FAM228A protein (human) - STRING database

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FAM228A

Protein FAM228A; Family with sequence similarity 228 member A; Belongs to the FAM228 family (206 aa)

Predicted Functional Partners:

RFX8

0.646

TMEM71

0.645

PFN4

0.633

SPATA17

0.585

FAM174B

0.583

GDPD4

0.557

ITSN2

0.543

DHX35

0.538

CEP162

0.533

TPRA1

0.529

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CEP162	FAM228A	ENSP00000385215	ENSP00000295150	Centrosomal protein of 162 kDa; Required to promote assembly of the transition zone in primary cilia. Acts by specifically recognizing and binding the axonemal microtubule. Localizes to the distal ends of centrioles before ciliogenesis and directly binds to axonemal microtubule, thereby promoting and restricting transition zone formation specifically at the cilia base. Required to mediate CEP290 association with microtubules; Belongs to the CEP162 family	Protein FAM228A; Family with sequence similarity 228 member A; Belongs to the FAM228 family	0.533
CEP162	RFX8	ENSP00000385215	ENSP00000401536	Centrosomal protein of 162 kDa; Required to promote assembly of the transition zone in primary cilia. Acts by specifically recognizing and binding the axonemal microtubule. Localizes to the distal ends of centrioles before ciliogenesis and directly binds to axonemal microtubule, thereby promoting and restricting transition zone formation specifically at the cilia base. Required to mediate CEP290 association with microtubules; Belongs to the CEP162 family	DNA-binding protein RFX8; May be a transcription factor; Regulatory factor X family	0.400
CEP162	TMEM71	ENSP00000385215	ENSP00000349296	Centrosomal protein of 162 kDa; Required to promote assembly of the transition zone in primary cilia. Acts by specifically recognizing and binding the axonemal microtubule. Localizes to the distal ends of centrioles before ciliogenesis and directly binds to axonemal microtubule, thereby promoting and restricting transition zone formation specifically at the cilia base. Required to mediate CEP290 association with microtubules; Belongs to the CEP162 family	Transmembrane protein 71; Belongs to the TMEM71 family	0.400
DHX35	FAM228A	ENSP00000252011	ENSP00000295150	Probable ATP-dependent RNA helicase DHX35; May be involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily	Protein FAM228A; Family with sequence similarity 228 member A; Belongs to the FAM228 family	0.538
DHX35	RFX8	ENSP00000252011	ENSP00000401536	Probable ATP-dependent RNA helicase DHX35; May be involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily	DNA-binding protein RFX8; May be a transcription factor; Regulatory factor X family	0.412
DHX35	SPATA17	ENSP00000252011	ENSP00000355900	Probable ATP-dependent RNA helicase DHX35; May be involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily	Spermatogenesis-associated protein 17; Spermatogenesis associated 17	0.422
DHX35	TMEM71	ENSP00000252011	ENSP00000349296	Probable ATP-dependent RNA helicase DHX35; May be involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily	Transmembrane protein 71; Belongs to the TMEM71 family	0.412
FAM174B	FAM228A	ENSP00000329040	ENSP00000295150	Membrane protein FAM174B; Family with sequence similarity 174 member B	Protein FAM228A; Family with sequence similarity 228 member A; Belongs to the FAM228 family	0.583
FAM174B	RFX8	ENSP00000329040	ENSP00000401536	Membrane protein FAM174B; Family with sequence similarity 174 member B	DNA-binding protein RFX8; May be a transcription factor; Regulatory factor X family	0.470
FAM174B	SPATA17	ENSP00000329040	ENSP00000355900	Membrane protein FAM174B; Family with sequence similarity 174 member B	Spermatogenesis-associated protein 17; Spermatogenesis associated 17	0.420
FAM174B	TMEM71	ENSP00000329040	ENSP00000349296	Membrane protein FAM174B; Family with sequence similarity 174 member B	Transmembrane protein 71; Belongs to the TMEM71 family	0.470
FAM228A	CEP162	ENSP00000295150	ENSP00000385215	Protein FAM228A; Family with sequence similarity 228 member A; Belongs to the FAM228 family	Centrosomal protein of 162 kDa; Required to promote assembly of the transition zone in primary cilia. Acts by specifically recognizing and binding the axonemal microtubule. Localizes to the distal ends of centrioles before ciliogenesis and directly binds to axonemal microtubule, thereby promoting and restricting transition zone formation specifically at the cilia base. Required to mediate CEP290 association with microtubules; Belongs to the CEP162 family	0.533
FAM228A	DHX35	ENSP00000295150	ENSP00000252011	Protein FAM228A; Family with sequence similarity 228 member A; Belongs to the FAM228 family	Probable ATP-dependent RNA helicase DHX35; May be involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily	0.538
FAM228A	FAM174B	ENSP00000295150	ENSP00000329040	Protein FAM228A; Family with sequence similarity 228 member A; Belongs to the FAM228 family	Membrane protein FAM174B; Family with sequence similarity 174 member B	0.583
FAM228A	GDPD4	ENSP00000295150	ENSP00000320815	Protein FAM228A; Family with sequence similarity 228 member A; Belongs to the FAM228 family	Glycerophosphodiester phosphodiesterase domain containing 4; Belongs to the glycerophosphoryl diester phosphodiesterase family	0.557
FAM228A	ITSN2	ENSP00000295150	ENSP00000347244	Protein FAM228A; Family with sequence similarity 228 member A; Belongs to the FAM228 family	Intersectin-2; Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes; C2 domain containing	0.543
FAM228A	PFN4	ENSP00000295150	ENSP00000322170	Protein FAM228A; Family with sequence similarity 228 member A; Belongs to the FAM228 family	Profilin-4; Binds to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidic acid (PA). Does not bind to actin, contrary to other family members; Belongs to the profilin family	0.633
FAM228A	RFX8	ENSP00000295150	ENSP00000401536	Protein FAM228A; Family with sequence similarity 228 member A; Belongs to the FAM228 family	DNA-binding protein RFX8; May be a transcription factor; Regulatory factor X family	0.646
FAM228A	SPATA17	ENSP00000295150	ENSP00000355900	Protein FAM228A; Family with sequence similarity 228 member A; Belongs to the FAM228 family	Spermatogenesis-associated protein 17; Spermatogenesis associated 17	0.585
FAM228A	TMEM71	ENSP00000295150	ENSP00000349296	Protein FAM228A; Family with sequence similarity 228 member A; Belongs to the FAM228 family	Transmembrane protein 71; Belongs to the TMEM71 family	0.645

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