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STRINGSTRING
TRIM28 TRIM28 POLE4 POLE4 FAHD2B FAHD2B ZNF514 ZNF514 GPR45 GPR45 ANKRD39 ANKRD39 FAM178B FAM178B MRPS9 MRPS9 FAHD2A FAHD2A MRPS5 MRPS5 YTHDC2 YTHDC2
"ZNF514" - Zinc finger protein 514 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ZNF514Zinc finger protein 514; May be involved in transcriptional regulation; Zinc fingers C2H2-type (400 aa)    
Predicted Functional Partners:
TRIM28
Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] (835 aa)
      
    0.903
MRPS5
Mitochondrial ribosomal protein S5 (430 aa)
            
  0.568
FAHD2B
Fumarylacetoacetate hydrolase domain-containing protein 2B; May have hydrolase activity (314 aa)
        
 
  0.562
POLE4
DNA polymerase epsilon subunit 4; May play a role in allowing polymerase epsilon to carry out its replication and/or repair function; DNA polymerases (117 aa)
      
 
  0.551
FAHD2A
Fumarylacetoacetate hydrolase domain-containing protein 2A; May have hydrolase activity (314 aa)
        
 
  0.547
FAM178B
Protein FAM178B; Family with sequence similarity 178 member B (679 aa)
            
  0.541
ANKRD39
Ankyrin repeat domain-containing protein 39; Ankyrin repeat domain containing; Belongs to the ANKRD39 family (183 aa)
      
 
  0.537
MRPS9
Mitochondrial ribosomal protein S9 (396 aa)
            
  0.526
YTHDC2
Probable ATP-dependent RNA helicase YTHDC2; Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs affecting the translation efficiency and mRNA abundance of its targets. Is required for proper spermatocyte development (By similarity). M6A is a modification present at internal sites of mRNAs and some non- coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability. When associated with MEIOC, binds transcripts that regulate the mitotic cell cycle inhibiting progression into metaphase, thereby allowing meiotic prophase to proceed normall [...] (1430 aa)
        
 
  0.524
GPR45
Probable G-protein coupled receptor 45; Orphan receptor. May play a role in brain function; G protein-coupled receptors, Class A orphans (372 aa)
        
 
  0.522
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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