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  • 11.0 [archived version]
STRINGSTRING
LYPD3 LYPD3 ETHE1 ETHE1 C19orf68 C19orf68 ZNF575 ZNF575 TEX101 TEX101 PHLDB3 PHLDB3 ZNF324 ZNF324 ZFP62 ZFP62 SHROOM1 SHROOM1 EMC6 EMC6 UBXN8 UBXN8
"PHLDB3" - Pleckstrin homology like domain family B member 3 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PHLDB3Pleckstrin homology like domain family B member 3 (640 aa)    
Predicted Functional Partners:
ZNF575
Zinc finger protein 575; May be involved in transcriptional regulation; Zinc fingers C2H2-type (245 aa)
           
  0.828
TEX101
Testis-expressed protein 101; Plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct (By similarity). May play a role in signal transduction and promote protein tyrosine phosphorylation (By similarity); LY6/PLAUR domain containing (267 aa)
           
  0.776
ETHE1
Persulfide dioxygenase ETHE1, mitochondrial; Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H(2)S) is first oxidized by SQRDL, giving rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H(2)S levels that have toxic [...] (254 aa)
           
  0.768
LYPD3
Ly6/PLAUR domain-containing protein 3; Supports cell migration. May be involved in urothelial cell-matrix interactions. May be involved in tumor progression; LY6/PLAUR domain containing (346 aa)
     
   
  0.736
ZNF324
Zinc finger protein 324A; May be involved in transcriptional regulation. May be involved in regulation of cell proliferation; Belongs to the krueppel C2H2-type zinc-finger protein family (553 aa)
           
  0.589
C19orf68
Uncharacterized protein ZSWIM9; Chromosome 19 open reading frame 68 (920 aa)
           
  0.563
UBXN8
UBX domain-containing protein 8; Involved in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins, possibly by tethering VCP to the endoplasmic reticulum membrane. May play a role in reproduction; UBX domain containing (270 aa)
           
  0.525
EMC6
ER membrane protein complex subunit 6; Belongs to the EMC6 family (110 aa)
           
  0.522
SHROOM1
Protein Shroom1; May be involved in the assembly of microtubule arrays during cell elongation (852 aa)
           
  0.522
ZFP62
Zinc finger protein 62 homolog; May play a role in differentiating skeletal muscle; Zinc fingers C2H2-type (900 aa)
           
  0.520
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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