• Version:
  • 11.0 [archived version]
STRINGSTRING
UBXN10 UBXN10 OR10G6 OR10G6 EPS8L1 EPS8L1 TRIM28 TRIM28 ZNF613 ZNF613 ADRA1D ADRA1D ZRANB3 ZRANB3 GNG10 GNG10 TMEM102 TMEM102 EXTL2 EXTL2 GIMAP8 GIMAP8
"ZNF613" - Zinc finger protein 613 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ZNF613Zinc finger protein 613; May be involved in transcriptional regulation; Zinc fingers C2H2-type (617 aa)    
Predicted Functional Partners:
TRIM28
Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] (835 aa)
     
    0.903
TMEM102
Transmembrane protein 102; Selectively involved in CSF2 deprivation-induced apoptosis via a mitochondria-dependent pathway (508 aa)
           
  0.717
GIMAP8
GTPase IMAP family member 8; Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections; GTPases, IMAP (665 aa)
           
  0.555
OR10G6
Olfactory receptor 10G6; Odorant receptor; Olfactory receptors, family 10 (332 aa)
           
  0.543
GNG10
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction. Interacts with beta-1 and beta-2, but not with beta-3 (68 aa)
           
  0.529
EXTL2
Exostosin-like 2; Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N- acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains (330 aa)
           
  0.515
ADRA1D
Alpha-1D adrenergic receptor; This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium; Adrenoceptors (572 aa)
       
 
  0.508
UBXN10
UBX domain-containing protein 10; VCP/p97-binding protein required for ciliogenesis. Acts as a tethering factor that facilitates recruitment of VCP/p97 to the intraflagellar transport complex B (IFT-B) in cilia. UBX domain-containing proteins act as tethering factors for VCP/p97 and may specify substrate specificity of VCP/p97 (280 aa)
           
  0.487
ZRANB3
DNA annealing helicase and endonuclease ZRANB3; DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events. Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3’-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase. [...] (1079 aa)
     
 
  0.449
EPS8L1
Epidermal growth factor receptor kinase substrate 8-like protein 1; Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton; Belongs to the EPS8 family (723 aa)
       
 
  0.438
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
Server load: low (0%) [HD]