node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKFN1 | C5orf45 | ENSP00000321627 | ENSP00000292586 | Ankyrin repeat and fibronectin type III domain containing 1 | MRN complex-interacting protein; Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex. Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair | 0.556 |
ANKFN1 | CCDC180 | ENSP00000321627 | ENSP00000434727 | Ankyrin repeat and fibronectin type III domain containing 1 | Coiled-coil domain containing 180 | 0.429 |
ANKFN1 | RNF217 | ENSP00000321627 | ENSP00000428698 | Ankyrin repeat and fibronectin type III domain containing 1 | Probable E3 ubiquitin-protein ligase RNF217; E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes in the form of a thioester and then directly transfers the ubiquitin to targeted substrates; Belongs to the RBR family. RNF217 subfamily | 0.459 |
ANKFN1 | SCRN3 | ENSP00000321627 | ENSP00000272732 | Ankyrin repeat and fibronectin type III domain containing 1 | Secernin-3; Secernin 3 | 0.446 |
ANKFN1 | TMEM132B | ENSP00000321627 | ENSP00000299308 | Ankyrin repeat and fibronectin type III domain containing 1 | Transmembrane protein 132B; Belongs to the TMEM132 family | 0.441 |
ATMIN | C5orf45 | ENSP00000299575 | ENSP00000292586 | ATM interactor; Transcription factor. Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage. Involved in regulating the activity of ATM in the absence of DNA damage. May play a role in stabilizing ATM. Binds to the DYNLL1 promoter and activates its transcription; Zinc fingers C2H2-type | MRN complex-interacting protein; Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex. Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair | 0.440 |
C5orf45 | ANKFN1 | ENSP00000292586 | ENSP00000321627 | MRN complex-interacting protein; Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex. Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair | Ankyrin repeat and fibronectin type III domain containing 1 | 0.556 |
C5orf45 | ATMIN | ENSP00000292586 | ENSP00000299575 | MRN complex-interacting protein; Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex. Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair | ATM interactor; Transcription factor. Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage. Involved in regulating the activity of ATM in the absence of DNA damage. May play a role in stabilizing ATM. Binds to the DYNLL1 promoter and activates its transcription; Zinc fingers C2H2-type | 0.440 |
C5orf45 | CCDC180 | ENSP00000292586 | ENSP00000434727 | MRN complex-interacting protein; Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex. Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair | Coiled-coil domain containing 180 | 0.571 |
C5orf45 | FLJ22184 | ENSP00000292586 | ENSP00000482374 | MRN complex-interacting protein; Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex. Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair | Proline-rich protein 36; Putative uncharacterized protein FLJ22184 | 0.628 |
C5orf45 | LHFPL3 | ENSP00000292586 | ENSP00000393128 | MRN complex-interacting protein; Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex. Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair | LHFPL tetraspan subfamily member 3 | 0.479 |
C5orf45 | LRP5 | ENSP00000292586 | ENSP00000294304 | MRN complex-interacting protein; Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex. Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair | Low-density lipoprotein receptor-related protein 5; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. Plays a role in norrin (NDP) signal transduction. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN [...] | 0.525 |
C5orf45 | LRP5L | ENSP00000292586 | ENSP00000482378 | MRN complex-interacting protein; Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex. Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair | Low-density lipoprotein receptor-related protein 5-like protein; LDL receptor related protein 5 like | 0.525 |
C5orf45 | RNF217 | ENSP00000292586 | ENSP00000428698 | MRN complex-interacting protein; Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex. Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair | Probable E3 ubiquitin-protein ligase RNF217; E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes in the form of a thioester and then directly transfers the ubiquitin to targeted substrates; Belongs to the RBR family. RNF217 subfamily | 0.576 |
C5orf45 | SCRN3 | ENSP00000292586 | ENSP00000272732 | MRN complex-interacting protein; Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex. Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair | Secernin-3; Secernin 3 | 0.558 |
C5orf45 | TMEM132B | ENSP00000292586 | ENSP00000299308 | MRN complex-interacting protein; Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex. Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair | Transmembrane protein 132B; Belongs to the TMEM132 family | 0.557 |
CCDC180 | ANKFN1 | ENSP00000434727 | ENSP00000321627 | Coiled-coil domain containing 180 | Ankyrin repeat and fibronectin type III domain containing 1 | 0.429 |
CCDC180 | C5orf45 | ENSP00000434727 | ENSP00000292586 | Coiled-coil domain containing 180 | MRN complex-interacting protein; Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex. Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair | 0.571 |
CCDC180 | FLJ22184 | ENSP00000434727 | ENSP00000482374 | Coiled-coil domain containing 180 | Proline-rich protein 36; Putative uncharacterized protein FLJ22184 | 0.537 |
CCDC180 | RNF217 | ENSP00000434727 | ENSP00000428698 | Coiled-coil domain containing 180 | Probable E3 ubiquitin-protein ligase RNF217; E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes in the form of a thioester and then directly transfers the ubiquitin to targeted substrates; Belongs to the RBR family. RNF217 subfamily | 0.470 |