node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FIGN | STPG2 | ENSP00000333836 | ENSP00000295268 | Fidgetin; ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, that may lead to the suppression of microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chr [...] | Sperm-tail PG-rich repeat-containing protein 2; Sperm tail PG-rich repeat containing 2 | 0.475 |
INSC | STPG2 | ENSP00000368872 | ENSP00000295268 | Protein inscuteable homolog; May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex. Involved in spindle orientation during mitosis. May regulate cell proliferation and differentiation in the developing nervous system. May play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the squamous epithelium (By similarity); Armadillo-like helical domain containing | Sperm-tail PG-rich repeat-containing protein 2; Sperm tail PG-rich repeat containing 2 | 0.439 |
LRRC6 | SAMD13 | ENSP00000484634 | ENSP00000359707 | Protein tilB homolog; May play a role in dynein arm assembly, hence essential for proper axoneme building for cilia motility | Sterile alpha motif domain containing 13 | 0.483 |
LRRC6 | STPG2 | ENSP00000484634 | ENSP00000295268 | Protein tilB homolog; May play a role in dynein arm assembly, hence essential for proper axoneme building for cilia motility | Sperm-tail PG-rich repeat-containing protein 2; Sperm tail PG-rich repeat containing 2 | 0.451 |
MYO1F | STPG2 | ENSP00000344871 | ENSP00000295268 | Unconventional myosin-If; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity); Myosins, class I | Sperm-tail PG-rich repeat-containing protein 2; Sperm tail PG-rich repeat containing 2 | 0.444 |
NDUFV3 | STPG2 | ENSP00000346196 | ENSP00000295268 | NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I | Sperm-tail PG-rich repeat-containing protein 2; Sperm tail PG-rich repeat containing 2 | 0.441 |
NDUFV3 | WDR4 | ENSP00000346196 | ENSP00000381266 | NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I | tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4; Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit; Belongs to the WD repeat TRM82 family | 0.579 |
RASIP1 | STPG2 | ENSP00000222145 | ENSP00000295268 | Ras-interacting protein 1; Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells (By similarity). May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRA [...] | Sperm-tail PG-rich repeat-containing protein 2; Sperm tail PG-rich repeat containing 2 | 0.422 |
SAMD13 | LRRC6 | ENSP00000359707 | ENSP00000484634 | Sterile alpha motif domain containing 13 | Protein tilB homolog; May play a role in dynein arm assembly, hence essential for proper axoneme building for cilia motility | 0.483 |
SAMD13 | STPG2 | ENSP00000359707 | ENSP00000295268 | Sterile alpha motif domain containing 13 | Sperm-tail PG-rich repeat-containing protein 2; Sperm tail PG-rich repeat containing 2 | 0.540 |
SLC7A8 | STPG2 | ENSP00000320378 | ENSP00000295268 | Large neutral amino acids transporter small subunit 2; Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administe [...] | Sperm-tail PG-rich repeat-containing protein 2; Sperm tail PG-rich repeat containing 2 | 0.486 |
STPG2 | FIGN | ENSP00000295268 | ENSP00000333836 | Sperm-tail PG-rich repeat-containing protein 2; Sperm tail PG-rich repeat containing 2 | Fidgetin; ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, that may lead to the suppression of microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chr [...] | 0.475 |
STPG2 | INSC | ENSP00000295268 | ENSP00000368872 | Sperm-tail PG-rich repeat-containing protein 2; Sperm tail PG-rich repeat containing 2 | Protein inscuteable homolog; May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex. Involved in spindle orientation during mitosis. May regulate cell proliferation and differentiation in the developing nervous system. May play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the squamous epithelium (By similarity); Armadillo-like helical domain containing | 0.439 |
STPG2 | LRRC6 | ENSP00000295268 | ENSP00000484634 | Sperm-tail PG-rich repeat-containing protein 2; Sperm tail PG-rich repeat containing 2 | Protein tilB homolog; May play a role in dynein arm assembly, hence essential for proper axoneme building for cilia motility | 0.451 |
STPG2 | MYO1F | ENSP00000295268 | ENSP00000344871 | Sperm-tail PG-rich repeat-containing protein 2; Sperm tail PG-rich repeat containing 2 | Unconventional myosin-If; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity); Myosins, class I | 0.444 |
STPG2 | NDUFV3 | ENSP00000295268 | ENSP00000346196 | Sperm-tail PG-rich repeat-containing protein 2; Sperm tail PG-rich repeat containing 2 | NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I | 0.441 |
STPG2 | RASIP1 | ENSP00000295268 | ENSP00000222145 | Sperm-tail PG-rich repeat-containing protein 2; Sperm tail PG-rich repeat containing 2 | Ras-interacting protein 1; Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells (By similarity). May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRA [...] | 0.422 |
STPG2 | SAMD13 | ENSP00000295268 | ENSP00000359707 | Sperm-tail PG-rich repeat-containing protein 2; Sperm tail PG-rich repeat containing 2 | Sterile alpha motif domain containing 13 | 0.540 |
STPG2 | SLC7A8 | ENSP00000295268 | ENSP00000320378 | Sperm-tail PG-rich repeat-containing protein 2; Sperm tail PG-rich repeat containing 2 | Large neutral amino acids transporter small subunit 2; Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administe [...] | 0.486 |
STPG2 | TPK1 | ENSP00000295268 | ENSP00000353165 | Sperm-tail PG-rich repeat-containing protein 2; Sperm tail PG-rich repeat containing 2 | Thiamin pyrophosphokinase 1; Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate | 0.468 |