• Version:
  • 11.0 [archived version]
STRINGSTRING
IZUMO1 IZUMO1 CRISP1 CRISP1 RANBP17 RANBP17 FSCB FSCB TMEM190 TMEM190 PKDREJ PKDREJ ARMC4 ARMC4 SPAG6 SPAG6 MS4A8 MS4A8 ARMC3 ARMC3 WDR63 WDR63
"TMEM190" - Transmembrane protein 190 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TMEM190Transmembrane protein 190 (177 aa)    
Predicted Functional Partners:
FSCB
Fibrous sheath CABYR-binding protein; May be involved in the later stages of fibrous sheath biogenesis and spermatozoa capacitation. Inhibits ROPN1 and ROPN1L SUMOylation. Binds calcium (825 aa)
     
   
  0.707
WDR63
WD repeat-containing protein 63; WD repeat domain containing (891 aa)
           
  0.585
CRISP1
Cysteine-rich secretory protein 1; May have a role in sperm-egg fusion and maturation; Belongs to the CRISP family (249 aa)
           
  0.575
MS4A8
Membrane-spanning 4-domains subfamily A member 8; May be involved in signal transduction as a component of a multimeric receptor complex; Membrane spanning 4-domains (250 aa)
           
  0.571
ARMC3
Armadillo repeat containing 3 (872 aa)
           
  0.557
PKDREJ
Polycystic kidney disease and receptor for egg jelly-related protein; May have a central role in fertilization. May generate a Ca(2+) transporting channel directly involved in initiating the acrosome reaction of the sperm; Belongs to the polycystin family (2253 aa)
           
  0.541
ARMC4
Armadillo repeat-containing protein 4; Ciliary protein that may be involved in a late step of axonemal outer dynein arm assembly; Armadillo repeat containing (1044 aa)
           
  0.531
RANBP17
Ran-binding protein 17; May function as a nuclear transport receptor; Armadillo-like helical domain containing (1088 aa)
           
  0.519
IZUMO1
Izumo sperm-egg fusion protein 1; Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1-IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane ’fusogen’ (350 aa)
           
  0.482
SPAG6
Sperm-associated antigen 6; Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility; Armadillo repeat containing (509 aa)
     
   
  0.453
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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