IZUMO2 protein (human) - STRING database

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IZUMO2

Izumo sperm-egg fusion protein 2; IZUMO family member 2 (221 aa)

Predicted Functional Partners:

CD9

0.910

IZUMO4

0.895

IZUMO3

0.857

ADAM32

0.689

ADAM2

0.672

IZUMO1

0.663

OR4K14

0.559

OR4N5

0.534

C11orf80

0.480

ISOC2

0.467

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAM2	CD9	ENSP00000265708	ENSP00000371958	Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein; ADAM metallopeptidase domain containing	CD9 antigen; Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion; Belongs to the tetraspanin (TM4SF) family	0.695
ADAM2	IZUMO1	ENSP00000265708	ENSP00000327786	Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein; ADAM metallopeptidase domain containing	Izumo sperm-egg fusion protein 1; Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1-IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane ’fusogen’	0.668
ADAM2	IZUMO2	ENSP00000265708	ENSP00000293405	Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein; ADAM metallopeptidase domain containing	Izumo sperm-egg fusion protein 2; IZUMO family member 2	0.672
ADAM2	IZUMO3	ENSP00000265708	ENSP00000474246	Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein; ADAM metallopeptidase domain containing	Izumo sperm-egg fusion protein 3; IZUMO family member 3	0.676
ADAM2	IZUMO4	ENSP00000265708	ENSP00000378712	Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein; ADAM metallopeptidase domain containing	Izumo sperm-egg fusion protein 4; IZUMO family member 4; Belongs to the Izumo family	0.536
ADAM32	IZUMO2	ENSP00000369238	ENSP00000293405	Disintegrin and metalloproteinase domain-containing protein 32; May play a role in sperm development and fertilization This is a non-catalytic metalloprotease-like protein; ADAM metallopeptidase domain containing	Izumo sperm-egg fusion protein 2; IZUMO family member 2	0.689
ADAM32	IZUMO3	ENSP00000369238	ENSP00000474246	Disintegrin and metalloproteinase domain-containing protein 32; May play a role in sperm development and fertilization This is a non-catalytic metalloprotease-like protein; ADAM metallopeptidase domain containing	Izumo sperm-egg fusion protein 3; IZUMO family member 3	0.721
ADAM32	IZUMO4	ENSP00000369238	ENSP00000378712	Disintegrin and metalloproteinase domain-containing protein 32; May play a role in sperm development and fertilization This is a non-catalytic metalloprotease-like protein; ADAM metallopeptidase domain containing	Izumo sperm-egg fusion protein 4; IZUMO family member 4; Belongs to the Izumo family	0.588
C11orf80	IZUMO2	ENSP00000354227	ENSP00000293405	Type 2 DNA topoisomerase 6 subunit B-like; Isoform 3- Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles	Izumo sperm-egg fusion protein 2; IZUMO family member 2	0.480
C11orf80	OR4K14	ENSP00000354227	ENSP00000305011	Type 2 DNA topoisomerase 6 subunit B-like; Isoform 3- Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles	Olfactory receptor 4K14; Odorant receptor; Olfactory receptors, family 4	0.726
C11orf80	OR4N5	ENSP00000354227	ENSP00000332110	Type 2 DNA topoisomerase 6 subunit B-like; Isoform 3- Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles	Olfactory receptor 4N5; Odorant receptor; Olfactory receptors, family 4	0.712
CD9	ADAM2	ENSP00000371958	ENSP00000265708	CD9 antigen; Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion; Belongs to the tetraspanin (TM4SF) family	Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein; ADAM metallopeptidase domain containing	0.695
CD9	IZUMO1	ENSP00000371958	ENSP00000327786	CD9 antigen; Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion; Belongs to the tetraspanin (TM4SF) family	Izumo sperm-egg fusion protein 1; Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1-IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane ’fusogen’	0.966
CD9	IZUMO2	ENSP00000371958	ENSP00000293405	CD9 antigen; Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion; Belongs to the tetraspanin (TM4SF) family	Izumo sperm-egg fusion protein 2; IZUMO family member 2	0.910
CD9	IZUMO3	ENSP00000371958	ENSP00000474246	CD9 antigen; Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion; Belongs to the tetraspanin (TM4SF) family	Izumo sperm-egg fusion protein 3; IZUMO family member 3	0.921
CD9	IZUMO4	ENSP00000371958	ENSP00000378712	CD9 antigen; Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion; Belongs to the tetraspanin (TM4SF) family	Izumo sperm-egg fusion protein 4; IZUMO family member 4; Belongs to the Izumo family	0.942
ISOC2	IZUMO1	ENSP00000085068	ENSP00000327786	Isochorismatase domain containing 2	Izumo sperm-egg fusion protein 1; Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1-IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane ’fusogen’	0.561
ISOC2	IZUMO2	ENSP00000085068	ENSP00000293405	Isochorismatase domain containing 2	Izumo sperm-egg fusion protein 2; IZUMO family member 2	0.467
ISOC2	IZUMO3	ENSP00000085068	ENSP00000474246	Isochorismatase domain containing 2	Izumo sperm-egg fusion protein 3; IZUMO family member 3	0.633
ISOC2	IZUMO4	ENSP00000085068	ENSP00000378712	Isochorismatase domain containing 2	Izumo sperm-egg fusion protein 4; IZUMO family member 4; Belongs to the Izumo family	0.427

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