CELA1 protein (human) - STRING database

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CELA1

Chymotrypsin-like elastase family member 1; Acts upon elastin (258 aa)

Predicted Functional Partners:

CPA1

0.716

SERPINA1

0.682

BLZF1

0.660

SCT

0.645

A2M

0.602

CPA6

0.589

SPINK1

0.572

AMY2A

0.565

CPB1

0.557

CPA5

0.546

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A2M	CELA1	ENSP00000323929	ENSP00000293636	Alpha-2-macroglobulin; Is able to inhibit all four classes of proteinases by a unique ’trapping’ mechanism. This protein has a peptide stretch, called the ’bait region’ which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the c [...]	Chymotrypsin-like elastase family member 1; Acts upon elastin	0.602
A2M	SERPINA1	ENSP00000323929	ENSP00000416066	Alpha-2-macroglobulin; Is able to inhibit all four classes of proteinases by a unique ’trapping’ mechanism. This protein has a peptide stretch, called the ’bait region’ which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the c [...]	Alpha-1-antitrypsin; Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin; Belongs to the serpin family	0.992
AMY2A	CELA1	ENSP00000481450	ENSP00000293636	Pancreatic alpha-amylase; Amylase, alpha 2A	Chymotrypsin-like elastase family member 1; Acts upon elastin	0.565
AMY2A	CPA1	ENSP00000481450	ENSP00000011292	Pancreatic alpha-amylase; Amylase, alpha 2A	Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C- terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro; Belongs to the peptidase M14 family	0.560
AMY2A	CPA5	ENSP00000481450	ENSP00000420237	Pancreatic alpha-amylase; Amylase, alpha 2A	M14 carboxypeptidases; Belongs to the peptidase M14 family	0.416
AMY2A	CPB1	ENSP00000481450	ENSP00000417222	Pancreatic alpha-amylase; Amylase, alpha 2A	M14 carboxypeptidases; Belongs to the peptidase M14 family	0.566
AMY2A	SCT	ENSP00000481450	ENSP00000176195	Pancreatic alpha-amylase; Amylase, alpha 2A	Secretin; Stimulates formation of NaHCO(3)-rich pancreatic juice and secretion of NaHCO(3)-rich bile and inhibits HCl production by the stomach; Endogenous ligands	0.448
BLZF1	CELA1	ENSP00000356782	ENSP00000293636	Golgin-45; Required for normal Golgi structure and for protein transport from the endoplasmic reticulum (ER) through the Golgi apparatus to the cell surface	Chymotrypsin-like elastase family member 1; Acts upon elastin	0.660
CELA1	A2M	ENSP00000293636	ENSP00000323929	Chymotrypsin-like elastase family member 1; Acts upon elastin	Alpha-2-macroglobulin; Is able to inhibit all four classes of proteinases by a unique ’trapping’ mechanism. This protein has a peptide stretch, called the ’bait region’ which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the c [...]	0.602
CELA1	AMY2A	ENSP00000293636	ENSP00000481450	Chymotrypsin-like elastase family member 1; Acts upon elastin	Pancreatic alpha-amylase; Amylase, alpha 2A	0.565
CELA1	BLZF1	ENSP00000293636	ENSP00000356782	Chymotrypsin-like elastase family member 1; Acts upon elastin	Golgin-45; Required for normal Golgi structure and for protein transport from the endoplasmic reticulum (ER) through the Golgi apparatus to the cell surface	0.660
CELA1	CPA1	ENSP00000293636	ENSP00000011292	Chymotrypsin-like elastase family member 1; Acts upon elastin	Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C- terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro; Belongs to the peptidase M14 family	0.716
CELA1	CPA5	ENSP00000293636	ENSP00000420237	Chymotrypsin-like elastase family member 1; Acts upon elastin	M14 carboxypeptidases; Belongs to the peptidase M14 family	0.546
CELA1	CPA6	ENSP00000293636	ENSP00000297770	Chymotrypsin-like elastase family member 1; Acts upon elastin	Carboxypeptidase A6; May be involved in the proteolytic inactivation of enkephalins and neurotensin in some brain areas. May convert inactive angiotensin I into the biologically active angiotensin II. Releases a C-terminal amino acid, with preference for large hydrophobic C-terminal amino acids and shows only very weak activity toward small amino acids and histidine; M14 carboxypeptidases	0.589
CELA1	CPB1	ENSP00000293636	ENSP00000417222	Chymotrypsin-like elastase family member 1; Acts upon elastin	M14 carboxypeptidases; Belongs to the peptidase M14 family	0.557
CELA1	SCT	ENSP00000293636	ENSP00000176195	Chymotrypsin-like elastase family member 1; Acts upon elastin	Secretin; Stimulates formation of NaHCO(3)-rich pancreatic juice and secretion of NaHCO(3)-rich bile and inhibits HCl production by the stomach; Endogenous ligands	0.645
CELA1	SERPINA1	ENSP00000293636	ENSP00000416066	Chymotrypsin-like elastase family member 1; Acts upon elastin	Alpha-1-antitrypsin; Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin; Belongs to the serpin family	0.682
CELA1	SPINK1	ENSP00000293636	ENSP00000296695	Chymotrypsin-like elastase family member 1; Acts upon elastin	Serine protease inhibitor Kazal-type 1; Serine protease inhibitor which exhibits anti-trypsin activity. In the pancreas, protects against trypsin-catalyzed premature activation of zymogens (By similarity); Serine peptidase inhibitors, Kazal type	0.572
CPA1	AMY2A	ENSP00000011292	ENSP00000481450	Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C- terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro; Belongs to the peptidase M14 family	Pancreatic alpha-amylase; Amylase, alpha 2A	0.560
CPA1	CELA1	ENSP00000011292	ENSP00000293636	Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C- terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro; Belongs to the peptidase M14 family	Chymotrypsin-like elastase family member 1; Acts upon elastin	0.716

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