| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APPBP2 | HIPK4 | ENSP00000083182 | ENSP00000291823 | Amyloid protein-binding protein 2; May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface | Homeodomain-interacting protein kinase 4; Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential) | 0.730 |
| ATP5SL | HIPK4 | ENSP00000403910 | ENSP00000291823 | Distal membrane-arm assembly complex protein 2; Required for the assembly of the mitochondrial NADH-ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I; Belongs to the ATP synthase subunit s family | Homeodomain-interacting protein kinase 4; Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential) | 0.557 |
| ATP5SL | IRGQ | ENSP00000403910 | ENSP00000387535 | Distal membrane-arm assembly complex protein 2; Required for the assembly of the mitochondrial NADH-ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I; Belongs to the ATP synthase subunit s family | Immunity-related GTPase family Q protein; Immunity related GTPase Q; Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family | 0.582 |
| ATP5SL | TTC9B | ENSP00000403910 | ENSP00000311760 | Distal membrane-arm assembly complex protein 2; Required for the assembly of the mitochondrial NADH-ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I; Belongs to the ATP synthase subunit s family | Tetratricopeptide repeat domain containing | 0.621 |
| DCAF7 | HIPK4 | ENSP00000483236 | ENSP00000291823 | DDB1- and CUL4-associated factor 7; Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches (By similarity). Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in normal and disease skin development. May function as a substrate receptor for CUL4- DDB1 E3 ubiquitin-protein ligase complex; Belongs to the WD repeat DCAF7 family | Homeodomain-interacting protein kinase 4; Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential) | 0.684 |
| FGL1 | HIPK4 | ENSP00000381133 | ENSP00000291823 | Fibrinogen-like protein 1; Has hepatocyte mitogenic activity; Fibrinogen C domain containing | Homeodomain-interacting protein kinase 4; Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential) | 0.709 |
| FGL1 | ZNF146 | ENSP00000381133 | ENSP00000400391 | Fibrinogen-like protein 1; Has hepatocyte mitogenic activity; Fibrinogen C domain containing | Zinc finger protein 146; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.437 |
| HIPK4 | APPBP2 | ENSP00000291823 | ENSP00000083182 | Homeodomain-interacting protein kinase 4; Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential) | Amyloid protein-binding protein 2; May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface | 0.730 |
| HIPK4 | ATP5SL | ENSP00000291823 | ENSP00000403910 | Homeodomain-interacting protein kinase 4; Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential) | Distal membrane-arm assembly complex protein 2; Required for the assembly of the mitochondrial NADH-ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I; Belongs to the ATP synthase subunit s family | 0.557 |
| HIPK4 | DCAF7 | ENSP00000291823 | ENSP00000483236 | Homeodomain-interacting protein kinase 4; Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential) | DDB1- and CUL4-associated factor 7; Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches (By similarity). Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in normal and disease skin development. May function as a substrate receptor for CUL4- DDB1 E3 ubiquitin-protein ligase complex; Belongs to the WD repeat DCAF7 family | 0.684 |
| HIPK4 | FGL1 | ENSP00000291823 | ENSP00000381133 | Homeodomain-interacting protein kinase 4; Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential) | Fibrinogen-like protein 1; Has hepatocyte mitogenic activity; Fibrinogen C domain containing | 0.709 |
| HIPK4 | IRGQ | ENSP00000291823 | ENSP00000387535 | Homeodomain-interacting protein kinase 4; Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential) | Immunity-related GTPase family Q protein; Immunity related GTPase Q; Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family | 0.550 |
| HIPK4 | PLD3 | ENSP00000291823 | ENSP00000387050 | Homeodomain-interacting protein kinase 4; Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential) | Phospholipase D3; May be involved in APP processing; Belongs to the phospholipase D family | 0.908 |
| HIPK4 | RASSF5 | ENSP00000291823 | ENSP00000462099 | Homeodomain-interacting protein kinase 4; Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential) | Ras association domain-containing protein 5; Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras [...] | 0.806 |
| HIPK4 | TP53 | ENSP00000291823 | ENSP00000269305 | Homeodomain-interacting protein kinase 4; Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential) | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in [...] | 0.907 |
| HIPK4 | TTC9B | ENSP00000291823 | ENSP00000311760 | Homeodomain-interacting protein kinase 4; Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential) | Tetratricopeptide repeat domain containing | 0.600 |
| HIPK4 | ZNF146 | ENSP00000291823 | ENSP00000400391 | Homeodomain-interacting protein kinase 4; Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential) | Zinc finger protein 146; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.649 |
| IRGQ | ATP5SL | ENSP00000387535 | ENSP00000403910 | Immunity-related GTPase family Q protein; Immunity related GTPase Q; Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family | Distal membrane-arm assembly complex protein 2; Required for the assembly of the mitochondrial NADH-ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I; Belongs to the ATP synthase subunit s family | 0.582 |
| IRGQ | HIPK4 | ENSP00000387535 | ENSP00000291823 | Immunity-related GTPase family Q protein; Immunity related GTPase Q; Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family | Homeodomain-interacting protein kinase 4; Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential) | 0.550 |
| IRGQ | TTC9B | ENSP00000387535 | ENSP00000311760 | Immunity-related GTPase family Q protein; Immunity related GTPase Q; Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family | Tetratricopeptide repeat domain containing | 0.584 |
