| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANAPC11 | C1orf123 | ENSP00000349957 | ENSP00000294360 | Anaphase promoting complex subunit 11 | UPF0587 protein C1orf123; Chromosome 1 open reading frame 123; Belongs to the UPF0587 family | 0.820 |
| ANAPC11 | HINT1 | ENSP00000349957 | ENSP00000304229 | Anaphase promoting complex subunit 11 | Histidine triad nucleotide-binding protein 1; Hydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5’monophosphoramidate (AMP-NH2), adenosine 5’monophosphomorpholidate (AMP-morpholidate) and guanosine 5’monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His- AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. Can also convert adenosine 5’-O-phosphorothioate and guan [...] | 0.829 |
| ANAPC11 | UBA6 | ENSP00000349957 | ENSP00000313454 | Anaphase promoting complex subunit 11 | Ubiquitin-like modifier-activating enzyme 6; Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin- E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesi [...] | 0.915 |
| C1orf123 | ANAPC11 | ENSP00000294360 | ENSP00000349957 | UPF0587 protein C1orf123; Chromosome 1 open reading frame 123; Belongs to the UPF0587 family | Anaphase promoting complex subunit 11 | 0.820 |
| C1orf123 | DNAJC17 | ENSP00000294360 | ENSP00000220496 | UPF0587 protein C1orf123; Chromosome 1 open reading frame 123; Belongs to the UPF0587 family | DnaJ homolog subfamily C member 17; May negatively affect PAX8-induced thyroglobulin/TG transcription; DNAJ heat shock proteins | 0.808 |
| C1orf123 | GATSL2 | ENSP00000294360 | ENSP00000484732 | UPF0587 protein C1orf123; Chromosome 1 open reading frame 123; Belongs to the UPF0587 family | Cytosolic arginine sensor for mTORC1 subunit 2; Functions as a negative regulator of the TORC1 signaling pathway through the GATOR complex. As part of homodimers or heterodimers with CASTOR1, directly binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Does not directly bind arginine, but binding of arginine to CASTOR1 disrupts the interaction of CASTOR2-containing heterodimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway; Belongs to the GATS family | 0.510 |
| C1orf123 | GTPBP6 | ENSP00000294360 | ENSP00000316598 | UPF0587 protein C1orf123; Chromosome 1 open reading frame 123; Belongs to the UPF0587 family | Putative GTP-binding protein 6; Pseudoautosomal region 1 | 0.463 |
| C1orf123 | HINT1 | ENSP00000294360 | ENSP00000304229 | UPF0587 protein C1orf123; Chromosome 1 open reading frame 123; Belongs to the UPF0587 family | Histidine triad nucleotide-binding protein 1; Hydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5’monophosphoramidate (AMP-NH2), adenosine 5’monophosphomorpholidate (AMP-morpholidate) and guanosine 5’monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His- AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. Can also convert adenosine 5’-O-phosphorothioate and guan [...] | 0.536 |
| C1orf123 | MXRA7 | ENSP00000294360 | ENSP00000348050 | UPF0587 protein C1orf123; Chromosome 1 open reading frame 123; Belongs to the UPF0587 family | Matrix-remodeling-associated protein 7; Matrix remodeling associated 7 | 0.491 |
| C1orf123 | NDUFB6 | ENSP00000294360 | ENSP00000369176 | UPF0587 protein C1orf123; Chromosome 1 open reading frame 123; Belongs to the UPF0587 family | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone | 0.598 |
| C1orf123 | OARD1 | ENSP00000294360 | ENSP00000420484 | UPF0587 protein C1orf123; Chromosome 1 open reading frame 123; Belongs to the UPF0587 family | O-acetyl-ADP-ribose deacetylase 1; Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Catalyzes the deacylation of O- acetyl-ADP-ribose, O-propionyl-ADP-ribose and O-butyryl-ADP- ribose, yielding ADP-ribose plus acetate, propionate and butyrate, respectively | 0.457 |
| C1orf123 | SLC19A2 | ENSP00000294360 | ENSP00000236137 | UPF0587 protein C1orf123; Chromosome 1 open reading frame 123; Belongs to the UPF0587 family | Thiamine transporter 1; High-affinity transporter for the intake of thiamine; Solute carriers | 0.555 |
| C1orf123 | UBA6 | ENSP00000294360 | ENSP00000313454 | UPF0587 protein C1orf123; Chromosome 1 open reading frame 123; Belongs to the UPF0587 family | Ubiquitin-like modifier-activating enzyme 6; Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin- E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesi [...] | 0.442 |
| DNAJC17 | C1orf123 | ENSP00000220496 | ENSP00000294360 | DnaJ homolog subfamily C member 17; May negatively affect PAX8-induced thyroglobulin/TG transcription; DNAJ heat shock proteins | UPF0587 protein C1orf123; Chromosome 1 open reading frame 123; Belongs to the UPF0587 family | 0.808 |
| GATSL2 | C1orf123 | ENSP00000484732 | ENSP00000294360 | Cytosolic arginine sensor for mTORC1 subunit 2; Functions as a negative regulator of the TORC1 signaling pathway through the GATOR complex. As part of homodimers or heterodimers with CASTOR1, directly binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Does not directly bind arginine, but binding of arginine to CASTOR1 disrupts the interaction of CASTOR2-containing heterodimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway; Belongs to the GATS family | UPF0587 protein C1orf123; Chromosome 1 open reading frame 123; Belongs to the UPF0587 family | 0.510 |
| GTPBP6 | C1orf123 | ENSP00000316598 | ENSP00000294360 | Putative GTP-binding protein 6; Pseudoautosomal region 1 | UPF0587 protein C1orf123; Chromosome 1 open reading frame 123; Belongs to the UPF0587 family | 0.463 |
| HINT1 | ANAPC11 | ENSP00000304229 | ENSP00000349957 | Histidine triad nucleotide-binding protein 1; Hydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5’monophosphoramidate (AMP-NH2), adenosine 5’monophosphomorpholidate (AMP-morpholidate) and guanosine 5’monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His- AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. Can also convert adenosine 5’-O-phosphorothioate and guan [...] | Anaphase promoting complex subunit 11 | 0.829 |
| HINT1 | C1orf123 | ENSP00000304229 | ENSP00000294360 | Histidine triad nucleotide-binding protein 1; Hydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5’monophosphoramidate (AMP-NH2), adenosine 5’monophosphomorpholidate (AMP-morpholidate) and guanosine 5’monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His- AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. Can also convert adenosine 5’-O-phosphorothioate and guan [...] | UPF0587 protein C1orf123; Chromosome 1 open reading frame 123; Belongs to the UPF0587 family | 0.536 |
| MXRA7 | C1orf123 | ENSP00000348050 | ENSP00000294360 | Matrix-remodeling-associated protein 7; Matrix remodeling associated 7 | UPF0587 protein C1orf123; Chromosome 1 open reading frame 123; Belongs to the UPF0587 family | 0.491 |
| NDUFB6 | C1orf123 | ENSP00000369176 | ENSP00000294360 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone | UPF0587 protein C1orf123; Chromosome 1 open reading frame 123; Belongs to the UPF0587 family | 0.598 |
