node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALPI | ALPPL2 | ENSP00000295463 | ENSP00000295453 | Alkaline phosphatase, intestinal | Alkaline phosphatase, placental like 2 | 0.968 |
ALPI | CEACAM5 | ENSP00000295463 | ENSP00000221992 | Alkaline phosphatase, intestinal | Carcinoembryonic antigen-related cell adhesion molecule 5; Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins; CD molecules | 0.916 |
ALPI | GCH1 | ENSP00000295463 | ENSP00000419045 | Alkaline phosphatase, intestinal | GTP cyclohydrolase 1; Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown; Belongs to the GTP cyclohydrolase I family | 0.910 |
ALPI | GPLD1 | ENSP00000295463 | ENSP00000230036 | Alkaline phosphatase, intestinal | Phosphatidylinositol-glycan-specific phospholipase D; This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane | 0.909 |
ALPI | LYPD8 | ENSP00000295463 | ENSP00000466070 | Alkaline phosphatase, intestinal | Ly6/PLAUR domain-containing protein 8; Secreted protein specifically required to prevent invasion of Gram-negative bacteria in the inner mucus layer of the colon epithelium, a portion of the large intestine which is free of commensal microbiota. Prevents invasion of flagellated microbiota by binding to the flagellum of bacteria, such as P.mirabilis, thereby inhibiting bacterial motility in the intestinal lumen. Segregation of intestinal bacteria and epithelial cells in the colon is required to preserve intestinal homeostasis; LY6/PLAUR domain containing | 0.907 |
ALPI | NTPCR | ENSP00000295463 | ENSP00000355587 | Alkaline phosphatase, intestinal | Cancer-related nucleoside-triphosphatase; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphates with lower efficiency; Belongs to the THEP1 NTPase family | 0.910 |
ALPI | PDXK | ENSP00000295463 | ENSP00000291565 | Alkaline phosphatase, intestinal | Pyridoxal kinase; Required for synthesis of pyridoxal-5-phosphate from vitamin B6; Belongs to the pyridoxine kinase family | 0.908 |
ALPI | PTS | ENSP00000295463 | ENSP00000280362 | Alkaline phosphatase, intestinal | 6-pyruvoyl tetrahydrobiopterin synthase; Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6- pyruvoyl tetrahydropterin; Belongs to the PTPS family | 0.917 |
ALPI | THY1 | ENSP00000295463 | ENSP00000284240 | Alkaline phosphatase, intestinal | Thy-1 membrane glycoprotein; May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain; CD molecules | 0.921 |
ALPI | XPNPEP2 | ENSP00000295463 | ENSP00000360147 | Alkaline phosphatase, intestinal | Xaa-Pro aminopeptidase 2; Membrane-bound metalloprotease which catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro. May play a role in the metabolism of the vasodilator bradykinin; Belongs to the peptidase M24B family | 0.919 |
ALPPL2 | ALPI | ENSP00000295453 | ENSP00000295463 | Alkaline phosphatase, placental like 2 | Alkaline phosphatase, intestinal | 0.968 |
ALPPL2 | CEACAM5 | ENSP00000295453 | ENSP00000221992 | Alkaline phosphatase, placental like 2 | Carcinoembryonic antigen-related cell adhesion molecule 5; Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins; CD molecules | 0.913 |
ALPPL2 | GCH1 | ENSP00000295453 | ENSP00000419045 | Alkaline phosphatase, placental like 2 | GTP cyclohydrolase 1; Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown; Belongs to the GTP cyclohydrolase I family | 0.910 |
ALPPL2 | GPLD1 | ENSP00000295453 | ENSP00000230036 | Alkaline phosphatase, placental like 2 | Phosphatidylinositol-glycan-specific phospholipase D; This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane | 0.910 |
ALPPL2 | LYPD8 | ENSP00000295453 | ENSP00000466070 | Alkaline phosphatase, placental like 2 | Ly6/PLAUR domain-containing protein 8; Secreted protein specifically required to prevent invasion of Gram-negative bacteria in the inner mucus layer of the colon epithelium, a portion of the large intestine which is free of commensal microbiota. Prevents invasion of flagellated microbiota by binding to the flagellum of bacteria, such as P.mirabilis, thereby inhibiting bacterial motility in the intestinal lumen. Segregation of intestinal bacteria and epithelial cells in the colon is required to preserve intestinal homeostasis; LY6/PLAUR domain containing | 0.902 |
ALPPL2 | NTPCR | ENSP00000295453 | ENSP00000355587 | Alkaline phosphatase, placental like 2 | Cancer-related nucleoside-triphosphatase; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphates with lower efficiency; Belongs to the THEP1 NTPase family | 0.910 |
ALPPL2 | PTS | ENSP00000295453 | ENSP00000280362 | Alkaline phosphatase, placental like 2 | 6-pyruvoyl tetrahydrobiopterin synthase; Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6- pyruvoyl tetrahydropterin; Belongs to the PTPS family | 0.917 |
ALPPL2 | THY1 | ENSP00000295453 | ENSP00000284240 | Alkaline phosphatase, placental like 2 | Thy-1 membrane glycoprotein; May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain; CD molecules | 0.922 |
ALPPL2 | XPNPEP2 | ENSP00000295453 | ENSP00000360147 | Alkaline phosphatase, placental like 2 | Xaa-Pro aminopeptidase 2; Membrane-bound metalloprotease which catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro. May play a role in the metabolism of the vasodilator bradykinin; Belongs to the peptidase M24B family | 0.909 |
CEACAM5 | ALPI | ENSP00000221992 | ENSP00000295463 | Carcinoembryonic antigen-related cell adhesion molecule 5; Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins; CD molecules | Alkaline phosphatase, intestinal | 0.916 |