node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARMC3 | ARMC4 | ENSP00000298032 | ENSP00000306410 | Armadillo repeat containing 3 | Armadillo repeat-containing protein 4; Ciliary protein that may be involved in a late step of axonemal outer dynein arm assembly; Armadillo repeat containing | 0.417 |
ARMC3 | SPAG6 | ENSP00000298032 | ENSP00000365811 | Armadillo repeat containing 3 | Sperm-associated antigen 6; Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility; Armadillo repeat containing | 0.483 |
ARMC3 | TMEM190 | ENSP00000298032 | ENSP00000291934 | Armadillo repeat containing 3 | Transmembrane protein 190 | 0.557 |
ARMC3 | WDR63 | ENSP00000298032 | ENSP00000294664 | Armadillo repeat containing 3 | WD repeat-containing protein 63; WD repeat domain containing | 0.716 |
ARMC4 | ARMC3 | ENSP00000306410 | ENSP00000298032 | Armadillo repeat-containing protein 4; Ciliary protein that may be involved in a late step of axonemal outer dynein arm assembly; Armadillo repeat containing | Armadillo repeat containing 3 | 0.417 |
ARMC4 | SPAG6 | ENSP00000306410 | ENSP00000365811 | Armadillo repeat-containing protein 4; Ciliary protein that may be involved in a late step of axonemal outer dynein arm assembly; Armadillo repeat containing | Sperm-associated antigen 6; Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility; Armadillo repeat containing | 0.486 |
ARMC4 | TMEM190 | ENSP00000306410 | ENSP00000291934 | Armadillo repeat-containing protein 4; Ciliary protein that may be involved in a late step of axonemal outer dynein arm assembly; Armadillo repeat containing | Transmembrane protein 190 | 0.531 |
ARMC4 | WDR63 | ENSP00000306410 | ENSP00000294664 | Armadillo repeat-containing protein 4; Ciliary protein that may be involved in a late step of axonemal outer dynein arm assembly; Armadillo repeat containing | WD repeat-containing protein 63; WD repeat domain containing | 0.456 |
CRISP1 | FSCB | ENSP00000338276 | ENSP00000344579 | Cysteine-rich secretory protein 1; May have a role in sperm-egg fusion and maturation; Belongs to the CRISP family | Fibrous sheath CABYR-binding protein; May be involved in the later stages of fibrous sheath biogenesis and spermatozoa capacitation. Inhibits ROPN1 and ROPN1L SUMOylation. Binds calcium | 0.411 |
CRISP1 | IZUMO1 | ENSP00000338276 | ENSP00000327786 | Cysteine-rich secretory protein 1; May have a role in sperm-egg fusion and maturation; Belongs to the CRISP family | Izumo sperm-egg fusion protein 1; Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1-IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane ’fusogen’ | 0.561 |
CRISP1 | TMEM190 | ENSP00000338276 | ENSP00000291934 | Cysteine-rich secretory protein 1; May have a role in sperm-egg fusion and maturation; Belongs to the CRISP family | Transmembrane protein 190 | 0.575 |
FSCB | CRISP1 | ENSP00000344579 | ENSP00000338276 | Fibrous sheath CABYR-binding protein; May be involved in the later stages of fibrous sheath biogenesis and spermatozoa capacitation. Inhibits ROPN1 and ROPN1L SUMOylation. Binds calcium | Cysteine-rich secretory protein 1; May have a role in sperm-egg fusion and maturation; Belongs to the CRISP family | 0.411 |
FSCB | TMEM190 | ENSP00000344579 | ENSP00000291934 | Fibrous sheath CABYR-binding protein; May be involved in the later stages of fibrous sheath biogenesis and spermatozoa capacitation. Inhibits ROPN1 and ROPN1L SUMOylation. Binds calcium | Transmembrane protein 190 | 0.707 |
IZUMO1 | CRISP1 | ENSP00000327786 | ENSP00000338276 | Izumo sperm-egg fusion protein 1; Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1-IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane ’fusogen’ | Cysteine-rich secretory protein 1; May have a role in sperm-egg fusion and maturation; Belongs to the CRISP family | 0.561 |
IZUMO1 | TMEM190 | ENSP00000327786 | ENSP00000291934 | Izumo sperm-egg fusion protein 1; Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1-IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane ’fusogen’ | Transmembrane protein 190 | 0.482 |
MS4A8 | TMEM190 | ENSP00000300226 | ENSP00000291934 | Membrane-spanning 4-domains subfamily A member 8; May be involved in signal transduction as a component of a multimeric receptor complex; Membrane spanning 4-domains | Transmembrane protein 190 | 0.571 |
MS4A8 | WDR63 | ENSP00000300226 | ENSP00000294664 | Membrane-spanning 4-domains subfamily A member 8; May be involved in signal transduction as a component of a multimeric receptor complex; Membrane spanning 4-domains | WD repeat-containing protein 63; WD repeat domain containing | 0.400 |
PKDREJ | SPAG6 | ENSP00000253255 | ENSP00000365811 | Polycystic kidney disease and receptor for egg jelly-related protein; May have a central role in fertilization. May generate a Ca(2+) transporting channel directly involved in initiating the acrosome reaction of the sperm; Belongs to the polycystin family | Sperm-associated antigen 6; Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility; Armadillo repeat containing | 0.517 |
PKDREJ | TMEM190 | ENSP00000253255 | ENSP00000291934 | Polycystic kidney disease and receptor for egg jelly-related protein; May have a central role in fertilization. May generate a Ca(2+) transporting channel directly involved in initiating the acrosome reaction of the sperm; Belongs to the polycystin family | Transmembrane protein 190 | 0.541 |
RANBP17 | TMEM190 | ENSP00000427975 | ENSP00000291934 | Ran-binding protein 17; May function as a nuclear transport receptor; Armadillo-like helical domain containing | Transmembrane protein 190 | 0.519 |