node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGT | CMA1 | ENSP00000355627 | ENSP00000250378 | Angiotensinogen; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis; Endogenous ligands | Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion | 0.983 |
AGT | CPA3 | ENSP00000355627 | ENSP00000296046 | Angiotensinogen; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis; Endogenous ligands | M14 carboxypeptidases | 0.908 |
AGT | CTSG | ENSP00000355627 | ENSP00000216336 | Angiotensinogen; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis; Endogenous ligands | Cathepsin G; Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe- CH2Cl and phenylmethylsulfonyl fluoride; Belongs to the peptidase S1 family | 0.965 |
CMA1 | AGT | ENSP00000250378 | ENSP00000355627 | Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion | Angiotensinogen; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis; Endogenous ligands | 0.983 |
CMA1 | CPA3 | ENSP00000250378 | ENSP00000296046 | Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion | M14 carboxypeptidases | 0.843 |
CMA1 | FCER1A | ENSP00000250378 | ENSP00000357097 | Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion | High affinity immunoglobulin epsilon receptor subunit alpha; Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines; Immunoglobulin like domain containing | 0.463 |
CPA1 | CPA2 | ENSP00000011292 | ENSP00000222481 | Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C- terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro; Belongs to the peptidase M14 family | M14 carboxypeptidases | 0.867 |
CPA1 | CPA3 | ENSP00000011292 | ENSP00000296046 | Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C- terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro; Belongs to the peptidase M14 family | M14 carboxypeptidases | 0.828 |
CPA2 | CPA1 | ENSP00000222481 | ENSP00000011292 | M14 carboxypeptidases | Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C- terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro; Belongs to the peptidase M14 family | 0.867 |
CPA2 | CPA3 | ENSP00000222481 | ENSP00000296046 | M14 carboxypeptidases | M14 carboxypeptidases | 0.820 |
CPA3 | AGT | ENSP00000296046 | ENSP00000355627 | M14 carboxypeptidases | Angiotensinogen; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis; Endogenous ligands | 0.908 |
CPA3 | CMA1 | ENSP00000296046 | ENSP00000250378 | M14 carboxypeptidases | Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion | 0.843 |
CPA3 | CPA1 | ENSP00000296046 | ENSP00000011292 | M14 carboxypeptidases | Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C- terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro; Belongs to the peptidase M14 family | 0.828 |
CPA3 | CPA2 | ENSP00000296046 | ENSP00000222481 | M14 carboxypeptidases | M14 carboxypeptidases | 0.820 |
CPA3 | CTSG | ENSP00000296046 | ENSP00000216336 | M14 carboxypeptidases | Cathepsin G; Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe- CH2Cl and phenylmethylsulfonyl fluoride; Belongs to the peptidase S1 family | 0.721 |
CPA3 | FCER1A | ENSP00000296046 | ENSP00000357097 | M14 carboxypeptidases | High affinity immunoglobulin epsilon receptor subunit alpha; Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines; Immunoglobulin like domain containing | 0.784 |
CPA3 | HDC | ENSP00000296046 | ENSP00000267845 | M14 carboxypeptidases | Histidine decarboxylase; Catalyzes the biosynthesis of histamine from histidine; Belongs to the group II decarboxylase family | 0.797 |
CPA3 | NDST2 | ENSP00000296046 | ENSP00000310657 | M14 carboxypeptidases | Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Required for the exosomal release of SDCBP, CD63 and syndecan; Sulfotransferases, membrane bound | 0.901 |
CPA3 | TPSAB1 | ENSP00000296046 | ENSP00000343577 | M14 carboxypeptidases | Tryptase alpha/beta-1; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. Isoform 2 cleaves large substrates, such as fibronectin, more efficiently than isoform 1, but seems less efficient toward small substrates; Belongs to the peptidase S1 family. Tryptase subfamily | 0.888 |
CPA3 | TPSB2 | ENSP00000296046 | ENSP00000482743 | M14 carboxypeptidases | Tryptase beta 2; Belongs to the peptidase S1 family | 0.726 |