CCDC138 protein (human) - STRING database

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

CCDC138

Coiled-coil domain containing 138 (665 aa)

Predicted Functional Partners:

PIBF1

0.784

CCDC61

0.774

WDR90

0.747

KIAA1328

0.744

SSX2IP

0.735

ANKRD55

0.718

TTLL5

0.699

TBC1D31

0.662

OFD1

0.556

RBM27

0.544

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKRD55	CCDC138	ENSP00000342295	ENSP00000295124	Ankyrin repeat domain-containing protein 55; Ankyrin repeat domain containing	Coiled-coil domain containing 138	0.718
ANKRD55	CCDC61	ENSP00000342295	ENSP00000471454	Ankyrin repeat domain-containing protein 55; Ankyrin repeat domain containing	Coiled-coil domain containing 61	0.445
ANKRD55	KIAA1328	ENSP00000342295	ENSP00000280020	Ankyrin repeat domain-containing protein 55; Ankyrin repeat domain containing	Protein hinderin; Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes	0.723
ANKRD55	PIBF1	ENSP00000342295	ENSP00000317144	Ankyrin repeat domain-containing protein 55; Ankyrin repeat domain containing	Progesterone-induced-blocking factor 1; Isoform 1- Pericentriolar protein required to maintain mitotic spindle pole integrity. Required for the centrosomal accumulation of PCM1 and the recruitment of centriolar satellite proteins such as BBS4. Via association with PCM1 may be involved in primary cilia formation. Required for CEP63 centrosomal localization and its interaction with WDR62. Together with CEP63 promotes centriole duplication. Promotes the centrosomal localization of CDK2	0.436
ANKRD55	SSX2IP	ENSP00000342295	ENSP00000340279	Ankyrin repeat domain-containing protein 55; Ankyrin repeat domain containing	Afadin- and alpha-actinin-binding protein; Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E- cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin (By similarity). Involved in cell movement- localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via a [...]	0.416
ANKRD55	TTLL5	ENSP00000342295	ENSP00000298832	Ankyrin repeat domain-containing protein 55; Ankyrin repeat domain containing	Tubulin polyglutamylase TTLL5; Polyglutamylase which preferentially modifies alpha- tubulin. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity). Required for CCSAP localization to both spindle and cilia microtubules. Increases the effects of NCOA2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction; Tubulin tyrosine ligase family	0.440
ANKRD55	WDR90	ENSP00000342295	ENSP00000293879	Ankyrin repeat domain-containing protein 55; Ankyrin repeat domain containing	WD repeat-containing protein 90; WD repeat domain containing	0.744
CCDC138	ANKRD55	ENSP00000295124	ENSP00000342295	Coiled-coil domain containing 138	Ankyrin repeat domain-containing protein 55; Ankyrin repeat domain containing	0.718
CCDC138	CCDC61	ENSP00000295124	ENSP00000471454	Coiled-coil domain containing 138	Coiled-coil domain containing 61	0.774
CCDC138	KIAA1328	ENSP00000295124	ENSP00000280020	Coiled-coil domain containing 138	Protein hinderin; Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes	0.744
CCDC138	OFD1	ENSP00000295124	ENSP00000344314	Coiled-coil domain containing 138	Oral-facial-digital syndrome 1 protein; Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164. Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis. Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriol [...]	0.556
CCDC138	PIBF1	ENSP00000295124	ENSP00000317144	Coiled-coil domain containing 138	Progesterone-induced-blocking factor 1; Isoform 1- Pericentriolar protein required to maintain mitotic spindle pole integrity. Required for the centrosomal accumulation of PCM1 and the recruitment of centriolar satellite proteins such as BBS4. Via association with PCM1 may be involved in primary cilia formation. Required for CEP63 centrosomal localization and its interaction with WDR62. Together with CEP63 promotes centriole duplication. Promotes the centrosomal localization of CDK2	0.784
CCDC138	RBM27	ENSP00000295124	ENSP00000265271	Coiled-coil domain containing 138	RNA-binding protein 27; RNA binding motif containing	0.544
CCDC138	SSX2IP	ENSP00000295124	ENSP00000340279	Coiled-coil domain containing 138	Afadin- and alpha-actinin-binding protein; Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E- cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin (By similarity). Involved in cell movement- localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via a [...]	0.735
CCDC138	TBC1D31	ENSP00000295124	ENSP00000287380	Coiled-coil domain containing 138	TBC1 domain family member 31; WD repeat domain containing	0.662
CCDC138	TTLL5	ENSP00000295124	ENSP00000298832	Coiled-coil domain containing 138	Tubulin polyglutamylase TTLL5; Polyglutamylase which preferentially modifies alpha- tubulin. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity). Required for CCSAP localization to both spindle and cilia microtubules. Increases the effects of NCOA2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction; Tubulin tyrosine ligase family	0.699
CCDC138	WDR90	ENSP00000295124	ENSP00000293879	Coiled-coil domain containing 138	WD repeat-containing protein 90; WD repeat domain containing	0.747
CCDC61	ANKRD55	ENSP00000471454	ENSP00000342295	Coiled-coil domain containing 61	Ankyrin repeat domain-containing protein 55; Ankyrin repeat domain containing	0.445
CCDC61	CCDC138	ENSP00000471454	ENSP00000295124	Coiled-coil domain containing 61	Coiled-coil domain containing 138	0.774
CCDC61	KIAA1328	ENSP00000471454	ENSP00000280020	Coiled-coil domain containing 61	Protein hinderin; Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes	0.766

page 1 of 5

Network

Cooccurrence

Experiments

Coexpression

Textmining

Neighborhood

Databases

Fusion

© STRING Consortium 2020

Credits

Access

Info

About