HSPB4 protein (human) - STRING database

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

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HSPB4

Crystallin, alpha A; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins (173 aa)

Predicted Functional Partners:

CRYBB2

0.956

CRYBB1

0.940

CRYBA1

0.938

CRYGC

0.902

CRYAB

0.898

CRYGD

0.880

CRYBB3

0.876

CRYBA4

0.860

GJA3

0.850

CRYGS

0.838

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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... protein annotations:

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a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRYAB	CRYBA1	ENSP00000433560	ENSP00000225387	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	Beta-crystallin A3; Crystallins are the dominant structural components of the vertebrate eye lens	0.873
CRYAB	CRYBA4	ENSP00000433560	ENSP00000346805	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	Beta-crystallin A4; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family	0.799
CRYAB	CRYBB1	ENSP00000433560	ENSP00000215939	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	Beta-crystallin B1; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family	0.852
CRYAB	CRYBB2	ENSP00000433560	ENSP00000381273	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	Beta-crystallin B2; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family	0.903
CRYAB	CRYBB3	ENSP00000433560	ENSP00000215855	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	Beta-crystallin B3; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family	0.808
CRYAB	CRYGC	ENSP00000433560	ENSP00000282141	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	Gamma-crystallin C; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family	0.833
CRYAB	CRYGD	ENSP00000433560	ENSP00000264376	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	Gamma-crystallin D; Crystallins are the dominant structural components of the vertebrate eye lens	0.805
CRYAB	CRYGS	ENSP00000433560	ENSP00000376287	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	Beta-crystallin S; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family	0.842
CRYAB	GJA3	ENSP00000433560	ENSP00000241125	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	Gap junction alpha-3 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Belongs to the connexin family. Alpha-type (group II) subfamily	0.729
CRYAB	HSPB4	ENSP00000433560	ENSP00000291554	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	Crystallin, alpha A; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	0.898
CRYBA1	CRYAB	ENSP00000225387	ENSP00000433560	Beta-crystallin A3; Crystallins are the dominant structural components of the vertebrate eye lens	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	0.873
CRYBA1	CRYBB1	ENSP00000225387	ENSP00000215939	Beta-crystallin A3; Crystallins are the dominant structural components of the vertebrate eye lens	Beta-crystallin B1; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family	0.721
CRYBA1	CRYBB2	ENSP00000225387	ENSP00000381273	Beta-crystallin A3; Crystallins are the dominant structural components of the vertebrate eye lens	Beta-crystallin B2; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family	0.413
CRYBA1	CRYBB3	ENSP00000225387	ENSP00000215855	Beta-crystallin A3; Crystallins are the dominant structural components of the vertebrate eye lens	Beta-crystallin B3; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family	0.424
CRYBA1	GJA3	ENSP00000225387	ENSP00000241125	Beta-crystallin A3; Crystallins are the dominant structural components of the vertebrate eye lens	Gap junction alpha-3 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Belongs to the connexin family. Alpha-type (group II) subfamily	0.818
CRYBA1	HSPB4	ENSP00000225387	ENSP00000291554	Beta-crystallin A3; Crystallins are the dominant structural components of the vertebrate eye lens	Crystallin, alpha A; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	0.938
CRYBA4	CRYAB	ENSP00000346805	ENSP00000433560	Beta-crystallin A4; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Small heat shock proteins	0.799
CRYBA4	CRYBB1	ENSP00000346805	ENSP00000215939	Beta-crystallin A4; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family	Beta-crystallin B1; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family	0.495
CRYBA4	CRYBB2	ENSP00000346805	ENSP00000381273	Beta-crystallin A4; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family	Beta-crystallin B2; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family	0.408
CRYBA4	GJA3	ENSP00000346805	ENSP00000241125	Beta-crystallin A4; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family	Gap junction alpha-3 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Belongs to the connexin family. Alpha-type (group II) subfamily	0.733

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