node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ETAA1 | FAM84A | ENSP00000272342 | ENSP00000295092 | Ewing’s tumor-associated antigen 1; Replication stress response protein that accumulates at DNA damage sites and promotes replication fork progression and integrity. Recruited to stalled replication forks via interaction with the RPA complex and directly stimulates ATR kinase activity independently of TOPBP1. Probably only regulates a subset of ATR targets | Protein FAM84A; Family with sequence similarity 84 member A | 0.615 |
FAM49A | FAM84A | ENSP00000370724 | ENSP00000295092 | Protein FAM49A; Family with sequence similarity 49 member A; Belongs to the FAM49 family | Protein FAM84A; Family with sequence similarity 84 member A | 0.786 |
FAM49A | PRELID1 | ENSP00000370724 | ENSP00000302114 | Protein FAM49A; Family with sequence similarity 49 member A; Belongs to the FAM49 family | PRELI domain-containing protein 1, mitochondrial; Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1-PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Regulates the mitochondrial apoptotic pathway in primary Th cells. Regulates Th cell differentiation by down-regulating STAT6 thereby reducing IL-4-induce [...] | 0.651 |
FAM49A | VPS37D | ENSP00000370724 | ENSP00000320416 | Protein FAM49A; Family with sequence similarity 49 member A; Belongs to the FAM49 family | Vacuolar protein sorting-associated protein 37D; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation; Belongs to the VPS37 family | 0.617 |
FAM84A | ETAA1 | ENSP00000295092 | ENSP00000272342 | Protein FAM84A; Family with sequence similarity 84 member A | Ewing’s tumor-associated antigen 1; Replication stress response protein that accumulates at DNA damage sites and promotes replication fork progression and integrity. Recruited to stalled replication forks via interaction with the RPA complex and directly stimulates ATR kinase activity independently of TOPBP1. Probably only regulates a subset of ATR targets | 0.615 |
FAM84A | FAM49A | ENSP00000295092 | ENSP00000370724 | Protein FAM84A; Family with sequence similarity 84 member A | Protein FAM49A; Family with sequence similarity 49 member A; Belongs to the FAM49 family | 0.786 |
FAM84A | HRASLS | ENSP00000295092 | ENSP00000264735 | Protein FAM84A; Family with sequence similarity 84 member A | Phospholipid-metabolizing enzyme A-C1; Exhibits calcium-independent phospholipase activity towards phosphatidylcholine (PC) and phosphatidylethanolamine (PE). Also shows acyltransferase activities, transferring an acyl group of PCs to the amino group of PEs and the hydroxyl group of lyso PCs; HRAS like suppressor family | 0.725 |
FAM84A | KYNU | ENSP00000295092 | ENSP00000264170 | Protein FAM84A; Family with sequence similarity 84 member A | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity | 0.545 |
FAM84A | LRAT | ENSP00000295092 | ENSP00000337224 | Protein FAM84A; Family with sequence similarity 84 member A | Lecithin retinol acyltransferase; Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A. LRAT plays a critical role in vision. It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments; [...] | 0.531 |
FAM84A | PRELID1 | ENSP00000295092 | ENSP00000302114 | Protein FAM84A; Family with sequence similarity 84 member A | PRELI domain-containing protein 1, mitochondrial; Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1-PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Regulates the mitochondrial apoptotic pathway in primary Th cells. Regulates Th cell differentiation by down-regulating STAT6 thereby reducing IL-4-induce [...] | 0.567 |
FAM84A | SF3B3 | ENSP00000295092 | ENSP00000305790 | Protein FAM84A; Family with sequence similarity 84 member A | Splicing factor 3B subunit 3; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron | 0.651 |
FAM84A | STK32A | ENSP00000295092 | ENSP00000381535 | Protein FAM84A; Family with sequence similarity 84 member A | Serine/threonine kinase 32A | 0.594 |
FAM84A | VPS37D | ENSP00000295092 | ENSP00000320416 | Protein FAM84A; Family with sequence similarity 84 member A | Vacuolar protein sorting-associated protein 37D; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation; Belongs to the VPS37 family | 0.538 |
FAM84A | ZNF415 | ENSP00000295092 | ENSP00000439435 | Protein FAM84A; Family with sequence similarity 84 member A | Zinc finger protein 415; Involved in transcriptional regulation. Transcriptional activity differed among the various isoforms. All isoforms except isoform 3 seem to suppresses the transcriptional activities of AP- 1 and p53/TP53; Zinc fingers C2H2-type | 0.541 |
HRASLS | FAM84A | ENSP00000264735 | ENSP00000295092 | Phospholipid-metabolizing enzyme A-C1; Exhibits calcium-independent phospholipase activity towards phosphatidylcholine (PC) and phosphatidylethanolamine (PE). Also shows acyltransferase activities, transferring an acyl group of PCs to the amino group of PEs and the hydroxyl group of lyso PCs; HRAS like suppressor family | Protein FAM84A; Family with sequence similarity 84 member A | 0.725 |
KYNU | FAM84A | ENSP00000264170 | ENSP00000295092 | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity | Protein FAM84A; Family with sequence similarity 84 member A | 0.545 |
KYNU | SF3B3 | ENSP00000264170 | ENSP00000305790 | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity | Splicing factor 3B subunit 3; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron | 0.693 |
LRAT | FAM84A | ENSP00000337224 | ENSP00000295092 | Lecithin retinol acyltransferase; Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A. LRAT plays a critical role in vision. It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments; [...] | Protein FAM84A; Family with sequence similarity 84 member A | 0.531 |
PRELID1 | FAM49A | ENSP00000302114 | ENSP00000370724 | PRELI domain-containing protein 1, mitochondrial; Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1-PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Regulates the mitochondrial apoptotic pathway in primary Th cells. Regulates Th cell differentiation by down-regulating STAT6 thereby reducing IL-4-induce [...] | Protein FAM49A; Family with sequence similarity 49 member A; Belongs to the FAM49 family | 0.651 |
PRELID1 | FAM84A | ENSP00000302114 | ENSP00000295092 | PRELI domain-containing protein 1, mitochondrial; Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1-PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Regulates the mitochondrial apoptotic pathway in primary Th cells. Regulates Th cell differentiation by down-regulating STAT6 thereby reducing IL-4-induce [...] | Protein FAM84A; Family with sequence similarity 84 member A | 0.567 |