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STRINGSTRING
YOD1 YOD1 DIEXF DIEXF FAM72A FAM72A C1orf186 C1orf186 G0S2 G0S2 C1orf74 C1orf74 EIF2D EIF2D TRAF3IP3 TRAF3IP3 AZIN1 AZIN1 CCDC176 CCDC176 C1orf116 C1orf116
"C1orf74" - UPF0739 protein C1orf74 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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[Homology]
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C1orf74UPF0739 protein C1orf74; Chromosome 1 open reading frame 74; Belongs to the UPF0739 family (269 aa)    
Predicted Functional Partners:
CCDC176
Basal body-orientation factor 1; Basal body protein required in multiciliate cells to align and maintain cilia orientation in response to flow. May act by mediating a maturation step that stabilizes and aligns cilia orientation. Not required to respond to planar cell polarity (PCP) or flow-based orientation cues (By similarity) (529 aa)
            
  0.646
C1orf186
Uncharacterized protein C1orf186; Chromosome 1 open reading frame 186 (172 aa)
            
  0.632
TRAF3IP3
TRAF3-interacting JNK-activating modulator; May function as an adapter molecule that regulates TRAF3-mediated JNK activation (551 aa)
            
  0.542
EIF2D
Eukaryotic translation initiation factor 2D; Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P- site of the 40S subunit. In addition to its [...] (584 aa)
            
  0.528
C1orf116
Specifically androgen-regulated gene protein; Putative androgen-specific receptor; Belongs to the SARG family (601 aa)
            
  0.491
FAM72A
Protein FAM72A; May play a role in the regulation of cellular reactive oxygen species metabolism. May participate in cell growth regulation; Belongs to the FAM72 family (149 aa)
            
  0.479
DIEXF
Digestive organ expansion factor homolog; Regulates the p53 pathway to control the expansion growth of digestive organs (756 aa)
            
  0.474
YOD1
Ubiquitin thioesterase OTU1; Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP’s axial channel. Mediates deubiquitination of ’Lys-27’-, ’Lys-29’- and ’Lys-33’-linked polyubiquitin chains. A [...] (348 aa)
            
  0.440
G0S2
G0/G1 switch protein 2; Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers (103 aa)
            
  0.424
AZIN1
Antizyme inhibitor 1; Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme- binding. Inhibits antizyme- dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production (448 aa)
            
  0.420
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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