node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCDC108 | CRYBA2 | ENSP00000340776 | ENSP00000295728 | Cilia- and flagella-associated protein 65; May play a role in sperm motility; Belongs to the CFAP65 family | Beta-crystallin A2; Crystallins are the dominant structural components of the vertebrate eye lens | 0.735 |
CRYA1 | CRYAB | ENSP00000482816 | ENSP00000433560 | Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins | Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins | 0.913 |
CRYA1 | CRYBA2 | ENSP00000482816 | ENSP00000295728 | Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins | Beta-crystallin A2; Crystallins are the dominant structural components of the vertebrate eye lens | 0.788 |
CRYA1 | LIM2 | ENSP00000482816 | ENSP00000221973 | Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins | Lens intrinsic membrane protein 2 | 0.815 |
CRYAB | CRYA1 | ENSP00000433560 | ENSP00000482816 | Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins | Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins | 0.913 |
CRYAB | CRYBA2 | ENSP00000433560 | ENSP00000295728 | Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins | Beta-crystallin A2; Crystallins are the dominant structural components of the vertebrate eye lens | 0.662 |
CRYAB | HSPB4 | ENSP00000433560 | ENSP00000291554 | Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins | Crystallin, alpha A; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins | 0.898 |
CRYAB | LIM2 | ENSP00000433560 | ENSP00000221973 | Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins | Lens intrinsic membrane protein 2 | 0.679 |
CRYBA2 | CCDC108 | ENSP00000295728 | ENSP00000340776 | Beta-crystallin A2; Crystallins are the dominant structural components of the vertebrate eye lens | Cilia- and flagella-associated protein 65; May play a role in sperm motility; Belongs to the CFAP65 family | 0.735 |
CRYBA2 | CRYA1 | ENSP00000295728 | ENSP00000482816 | Beta-crystallin A2; Crystallins are the dominant structural components of the vertebrate eye lens | Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins | 0.788 |
CRYBA2 | CRYAB | ENSP00000295728 | ENSP00000433560 | Beta-crystallin A2; Crystallins are the dominant structural components of the vertebrate eye lens | Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins | 0.662 |
CRYBA2 | FAM132A | ENSP00000295728 | ENSP00000329137 | Beta-crystallin A2; Crystallins are the dominant structural components of the vertebrate eye lens | Adipolin; Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue | 0.502 |
CRYBA2 | GABRG2 | ENSP00000295728 | ENSP00000410732 | Beta-crystallin A2; Crystallins are the dominant structural components of the vertebrate eye lens | Gamma-aminobutyric acid receptor subunit gamma-2; Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand- gated chloride channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG2 sub-subfamily | 0.505 |
CRYBA2 | HSPB4 | ENSP00000295728 | ENSP00000291554 | Beta-crystallin A2; Crystallins are the dominant structural components of the vertebrate eye lens | Crystallin, alpha A; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins | 0.788 |
CRYBA2 | KRBA1 | ENSP00000295728 | ENSP00000317165 | Beta-crystallin A2; Crystallins are the dominant structural components of the vertebrate eye lens | Protein KRBA1; KRAB-A domain containing 1 | 0.556 |
CRYBA2 | LIM2 | ENSP00000295728 | ENSP00000221973 | Beta-crystallin A2; Crystallins are the dominant structural components of the vertebrate eye lens | Lens intrinsic membrane protein 2 | 0.527 |
CRYBA2 | MUC13 | ENSP00000295728 | ENSP00000485028 | Beta-crystallin A2; Crystallins are the dominant structural components of the vertebrate eye lens | Mucin-13; Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling; Mucins | 0.507 |
CRYBA2 | TM4SF4 | ENSP00000295728 | ENSP00000305852 | Beta-crystallin A2; Crystallins are the dominant structural components of the vertebrate eye lens | Transmembrane 4 L6 family member 4; Regulates the adhesive and proliferative status of intestinal epithelial cells. Can mediate density-dependent cell proliferation | 0.511 |
FAM132A | CRYBA2 | ENSP00000329137 | ENSP00000295728 | Adipolin; Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue | Beta-crystallin A2; Crystallins are the dominant structural components of the vertebrate eye lens | 0.502 |
GABRG2 | CRYBA2 | ENSP00000410732 | ENSP00000295728 | Gamma-aminobutyric acid receptor subunit gamma-2; Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand- gated chloride channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG2 sub-subfamily | Beta-crystallin A2; Crystallins are the dominant structural components of the vertebrate eye lens | 0.505 |