ZNF382 protein (human) - STRING database

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ZNF382

Zinc finger protein 382; Functions as a sequence-specific transcriptional repressor; Belongs to the krueppel C2H2-type zinc-finger protein family (550 aa)

Predicted Functional Partners:

TRIM28

0.983

LMOD1

0.641

MAGEC2

0.569

GIPC2

0.477

HSPA4L

0.428

GNA14

0.424

CBX1

0.405

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBX1	TRIM28	ENSP00000377060	ENSP00000253024	Chromobox protein homolog 1; Component of heterochromatin. Recognizes and binds histone H3 tails methylated at ’Lys-9’, leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane; Chromobox family	Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...]	0.790
CBX1	ZNF382	ENSP00000377060	ENSP00000292928	Chromobox protein homolog 1; Component of heterochromatin. Recognizes and binds histone H3 tails methylated at ’Lys-9’, leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane; Chromobox family	Zinc finger protein 382; Functions as a sequence-specific transcriptional repressor; Belongs to the krueppel C2H2-type zinc-finger protein family	0.405
GIPC2	GNA14	ENSP00000359795	ENSP00000365807	PDZ domain-containing protein GIPC2; GIPC PDZ domain containing family member 2; Belongs to the GIPC family	Guanine nucleotide-binding protein subunit alpha-14; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; G protein subunits alpha, group q	0.466
GIPC2	HSPA4L	ENSP00000359795	ENSP00000296464	PDZ domain-containing protein GIPC2; GIPC PDZ domain containing family member 2; Belongs to the GIPC family	Heat shock 70 kDa protein 4L; Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase; Belongs to the heat shock protein 70 family	0.414
GIPC2	ZNF382	ENSP00000359795	ENSP00000292928	PDZ domain-containing protein GIPC2; GIPC PDZ domain containing family member 2; Belongs to the GIPC family	Zinc finger protein 382; Functions as a sequence-specific transcriptional repressor; Belongs to the krueppel C2H2-type zinc-finger protein family	0.477
GNA14	GIPC2	ENSP00000365807	ENSP00000359795	Guanine nucleotide-binding protein subunit alpha-14; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; G protein subunits alpha, group q	PDZ domain-containing protein GIPC2; GIPC PDZ domain containing family member 2; Belongs to the GIPC family	0.466
GNA14	ZNF382	ENSP00000365807	ENSP00000292928	Guanine nucleotide-binding protein subunit alpha-14; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; G protein subunits alpha, group q	Zinc finger protein 382; Functions as a sequence-specific transcriptional repressor; Belongs to the krueppel C2H2-type zinc-finger protein family	0.424
HSPA4L	GIPC2	ENSP00000296464	ENSP00000359795	Heat shock 70 kDa protein 4L; Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase; Belongs to the heat shock protein 70 family	PDZ domain-containing protein GIPC2; GIPC PDZ domain containing family member 2; Belongs to the GIPC family	0.414
HSPA4L	ZNF382	ENSP00000296464	ENSP00000292928	Heat shock 70 kDa protein 4L; Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase; Belongs to the heat shock protein 70 family	Zinc finger protein 382; Functions as a sequence-specific transcriptional repressor; Belongs to the krueppel C2H2-type zinc-finger protein family	0.428
LMOD1	ZNF382	ENSP00000356257	ENSP00000292928	Leiomodin-1; Mediates nucleation of actin filaments; Belongs to the tropomodulin family	Zinc finger protein 382; Functions as a sequence-specific transcriptional repressor; Belongs to the krueppel C2H2-type zinc-finger protein family	0.641
MAGEC2	TRIM28	ENSP00000354660	ENSP00000253024	Melanoma-associated antigen C2; Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3-substrate complex; MAGE family	Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...]	0.774
MAGEC2	ZNF382	ENSP00000354660	ENSP00000292928	Melanoma-associated antigen C2; Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3-substrate complex; MAGE family	Zinc finger protein 382; Functions as a sequence-specific transcriptional repressor; Belongs to the krueppel C2H2-type zinc-finger protein family	0.569
TRIM28	CBX1	ENSP00000253024	ENSP00000377060	Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...]	Chromobox protein homolog 1; Component of heterochromatin. Recognizes and binds histone H3 tails methylated at ’Lys-9’, leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane; Chromobox family	0.790
TRIM28	MAGEC2	ENSP00000253024	ENSP00000354660	Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...]	Melanoma-associated antigen C2; Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3-substrate complex; MAGE family	0.774
TRIM28	ZNF382	ENSP00000253024	ENSP00000292928	Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...]	Zinc finger protein 382; Functions as a sequence-specific transcriptional repressor; Belongs to the krueppel C2H2-type zinc-finger protein family	0.983
ZNF382	CBX1	ENSP00000292928	ENSP00000377060	Zinc finger protein 382; Functions as a sequence-specific transcriptional repressor; Belongs to the krueppel C2H2-type zinc-finger protein family	Chromobox protein homolog 1; Component of heterochromatin. Recognizes and binds histone H3 tails methylated at ’Lys-9’, leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane; Chromobox family	0.405
ZNF382	GIPC2	ENSP00000292928	ENSP00000359795	Zinc finger protein 382; Functions as a sequence-specific transcriptional repressor; Belongs to the krueppel C2H2-type zinc-finger protein family	PDZ domain-containing protein GIPC2; GIPC PDZ domain containing family member 2; Belongs to the GIPC family	0.477
ZNF382	GNA14	ENSP00000292928	ENSP00000365807	Zinc finger protein 382; Functions as a sequence-specific transcriptional repressor; Belongs to the krueppel C2H2-type zinc-finger protein family	Guanine nucleotide-binding protein subunit alpha-14; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; G protein subunits alpha, group q	0.424
ZNF382	HSPA4L	ENSP00000292928	ENSP00000296464	Zinc finger protein 382; Functions as a sequence-specific transcriptional repressor; Belongs to the krueppel C2H2-type zinc-finger protein family	Heat shock 70 kDa protein 4L; Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase; Belongs to the heat shock protein 70 family	0.428
ZNF382	LMOD1	ENSP00000292928	ENSP00000356257	Zinc finger protein 382; Functions as a sequence-specific transcriptional repressor; Belongs to the krueppel C2H2-type zinc-finger protein family	Leiomodin-1; Mediates nucleation of actin filaments; Belongs to the tropomodulin family	0.641

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