NLRP8 protein (human) - STRING database

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NLRP8

NACHT, LRR and PYD domains-containing protein 8; Involved in inflammation; NLR family (1048 aa)

Predicted Functional Partners:

TAF8

0.860

OR10P1

0.654

MEFV

0.641

IFNGR2

0.482

CASP1

0.469

ZSCAN5B

0.418

ZSCAN5A

0.410

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP1	MEFV	ENSP00000433138	ENSP00000219596	Caspase-1; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of MB21D1/cGAS, rendering it inactive; Belongs to the peptidase C14A family	Pyrin; Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18- mediated inflammation. However, i [...]	0.967
CASP1	NLRP8	ENSP00000433138	ENSP00000291971	Caspase-1; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of MB21D1/cGAS, rendering it inactive; Belongs to the peptidase C14A family	NACHT, LRR and PYD domains-containing protein 8; Involved in inflammation; NLR family	0.469
IFNGR2	NLRP8	ENSP00000290219	ENSP00000291971	Interferon gamma receptor 2; Associates with IFNGR1 to form a receptor for the cytokine interferon gamma (IFNG). Ligand binding stimulates activation of the JAK/STAT signaling pathway. Required for signal transduction in contrast to other receptor subunit responsible for ligand binding; Fibronectin type III domain containing	NACHT, LRR and PYD domains-containing protein 8; Involved in inflammation; NLR family	0.482
MEFV	CASP1	ENSP00000219596	ENSP00000433138	Pyrin; Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18- mediated inflammation. However, i [...]	Caspase-1; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of MB21D1/cGAS, rendering it inactive; Belongs to the peptidase C14A family	0.967
MEFV	NLRP8	ENSP00000219596	ENSP00000291971	Pyrin; Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18- mediated inflammation. However, i [...]	NACHT, LRR and PYD domains-containing protein 8; Involved in inflammation; NLR family	0.641
NLRP8	CASP1	ENSP00000291971	ENSP00000433138	NACHT, LRR and PYD domains-containing protein 8; Involved in inflammation; NLR family	Caspase-1; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of MB21D1/cGAS, rendering it inactive; Belongs to the peptidase C14A family	0.469
NLRP8	IFNGR2	ENSP00000291971	ENSP00000290219	NACHT, LRR and PYD domains-containing protein 8; Involved in inflammation; NLR family	Interferon gamma receptor 2; Associates with IFNGR1 to form a receptor for the cytokine interferon gamma (IFNG). Ligand binding stimulates activation of the JAK/STAT signaling pathway. Required for signal transduction in contrast to other receptor subunit responsible for ligand binding; Fibronectin type III domain containing	0.482
NLRP8	MEFV	ENSP00000291971	ENSP00000219596	NACHT, LRR and PYD domains-containing protein 8; Involved in inflammation; NLR family	Pyrin; Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18- mediated inflammation. However, i [...]	0.641
NLRP8	OR10P1	ENSP00000291971	ENSP00000308082	NACHT, LRR and PYD domains-containing protein 8; Involved in inflammation; NLR family	Olfactory receptor 10P1; Odorant receptor; Olfactory receptors, family 10	0.654
NLRP8	TAF8	ENSP00000291971	ENSP00000362068	NACHT, LRR and PYD domains-containing protein 8; Involved in inflammation; NLR family	Transcription initiation factor TFIID subunit 8; Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. Mediates both basal and activator-dependent transcription. Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts. Required for the integration of TAF10 in the TAF complex. May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (By similarity); Be [...]	0.860
NLRP8	ZSCAN5A	ENSP00000291971	ENSP00000375593	NACHT, LRR and PYD domains-containing protein 8; Involved in inflammation; NLR family	Zinc finger and SCAN domain-containing protein 5A; May be involved in transcriptional regulation; SCAN domain containing	0.410
NLRP8	ZSCAN5B	ENSP00000291971	ENSP00000466072	NACHT, LRR and PYD domains-containing protein 8; Involved in inflammation; NLR family	Zinc finger and SCAN domain-containing protein 5B; May be involved in transcriptional regulation; SCAN domain containing	0.418
OR10P1	NLRP8	ENSP00000308082	ENSP00000291971	Olfactory receptor 10P1; Odorant receptor; Olfactory receptors, family 10	NACHT, LRR and PYD domains-containing protein 8; Involved in inflammation; NLR family	0.654
TAF8	NLRP8	ENSP00000362068	ENSP00000291971	Transcription initiation factor TFIID subunit 8; Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. Mediates both basal and activator-dependent transcription. Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts. Required for the integration of TAF10 in the TAF complex. May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (By similarity); Be [...]	NACHT, LRR and PYD domains-containing protein 8; Involved in inflammation; NLR family	0.860
ZSCAN5A	NLRP8	ENSP00000375593	ENSP00000291971	Zinc finger and SCAN domain-containing protein 5A; May be involved in transcriptional regulation; SCAN domain containing	NACHT, LRR and PYD domains-containing protein 8; Involved in inflammation; NLR family	0.410
ZSCAN5B	NLRP8	ENSP00000466072	ENSP00000291971	Zinc finger and SCAN domain-containing protein 5B; May be involved in transcriptional regulation; SCAN domain containing	NACHT, LRR and PYD domains-containing protein 8; Involved in inflammation; NLR family	0.418

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