• Version:
  • 11.0 [archived version]
STRINGSTRING
LRP5L LRP5L LRP5 LRP5 FLJ22184 FLJ22184 LHFPL3 LHFPL3 C5orf45 C5orf45 CCDC180 CCDC180 ATMIN ATMIN ANKFN1 ANKFN1 RNF217 RNF217 TMEM132B TMEM132B SCRN3 SCRN3
"C5orf45" - MRN complex-interacting protein in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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C5orf45MRN complex-interacting protein; Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex. Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair (343 aa)    
Predicted Functional Partners:
FLJ22184
Proline-rich protein 36; Putative uncharacterized protein FLJ22184 (1346 aa)
     
        0.628
RNF217
Probable E3 ubiquitin-protein ligase RNF217; E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes in the form of a thioester and then directly transfers the ubiquitin to targeted substrates; Belongs to the RBR family. RNF217 subfamily (542 aa)
           
  0.576
CCDC180
Coiled-coil domain containing 180 (1701 aa)
           
  0.571
SCRN3
Secernin-3; Secernin 3 (424 aa)
           
  0.558
TMEM132B
Transmembrane protein 132B; Belongs to the TMEM132 family (1078 aa)
           
  0.557
ANKFN1
Ankyrin repeat and fibronectin type III domain containing 1 (763 aa)
           
  0.556
LRP5L
Low-density lipoprotein receptor-related protein 5-like protein; LDL receptor related protein 5 like (252 aa)
     
        0.525
LRP5
Low-density lipoprotein receptor-related protein 5; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. Plays a role in norrin (NDP) signal transduction. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN [...] (1615 aa)
     
        0.525
LHFPL3
LHFPL tetraspan subfamily member 3 (222 aa)
           
  0.479
ATMIN
ATM interactor; Transcription factor. Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage. Involved in regulating the activity of ATM in the absence of DNA damage. May play a role in stabilizing ATM. Binds to the DYNLL1 promoter and activates its transcription; Zinc fingers C2H2-type (823 aa)
           
  0.440
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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