CCDC74A protein (human) - STRING database

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CCDC74A

Coiled-coil domain containing 74A (378 aa)

Predicted Functional Partners:

CFAP57

0.622

TMEM56

0.597

RBMXL2

0.559

SLC25A21

0.542

VWCE

0.516

IGSF11

0.514

REEP6

0.501

SMCR8

0.500

ERCC6L

0.474

SLC51A

0.471

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCDC74A	CFAP57	ENSP00000295171	ENSP00000479773	Coiled-coil domain containing 74A	Cilia and flagella associated protein 57	0.622
CCDC74A	ERCC6L	ENSP00000295171	ENSP00000334675	Coiled-coil domain containing 74A	DNA excision repair protein ERCC-6-like; DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. Functions as ATP-dependent DNA translocase. Can promote Holliday junction branch migration (in vitro)	0.474
CCDC74A	IGSF11	ENSP00000295171	ENSP00000377370	Coiled-coil domain containing 74A	Immunoglobulin superfamily member 11; Functions as a cell adhesion molecule through homophilic interaction. Stimulates cell growth; I-set domain containing	0.514
CCDC74A	RBMXL2	ENSP00000295171	ENSP00000304139	Coiled-coil domain containing 74A	RNA binding motif protein, X-linked like 2	0.559
CCDC74A	REEP6	ENSP00000295171	ENSP00000233596	Coiled-coil domain containing 74A	Receptor accessory protein 6	0.501
CCDC74A	SLC25A21	ENSP00000295171	ENSP00000329452	Coiled-coil domain containing 74A	Mitochondrial 2-oxodicarboxylate carrier; Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2- oxoglutarate, adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, and citrate; Belongs to the mitochondrial carrier (TC 2.A.29) family	0.542
CCDC74A	SLC51A	ENSP00000295171	ENSP00000296327	Coiled-coil domain containing 74A	Organic solute transporter subunit alpha; Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids; Solute carriers	0.471
CCDC74A	SMCR8	ENSP00000295171	ENSP00000385025	Coiled-coil domain containing 74A	Guanine nucleotide exchange protein SMCR8; Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activ [...]	0.500
CCDC74A	TMEM56	ENSP00000295171	ENSP00000359222	Coiled-coil domain containing 74A	Transmembrane protein 56; TLC domain containing	0.597
CCDC74A	VWCE	ENSP00000295171	ENSP00000334186	Coiled-coil domain containing 74A	Von Willebrand factor C and EGF domain-containing protein; May be a regulatory element in the beta-catenin signaling pathway and a target for chemoprevention of hapatocellular carcinoma	0.516
CFAP57	CCDC74A	ENSP00000479773	ENSP00000295171	Cilia and flagella associated protein 57	Coiled-coil domain containing 74A	0.622
CFAP57	ERCC6L	ENSP00000479773	ENSP00000334675	Cilia and flagella associated protein 57	DNA excision repair protein ERCC-6-like; DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. Functions as ATP-dependent DNA translocase. Can promote Holliday junction branch migration (in vitro)	0.466
CFAP57	IGSF11	ENSP00000479773	ENSP00000377370	Cilia and flagella associated protein 57	Immunoglobulin superfamily member 11; Functions as a cell adhesion molecule through homophilic interaction. Stimulates cell growth; I-set domain containing	0.474
CFAP57	RBMXL2	ENSP00000479773	ENSP00000304139	Cilia and flagella associated protein 57	RNA binding motif protein, X-linked like 2	0.435
CFAP57	REEP6	ENSP00000479773	ENSP00000233596	Cilia and flagella associated protein 57	Receptor accessory protein 6	0.459
CFAP57	SLC25A21	ENSP00000479773	ENSP00000329452	Cilia and flagella associated protein 57	Mitochondrial 2-oxodicarboxylate carrier; Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2- oxoglutarate, adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, and citrate; Belongs to the mitochondrial carrier (TC 2.A.29) family	0.591
CFAP57	SLC51A	ENSP00000479773	ENSP00000296327	Cilia and flagella associated protein 57	Organic solute transporter subunit alpha; Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids; Solute carriers	0.416
CFAP57	SMCR8	ENSP00000479773	ENSP00000385025	Cilia and flagella associated protein 57	Guanine nucleotide exchange protein SMCR8; Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activ [...]	0.471
CFAP57	TMEM56	ENSP00000479773	ENSP00000359222	Cilia and flagella associated protein 57	Transmembrane protein 56; TLC domain containing	0.554
ERCC6L	CCDC74A	ENSP00000334675	ENSP00000295171	DNA excision repair protein ERCC-6-like; DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. Functions as ATP-dependent DNA translocase. Can promote Holliday junction branch migration (in vitro)	Coiled-coil domain containing 74A	0.474

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