• Version:
  • 11.0 [archived version]
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MUC13 MUC13 GABRG2 GABRG2 CCDC108 CCDC108 CRYA1 CRYA1 FAM132A FAM132A CRYBA2 CRYBA2 CRYAB CRYAB LIM2 LIM2 TM4SF4 TM4SF4 HSPB4 HSPB4 KRBA1 KRBA1
"CRYBA2" - Beta-crystallin A2 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
CRYBA2Beta-crystallin A2; Crystallins are the dominant structural components of the vertebrate eye lens (197 aa)    
Predicted Functional Partners:
CRYA1
Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins (173 aa)
     
   
  0.788
HSPB4
Crystallin, alpha A; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins (173 aa)
     
   
  0.788
CCDC108
Cilia- and flagella-associated protein 65; May play a role in sperm motility; Belongs to the CFAP65 family (1925 aa)
           
  0.735
CRYAB
Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins (175 aa)
     
   
  0.662
KRBA1
Protein KRBA1; KRAB-A domain containing 1 (1030 aa)
           
  0.556
LIM2
Lens intrinsic membrane protein 2 (215 aa)
     
   
  0.527
TM4SF4
Transmembrane 4 L6 family member 4; Regulates the adhesive and proliferative status of intestinal epithelial cells. Can mediate density-dependent cell proliferation (202 aa)
     
   
  0.511
MUC13
Mucin-13; Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling; Mucins (512 aa)
     
   
  0.507
GABRG2
Gamma-aminobutyric acid receptor subunit gamma-2; Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand- gated chloride channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG2 sub-subfamily (515 aa)
           
  0.505
FAM132A
Adipolin; Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue (302 aa)
           
  0.502
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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