| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATP2B2 | ENSG00000253117 | ENSP00000353414 | ENSP00000262283 | Plasma membrane calcium-transporting ATPase 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell; ATPases Ca2+ transporting | Otoconin-90; It is unlikely that this protein has phospholipase A2 activity | 0.742 |
| ATP2B2 | ENSG00000253117 | ENSP00000353414 | ENSP00000254627 | Plasma membrane calcium-transporting ATPase 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell; ATPases Ca2+ transporting | Otoconin 90; It is unlikely that this protein has phospholipase A2 activity | 0.742 |
| ATP2B2 | OTOP1 | ENSP00000353414 | ENSP00000296358 | Plasma membrane calcium-transporting ATPase 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell; ATPases Ca2+ transporting | Otopetrin-1; Required for normal formation of otoconia in the inner ear. Inhibits P2Y purinoceptors. Modulates calcium homeostasis and influx of calcium in response to extracellular ATP (By similarity) | 0.720 |
| ATP2B4 | ENSG00000253117 | ENSP00000350310 | ENSP00000262283 | Plasma membrane calcium-transporting ATPase 4; Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell. By regulating sperm cell calcium homeostasis, may play a role in sperm motility (By similarity); Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily | Otoconin-90; It is unlikely that this protein has phospholipase A2 activity | 0.649 |
| ATP2B4 | ENSG00000253117 | ENSP00000350310 | ENSP00000254627 | Plasma membrane calcium-transporting ATPase 4; Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell. By regulating sperm cell calcium homeostasis, may play a role in sperm motility (By similarity); Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily | Otoconin 90; It is unlikely that this protein has phospholipase A2 activity | 0.649 |
| ATP2B4 | OTOP1 | ENSP00000350310 | ENSP00000296358 | Plasma membrane calcium-transporting ATPase 4; Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell. By regulating sperm cell calcium homeostasis, may play a role in sperm motility (By similarity); Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily | Otopetrin-1; Required for normal formation of otoconia in the inner ear. Inhibits P2Y purinoceptors. Modulates calcium homeostasis and influx of calcium in response to extracellular ATP (By similarity) | 0.647 |
| COX7A1 | OTOP1 | ENSP00000292907 | ENSP00000296358 | Cytochrome c oxidase subunit 7A1, mitochondrial; This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport | Otopetrin-1; Required for normal formation of otoconia in the inner ear. Inhibits P2Y purinoceptors. Modulates calcium homeostasis and influx of calcium in response to extracellular ATP (By similarity) | 0.587 |
| ENSG00000253117 | ATP2B2 | ENSP00000254627 | ENSP00000353414 | Otoconin 90; It is unlikely that this protein has phospholipase A2 activity | Plasma membrane calcium-transporting ATPase 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell; ATPases Ca2+ transporting | 0.742 |
| ENSG00000253117 | ATP2B2 | ENSP00000262283 | ENSP00000353414 | Otoconin-90; It is unlikely that this protein has phospholipase A2 activity | Plasma membrane calcium-transporting ATPase 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell; ATPases Ca2+ transporting | 0.742 |
| ENSG00000253117 | ATP2B4 | ENSP00000254627 | ENSP00000350310 | Otoconin 90; It is unlikely that this protein has phospholipase A2 activity | Plasma membrane calcium-transporting ATPase 4; Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell. By regulating sperm cell calcium homeostasis, may play a role in sperm motility (By similarity); Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily | 0.649 |
| ENSG00000253117 | ATP2B4 | ENSP00000262283 | ENSP00000350310 | Otoconin-90; It is unlikely that this protein has phospholipase A2 activity | Plasma membrane calcium-transporting ATPase 4; Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell. By regulating sperm cell calcium homeostasis, may play a role in sperm motility (By similarity); Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily | 0.649 |
| ENSG00000253117 | NOX3 | ENSP00000262283 | ENSP00000159060 | Otoconin-90; It is unlikely that this protein has phospholipase A2 activity | NADPH oxidase 3; NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity | 0.623 |
| ENSG00000253117 | NOX3 | ENSP00000254627 | ENSP00000159060 | Otoconin 90; It is unlikely that this protein has phospholipase A2 activity | NADPH oxidase 3; NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity | 0.623 |
| ENSG00000253117 | OTOG | ENSP00000262283 | ENSP00000382323 | Otoconin-90; It is unlikely that this protein has phospholipase A2 activity | Otogelin; Glycoprotein specific to acellular membranes of the inner ear. May be required for the anchoring of the otoconial membranes and cupulae to the underlying neuroepithelia in the vestibule. May be involved in the organization and/or stabilization of the fibrillar network that compose the tectorial membrane in the cochlea. May play a role in mechanotransduction processes (By similarity) | 0.557 |
| ENSG00000253117 | OTOG | ENSP00000254627 | ENSP00000382323 | Otoconin 90; It is unlikely that this protein has phospholipase A2 activity | Otogelin; Glycoprotein specific to acellular membranes of the inner ear. May be required for the anchoring of the otoconial membranes and cupulae to the underlying neuroepithelia in the vestibule. May be involved in the organization and/or stabilization of the fibrillar network that compose the tectorial membrane in the cochlea. May play a role in mechanotransduction processes (By similarity) | 0.557 |
| ENSG00000253117 | OTOP1 | ENSP00000262283 | ENSP00000296358 | Otoconin-90; It is unlikely that this protein has phospholipase A2 activity | Otopetrin-1; Required for normal formation of otoconia in the inner ear. Inhibits P2Y purinoceptors. Modulates calcium homeostasis and influx of calcium in response to extracellular ATP (By similarity) | 0.822 |
| ENSG00000253117 | OTOP1 | ENSP00000254627 | ENSP00000296358 | Otoconin 90; It is unlikely that this protein has phospholipase A2 activity | Otopetrin-1; Required for normal formation of otoconia in the inner ear. Inhibits P2Y purinoceptors. Modulates calcium homeostasis and influx of calcium in response to extracellular ATP (By similarity) | 0.822 |
| NOX3 | ENSG00000253117 | ENSP00000159060 | ENSP00000254627 | NADPH oxidase 3; NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity | Otoconin 90; It is unlikely that this protein has phospholipase A2 activity | 0.623 |
| NOX3 | ENSG00000253117 | ENSP00000159060 | ENSP00000262283 | NADPH oxidase 3; NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity | Otoconin-90; It is unlikely that this protein has phospholipase A2 activity | 0.623 |
| NOX3 | NOXA1 | ENSP00000159060 | ENSP00000342848 | NADPH oxidase 3; NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity | NADPH oxidase activator 1; Functions as an activator of NOX1, a superoxide- producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3; Belongs to the NCF2/NOXA1 family | 0.980 |
