN2 | EDN3 | ENSP00000361668 | ENSP00000337128 | Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Endogenous ligands | Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides; Endogenous ligands | 0.921 |
EDN2 | PRMT9 | ENSP00000361668 | ENSP00000314396 | Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Endogenous ligands | Protein arginine N-methyltransferase 9; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA). Specifically mediates the symmetrical dimethylation of SF3B2. Involved in the regulation of alternative splicing of pre-mRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N- methyltransferase family | 0.548 |
EDN2 | TMEM184C | ENSP00000361668 | ENSP00000296582 | Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Endogenous ligands | Transmembrane protein 184C; Possible tumor suppressor which may play a role in cell growth; Belongs to the TMEM184 family | 0.526 |
EDN3 | EDN2 | ENSP00000337128 | ENSP00000361668 | Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides; Endogenous ligands | Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Endogenous ligands | 0.921 |
EDN3 | PRMT9 | ENSP00000337128 | ENSP00000314396 | Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides; Endogenous ligands | Protein arginine N-methyltransferase 9; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA). Specifically mediates the symmetrical dimethylation of SF3B2. Involved in the regulation of alternative splicing of pre-mRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N- methyltransferase family | 0.428 |
EDN3 | TMEM184C | ENSP00000337128 | ENSP00000296582 | Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides; Endogenous ligands | Transmembrane protein 184C; Possible tumor suppressor which may play a role in cell growth; Belongs to the TMEM184 family | 0.477 |
NUPL2 | PPIL1 | ENSP00000258742 | ENSP00000362803 | Nucleoporin-like protein 2; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. In case of infection by HIV-1, it may participate in the docking of viral Vpr at the nuclear envelope | Peptidyl-prolyl cis-trans isomerase-like 1; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing; Cyclophilin peptidylprolyl isomerases | 0.496 |
NUPL2 | TMEM184C | ENSP00000258742 | ENSP00000296582 | Nucleoporin-like protein 2; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. In case of infection by HIV-1, it may participate in the docking of viral Vpr at the nuclear envelope | Transmembrane protein 184C; Possible tumor suppressor which may play a role in cell growth; Belongs to the TMEM184 family | 0.518 |
PPIL1 | NUPL2 | ENSP00000362803 | ENSP00000258742 | Peptidyl-prolyl cis-trans isomerase-like 1; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing; Cyclophilin peptidylprolyl isomerases | Nucleoporin-like protein 2; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. In case of infection by HIV-1, it may participate in the docking of viral Vpr at the nuclear envelope | 0.496 |
PPIL1 | TMEM184C | ENSP00000362803 | ENSP00000296582 | Peptidyl-prolyl cis-trans isomerase-like 1; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing; Cyclophilin peptidylprolyl isomerases | Transmembrane protein 184C; Possible tumor suppressor which may play a role in cell growth; Belongs to the TMEM184 family | 0.500 |
PRMT9 | EDN2 | ENSP00000314396 | ENSP00000361668 | Protein arginine N-methyltransferase 9; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA). Specifically mediates the symmetrical dimethylation of SF3B2. Involved in the regulation of alternative splicing of pre-mRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N- methyltransferase family | Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Endogenous ligands | 0.548 |
PRMT9 | EDN3 | ENSP00000314396 | ENSP00000337128 | Protein arginine N-methyltransferase 9; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA). Specifically mediates the symmetrical dimethylation of SF3B2. Involved in the regulation of alternative splicing of pre-mRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N- methyltransferase family | Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides; Endogenous ligands | 0.428 |
PRMT9 | TMEM184C | ENSP00000314396 | ENSP00000296582 | Protein arginine N-methyltransferase 9; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA). Specifically mediates the symmetrical dimethylation of SF3B2. Involved in the regulation of alternative splicing of pre-mRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N- methyltransferase family | Transmembrane protein 184C; Possible tumor suppressor which may play a role in cell growth; Belongs to the TMEM184 family | 0.809 |
TMEM147 | TMEM184C | ENSP00000222284 | ENSP00000296582 | Transmembrane protein 147 | Transmembrane protein 184C; Possible tumor suppressor which may play a role in cell growth; Belongs to the TMEM184 family | 0.680 |
TMEM147 | TMEM196 | ENSP00000222284 | ENSP00000384234 | Transmembrane protein 147 | Transmembrane protein 196 | 0.553 |
TMEM147 | TMEM207 | ENSP00000222284 | ENSP00000346981 | Transmembrane protein 147 | Transmembrane protein 207 | 0.598 |
TMEM147 | TMEM214 | ENSP00000222284 | ENSP00000238788 | Transmembrane protein 147 | Transmembrane protein 214; Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress; Belongs to the TMEM214 family | 0.576 |
TMEM147 | VEZT | ENSP00000222284 | ENSP00000410083 | Transmembrane protein 147 | Vezatin; Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. In case of Listeria infection, promotes bacterial internalization by participating in myosin VIIa recruitment to the entry site; Belongs to the vezatin family | 0.485 |
TMEM184C | EDN2 | ENSP00000296582 | ENSP00000361668 | Transmembrane protein 184C; Possible tumor suppressor which may play a role in cell growth; Belongs to the TMEM184 family | Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Endogenous ligands | 0.526 |
TMEM184C | EDN3 | ENSP00000296582 | ENSP00000337128 | Transmembrane protein 184C; Possible tumor suppressor which may play a role in cell growth; Belongs to the TMEM184 family | Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides; Endogenous ligands | 0.477 |