DCST1 protein (human) - STRING database

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DCST1

E3 ubiquitin-protein ligase DCST1; E3 ubiquitin-protein ligase which mediates ’Lys-48’- linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling; Ring finger proteins (706 aa)

Predicted Functional Partners:

RNF44

0.656

STAT2

0.651

NUP210L

0.632

TMEM63B

0.610

TCTE1

0.604

MARCH4

0.590

ACP5

0.588

LRRC48

0.586

CCIN

0.581

PBXIP1

0.580

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACP5	DCST1	ENSP00000468767	ENSP00000295542	Tartrate-resistant acid phosphatase type 5; Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias; Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family	E3 ubiquitin-protein ligase DCST1; E3 ubiquitin-protein ligase which mediates ’Lys-48’- linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling; Ring finger proteins	0.588
CCIN	DCST1	ENSP00000334996	ENSP00000295542	Calicin; Possible morphogenetic cytoskeletal element in spermiogenic differentiation; BTB domain containing	E3 ubiquitin-protein ligase DCST1; E3 ubiquitin-protein ligase which mediates ’Lys-48’- linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling; Ring finger proteins	0.581
CCIN	MARCH4	ENSP00000334996	ENSP00000273067	Calicin; Possible morphogenetic cytoskeletal element in spermiogenic differentiation; BTB domain containing	E3 ubiquitin-protein ligase MARCH4; E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates; Membrane associated ring-CH-type fingers	0.527
CCIN	RNF44	ENSP00000334996	ENSP00000274811	Calicin; Possible morphogenetic cytoskeletal element in spermiogenic differentiation; BTB domain containing	Ring finger protein 44	0.560
DCST1	ACP5	ENSP00000295542	ENSP00000468767	E3 ubiquitin-protein ligase DCST1; E3 ubiquitin-protein ligase which mediates ’Lys-48’- linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling; Ring finger proteins	Tartrate-resistant acid phosphatase type 5; Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias; Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family	0.588
DCST1	CCIN	ENSP00000295542	ENSP00000334996	E3 ubiquitin-protein ligase DCST1; E3 ubiquitin-protein ligase which mediates ’Lys-48’- linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling; Ring finger proteins	Calicin; Possible morphogenetic cytoskeletal element in spermiogenic differentiation; BTB domain containing	0.581
DCST1	LRRC48	ENSP00000295542	ENSP00000382140	E3 ubiquitin-protein ligase DCST1; E3 ubiquitin-protein ligase which mediates ’Lys-48’- linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling; Ring finger proteins	Dynein regulatory complex subunit 3; Key component of the nexin-dynein regulatory complex (N- DRC), a key regulator of ciliary motility	0.586
DCST1	MARCH4	ENSP00000295542	ENSP00000273067	E3 ubiquitin-protein ligase DCST1; E3 ubiquitin-protein ligase which mediates ’Lys-48’- linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling; Ring finger proteins	E3 ubiquitin-protein ligase MARCH4; E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates; Membrane associated ring-CH-type fingers	0.590
DCST1	NUP210L	ENSP00000295542	ENSP00000357547	E3 ubiquitin-protein ligase DCST1; E3 ubiquitin-protein ligase which mediates ’Lys-48’- linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling; Ring finger proteins	Nuclear pore membrane glycoprotein 210-like; Nucleoporin 210 like; Belongs to the NUP210 family	0.632
DCST1	PBXIP1	ENSP00000295542	ENSP00000357448	E3 ubiquitin-protein ligase DCST1; E3 ubiquitin-protein ligase which mediates ’Lys-48’- linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling; Ring finger proteins	Pre-B-cell leukemia transcription factor-interacting protein 1; Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling	0.580
DCST1	RNF44	ENSP00000295542	ENSP00000274811	E3 ubiquitin-protein ligase DCST1; E3 ubiquitin-protein ligase which mediates ’Lys-48’- linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling; Ring finger proteins	Ring finger protein 44	0.656
DCST1	STAT2	ENSP00000295542	ENSP00000315768	E3 ubiquitin-protein ligase DCST1; E3 ubiquitin-protein ligase which mediates ’Lys-48’- linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling; Ring finger proteins	Signal transducer and activator of transcription 2; Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive [...]	0.651
DCST1	TCTE1	ENSP00000295542	ENSP00000360560	E3 ubiquitin-protein ligase DCST1; E3 ubiquitin-protein ligase which mediates ’Lys-48’- linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling; Ring finger proteins	T-complex-associated-testis-expressed 1; Dynein regulatory complex	0.604
DCST1	TMEM63B	ENSP00000295542	ENSP00000259746	E3 ubiquitin-protein ligase DCST1; E3 ubiquitin-protein ligase which mediates ’Lys-48’- linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling; Ring finger proteins	CSC1-like protein 2; Acts as an osmosensitive calcium-permeable cation channel	0.610
LRRC48	DCST1	ENSP00000382140	ENSP00000295542	Dynein regulatory complex subunit 3; Key component of the nexin-dynein regulatory complex (N- DRC), a key regulator of ciliary motility	E3 ubiquitin-protein ligase DCST1; E3 ubiquitin-protein ligase which mediates ’Lys-48’- linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling; Ring finger proteins	0.586
LRRC48	NUP210L	ENSP00000382140	ENSP00000357547	Dynein regulatory complex subunit 3; Key component of the nexin-dynein regulatory complex (N- DRC), a key regulator of ciliary motility	Nuclear pore membrane glycoprotein 210-like; Nucleoporin 210 like; Belongs to the NUP210 family	0.600
LRRC48	PBXIP1	ENSP00000382140	ENSP00000357448	Dynein regulatory complex subunit 3; Key component of the nexin-dynein regulatory complex (N- DRC), a key regulator of ciliary motility	Pre-B-cell leukemia transcription factor-interacting protein 1; Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling	0.547
LRRC48	TCTE1	ENSP00000382140	ENSP00000360560	Dynein regulatory complex subunit 3; Key component of the nexin-dynein regulatory complex (N- DRC), a key regulator of ciliary motility	T-complex-associated-testis-expressed 1; Dynein regulatory complex	0.565
LRRC48	TMEM63B	ENSP00000382140	ENSP00000259746	Dynein regulatory complex subunit 3; Key component of the nexin-dynein regulatory complex (N- DRC), a key regulator of ciliary motility	CSC1-like protein 2; Acts as an osmosensitive calcium-permeable cation channel	0.533
MARCH4	CCIN	ENSP00000273067	ENSP00000334996	E3 ubiquitin-protein ligase MARCH4; E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates; Membrane associated ring-CH-type fingers	Calicin; Possible morphogenetic cytoskeletal element in spermiogenic differentiation; BTB domain containing	0.527

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