THAP8 protein (human) - STRING database

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THAP8

THAP domain containing 8 (274 aa)

Predicted Functional Partners:

THAP6

0.669

ANKRD18B

0.669

THAP10

0.669

THAP11

0.609

THAP9

0.583

ANKRD32

0.553

PRKRIR

0.545

C9orf16

0.534

ANO7

0.533

PRMT7

0.513

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKRD18B	ANKRD32	ENSP00000290943	ENSP00000265140	Ankyrin repeat domain-containing protein 18B; Ankyrin repeat domain containing	SMC5-SMC6 complex localization factor protein 1; Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance. The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication- coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks. Promotes the recruitment of SLF2 and the SMC5-SMC6 complex to DNA lesions	0.502
ANKRD18B	ANO7	ENSP00000290943	ENSP00000274979	Ankyrin repeat domain-containing protein 18B; Ankyrin repeat domain containing	Anoctamin-7; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium- activated chloride channel (CaCC) activity. May play a role in cell-cell interactions; Anoctamins	0.422
ANKRD18B	THAP8	ENSP00000290943	ENSP00000292894	Ankyrin repeat domain-containing protein 18B; Ankyrin repeat domain containing	THAP domain containing 8	0.669
ANKRD32	ANKRD18B	ENSP00000265140	ENSP00000290943	SMC5-SMC6 complex localization factor protein 1; Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance. The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication- coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks. Promotes the recruitment of SLF2 and the SMC5-SMC6 complex to DNA lesions	Ankyrin repeat domain-containing protein 18B; Ankyrin repeat domain containing	0.502
ANKRD32	THAP8	ENSP00000265140	ENSP00000292894	SMC5-SMC6 complex localization factor protein 1; Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance. The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication- coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks. Promotes the recruitment of SLF2 and the SMC5-SMC6 complex to DNA lesions	THAP domain containing 8	0.553
ANO7	ANKRD18B	ENSP00000274979	ENSP00000290943	Anoctamin-7; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium- activated chloride channel (CaCC) activity. May play a role in cell-cell interactions; Anoctamins	Ankyrin repeat domain-containing protein 18B; Ankyrin repeat domain containing	0.422
ANO7	THAP8	ENSP00000274979	ENSP00000292894	Anoctamin-7; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium- activated chloride channel (CaCC) activity. May play a role in cell-cell interactions; Anoctamins	THAP domain containing 8	0.533
C9orf16	THAP8	ENSP00000362085	ENSP00000292894	UPF0184 protein C9orf16; Chromosome 9 open reading frame 16	THAP domain containing 8	0.534
PRKRIR	THAP10	ENSP00000260045	ENSP00000249861	52 kDa repressor of the inhibitor of the protein kinase; Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR- inhibitory function of DNAJC3, resulting in restoration of kinase activity and suppression of cell growth	THAP domain containing 10	0.441
PRKRIR	THAP11	ENSP00000260045	ENSP00000304689	52 kDa repressor of the inhibitor of the protein kinase; Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR- inhibitory function of DNAJC3, resulting in restoration of kinase activity and suppression of cell growth	THAP domain-containing protein 11; Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity); THAP domain containing	0.804
PRKRIR	THAP6	ENSP00000260045	ENSP00000309007	52 kDa repressor of the inhibitor of the protein kinase; Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR- inhibitory function of DNAJC3, resulting in restoration of kinase activity and suppression of cell growth	THAP domain containing 6	0.440
PRKRIR	THAP8	ENSP00000260045	ENSP00000292894	52 kDa repressor of the inhibitor of the protein kinase; Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR- inhibitory function of DNAJC3, resulting in restoration of kinase activity and suppression of cell growth	THAP domain containing 8	0.545
PRKRIR	THAP9	ENSP00000260045	ENSP00000305533	52 kDa repressor of the inhibitor of the protein kinase; Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR- inhibitory function of DNAJC3, resulting in restoration of kinase activity and suppression of cell growth	DNA transposase THAP9; Active transposase that specifically recognizes the bipartite 5’-TXXGGGX(A/T)-3’ consensus motif and mediates transposition; THAP domain containing	0.588
PRMT7	THAP8	ENSP00000343103	ENSP00000292894	Protein arginine N-methyltransferase 7; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 ’Arg-3’ to form H4R3me2s. Plays a role in gene imprinting by being [...]	THAP domain containing 8	0.513
THAP10	PRKRIR	ENSP00000249861	ENSP00000260045	THAP domain containing 10	52 kDa repressor of the inhibitor of the protein kinase; Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR- inhibitory function of DNAJC3, resulting in restoration of kinase activity and suppression of cell growth	0.441
THAP10	THAP11	ENSP00000249861	ENSP00000304689	THAP domain containing 10	THAP domain-containing protein 11; Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity); THAP domain containing	0.446
THAP10	THAP6	ENSP00000249861	ENSP00000309007	THAP domain containing 10	THAP domain containing 6	0.559
THAP10	THAP8	ENSP00000249861	ENSP00000292894	THAP domain containing 10	THAP domain containing 8	0.669
THAP10	THAP9	ENSP00000249861	ENSP00000305533	THAP domain containing 10	DNA transposase THAP9; Active transposase that specifically recognizes the bipartite 5’-TXXGGGX(A/T)-3’ consensus motif and mediates transposition; THAP domain containing	0.543
THAP11	PRKRIR	ENSP00000304689	ENSP00000260045	THAP domain-containing protein 11; Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity); THAP domain containing	52 kDa repressor of the inhibitor of the protein kinase; Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR- inhibitory function of DNAJC3, resulting in restoration of kinase activity and suppression of cell growth	0.804

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