EFHB protein (human) - STRING database

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EFHB

EF-hand domain family member B; Cilia and flagella associated (833 aa)

Predicted Functional Partners:

CEACAM21

0.726

CAPSL

0.725

SUMO4

0.485

TDRD6

0.470

PAX4

0.414

TSSK2

0.412

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CAPSL	CEACAM21	ENSP00000380524	ENSP00000385739	Calcyphosin-like protein; EF-hand domain containing	Carcinoembryonic antigen related cell adhesion molecule family; Belongs to the immunoglobulin superfamily. CEA family	0.670
CAPSL	EFHB	ENSP00000380524	ENSP00000295824	Calcyphosin-like protein; EF-hand domain containing	EF-hand domain family member B; Cilia and flagella associated	0.725
CAPSL	SUMO4	ENSP00000380524	ENSP00000318635	Calcyphosin-like protein; EF-hand domain containing	Small ubiquitin-related modifier 4; Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior activation by t [...]	0.425
CEACAM21	CAPSL	ENSP00000385739	ENSP00000380524	Carcinoembryonic antigen related cell adhesion molecule family; Belongs to the immunoglobulin superfamily. CEA family	Calcyphosin-like protein; EF-hand domain containing	0.670
CEACAM21	EFHB	ENSP00000385739	ENSP00000295824	Carcinoembryonic antigen related cell adhesion molecule family; Belongs to the immunoglobulin superfamily. CEA family	EF-hand domain family member B; Cilia and flagella associated	0.726
CEACAM21	SUMO4	ENSP00000385739	ENSP00000318635	Carcinoembryonic antigen related cell adhesion molecule family; Belongs to the immunoglobulin superfamily. CEA family	Small ubiquitin-related modifier 4; Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior activation by t [...]	0.420
EFHB	CAPSL	ENSP00000295824	ENSP00000380524	EF-hand domain family member B; Cilia and flagella associated	Calcyphosin-like protein; EF-hand domain containing	0.725
EFHB	CEACAM21	ENSP00000295824	ENSP00000385739	EF-hand domain family member B; Cilia and flagella associated	Carcinoembryonic antigen related cell adhesion molecule family; Belongs to the immunoglobulin superfamily. CEA family	0.726
EFHB	PAX4	ENSP00000295824	ENSP00000339906	EF-hand domain family member B; Cilia and flagella associated	Paired box protein Pax-4; Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that binds to a common element in the glucagon, insulin and somatostatin promoters. Competes with PAX6 for this same promoter binding site. Isoform 2 appears to be a dominant negative form antagonizing PAX4 transcriptional activity; PRD class homeoboxes and pseudogenes	0.414
EFHB	SUMO4	ENSP00000295824	ENSP00000318635	EF-hand domain family member B; Cilia and flagella associated	Small ubiquitin-related modifier 4; Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior activation by t [...]	0.485
EFHB	TDRD6	ENSP00000295824	ENSP00000346065	EF-hand domain family member B; Cilia and flagella associated	Tudor domain-containing protein 6; Involved in spermiogenesis, chromatoid body formation and for proper precursor and mature miRNA expression; Tudor domain containing	0.470
EFHB	TSSK2	ENSP00000295824	ENSP00000382544	EF-hand domain family member B; Cilia and flagella associated	Testis-specific serine/threonine-protein kinase 2; Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates TSKS at ’Ser-288’ and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body	0.412
PAX4	EFHB	ENSP00000339906	ENSP00000295824	Paired box protein Pax-4; Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that binds to a common element in the glucagon, insulin and somatostatin promoters. Competes with PAX6 for this same promoter binding site. Isoform 2 appears to be a dominant negative form antagonizing PAX4 transcriptional activity; PRD class homeoboxes and pseudogenes	EF-hand domain family member B; Cilia and flagella associated	0.414
SUMO4	CAPSL	ENSP00000318635	ENSP00000380524	Small ubiquitin-related modifier 4; Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior activation by t [...]	Calcyphosin-like protein; EF-hand domain containing	0.425
SUMO4	CEACAM21	ENSP00000318635	ENSP00000385739	Small ubiquitin-related modifier 4; Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior activation by t [...]	Carcinoembryonic antigen related cell adhesion molecule family; Belongs to the immunoglobulin superfamily. CEA family	0.420
SUMO4	EFHB	ENSP00000318635	ENSP00000295824	Small ubiquitin-related modifier 4; Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior activation by t [...]	EF-hand domain family member B; Cilia and flagella associated	0.485
TDRD6	EFHB	ENSP00000346065	ENSP00000295824	Tudor domain-containing protein 6; Involved in spermiogenesis, chromatoid body formation and for proper precursor and mature miRNA expression; Tudor domain containing	EF-hand domain family member B; Cilia and flagella associated	0.470
TSSK2	EFHB	ENSP00000382544	ENSP00000295824	Testis-specific serine/threonine-protein kinase 2; Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates TSKS at ’Ser-288’ and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body	EF-hand domain family member B; Cilia and flagella associated	0.412

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