node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALPI | ALPPL2 | ENSP00000295463 | ENSP00000295453 | Alkaline phosphatase, intestinal | Alkaline phosphatase, placental like 2 | 0.968 |
ALPI | CEACAM5 | ENSP00000295463 | ENSP00000221992 | Alkaline phosphatase, intestinal | Carcinoembryonic antigen-related cell adhesion molecule 5; Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins; CD molecules | 0.916 |
ALPI | GCH1 | ENSP00000295463 | ENSP00000419045 | Alkaline phosphatase, intestinal | GTP cyclohydrolase 1; Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown; Belongs to the GTP cyclohydrolase I family | 0.910 |
ALPI | GPLD1 | ENSP00000295463 | ENSP00000230036 | Alkaline phosphatase, intestinal | Phosphatidylinositol-glycan-specific phospholipase D; This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane | 0.909 |
ALPI | NTPCR | ENSP00000295463 | ENSP00000355587 | Alkaline phosphatase, intestinal | Cancer-related nucleoside-triphosphatase; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphates with lower efficiency; Belongs to the THEP1 NTPase family | 0.910 |
ALPI | PTS | ENSP00000295463 | ENSP00000280362 | Alkaline phosphatase, intestinal | 6-pyruvoyl tetrahydrobiopterin synthase; Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6- pyruvoyl tetrahydropterin; Belongs to the PTPS family | 0.917 |
ALPI | TECTA | ENSP00000295463 | ENSP00000376543 | Alkaline phosphatase, intestinal | Alpha-tectorin; One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals; Deafness associated genes | 0.906 |
ALPI | TECTB | ENSP00000295463 | ENSP00000358430 | Alkaline phosphatase, intestinal | Beta-tectorin; One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals | 0.906 |
ALPI | THY1 | ENSP00000295463 | ENSP00000284240 | Alkaline phosphatase, intestinal | Thy-1 membrane glycoprotein; May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain; CD molecules | 0.921 |
ALPI | XPNPEP2 | ENSP00000295463 | ENSP00000360147 | Alkaline phosphatase, intestinal | Xaa-Pro aminopeptidase 2; Membrane-bound metalloprotease which catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro. May play a role in the metabolism of the vasodilator bradykinin; Belongs to the peptidase M24B family | 0.919 |
ALPPL2 | ALPI | ENSP00000295453 | ENSP00000295463 | Alkaline phosphatase, placental like 2 | Alkaline phosphatase, intestinal | 0.968 |
ALPPL2 | CEACAM5 | ENSP00000295453 | ENSP00000221992 | Alkaline phosphatase, placental like 2 | Carcinoembryonic antigen-related cell adhesion molecule 5; Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins; CD molecules | 0.913 |
ALPPL2 | GCH1 | ENSP00000295453 | ENSP00000419045 | Alkaline phosphatase, placental like 2 | GTP cyclohydrolase 1; Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown; Belongs to the GTP cyclohydrolase I family | 0.910 |
ALPPL2 | GPLD1 | ENSP00000295453 | ENSP00000230036 | Alkaline phosphatase, placental like 2 | Phosphatidylinositol-glycan-specific phospholipase D; This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane | 0.910 |
ALPPL2 | NTPCR | ENSP00000295453 | ENSP00000355587 | Alkaline phosphatase, placental like 2 | Cancer-related nucleoside-triphosphatase; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphates with lower efficiency; Belongs to the THEP1 NTPase family | 0.910 |
ALPPL2 | PTS | ENSP00000295453 | ENSP00000280362 | Alkaline phosphatase, placental like 2 | 6-pyruvoyl tetrahydrobiopterin synthase; Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6- pyruvoyl tetrahydropterin; Belongs to the PTPS family | 0.917 |
ALPPL2 | TECTA | ENSP00000295453 | ENSP00000376543 | Alkaline phosphatase, placental like 2 | Alpha-tectorin; One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals; Deafness associated genes | 0.906 |
ALPPL2 | TECTB | ENSP00000295453 | ENSP00000358430 | Alkaline phosphatase, placental like 2 | Beta-tectorin; One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals | 0.903 |
ALPPL2 | THY1 | ENSP00000295453 | ENSP00000284240 | Alkaline phosphatase, placental like 2 | Thy-1 membrane glycoprotein; May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain; CD molecules | 0.922 |
ALPPL2 | XPNPEP2 | ENSP00000295453 | ENSP00000360147 | Alkaline phosphatase, placental like 2 | Xaa-Pro aminopeptidase 2; Membrane-bound metalloprotease which catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro. May play a role in the metabolism of the vasodilator bradykinin; Belongs to the peptidase M24B family | 0.909 |