ANKRD18B protein (human) - STRING database

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ANKRD18B

Ankyrin repeat domain-containing protein 18B; Ankyrin repeat domain containing (1011 aa)

Predicted Functional Partners:

THAP8

0.669

RLF

0.553

FRMPD1

0.521

ANKRD32

0.502

ENSG00000216937

0.501

ENSG00000216937

0.501

ANKRD9

0.476

FAM8A1

0.475

POLR3B

0.430

DOC2B

0.426

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKRD18B	ANKRD32	ENSP00000290943	ENSP00000265140	Ankyrin repeat domain-containing protein 18B; Ankyrin repeat domain containing	SMC5-SMC6 complex localization factor protein 1; Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance. The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication- coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks. Promotes the recruitment of SLF2 and the SMC5-SMC6 complex to DNA lesions	0.502
ANKRD18B	ANKRD9	ENSP00000290943	ENSP00000286918	Ankyrin repeat domain-containing protein 18B; Ankyrin repeat domain containing	Ankyrin repeat domain-containing protein 9; Ankyrin repeat domain containing	0.476
ANKRD18B	DOC2B	ENSP00000290943	ENSP00000482950	Ankyrin repeat domain-containing protein 18B; Ankyrin repeat domain containing	Double C2-like domain-containing protein beta; Calcium sensor which positively regulates SNARE- dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membr [...]	0.426
ANKRD18B	ENSG00000216937	ENSP00000290943	ENSP00000355078	Ankyrin repeat domain-containing protein 18B; Ankyrin repeat domain containing	Coiled-coil domain-containing protein 7; May play a role in tumorigenesis	0.501
ANKRD18B	ENSG00000216937	ENSP00000290943	ENSP00000364165	Ankyrin repeat domain-containing protein 18B; Ankyrin repeat domain containing	Coiled-coil domain containing 7; May play a role in tumorigenesis	0.501
ANKRD18B	FAM8A1	ENSP00000290943	ENSP00000259963	Ankyrin repeat domain-containing protein 18B; Ankyrin repeat domain containing	Protein FAM8A1; Family with sequence similarity 8 member A1	0.475
ANKRD18B	FRMPD1	ENSP00000290943	ENSP00000444411	Ankyrin repeat domain-containing protein 18B; Ankyrin repeat domain containing	FERM and PDZ domain-containing protein 1; Stabilizes membrane-bound GPSM1, and thereby promotes its interaction with GNAI1; FERM domain containing	0.521
ANKRD18B	POLR3B	ENSP00000290943	ENSP00000228347	Ankyrin repeat domain-containing protein 18B; Ankyrin repeat domain containing	DNA-directed RNA polymerase III subunit RPC2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the clef [...]	0.430
ANKRD18B	RLF	ENSP00000290943	ENSP00000361857	Ankyrin repeat domain-containing protein 18B; Ankyrin repeat domain containing	Zinc finger protein Rlf; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family	0.553
ANKRD18B	THAP8	ENSP00000290943	ENSP00000292894	Ankyrin repeat domain-containing protein 18B; Ankyrin repeat domain containing	THAP domain containing 8	0.669
ANKRD32	ANKRD18B	ENSP00000265140	ENSP00000290943	SMC5-SMC6 complex localization factor protein 1; Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance. The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication- coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks. Promotes the recruitment of SLF2 and the SMC5-SMC6 complex to DNA lesions	Ankyrin repeat domain-containing protein 18B; Ankyrin repeat domain containing	0.502
ANKRD32	THAP8	ENSP00000265140	ENSP00000292894	SMC5-SMC6 complex localization factor protein 1; Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance. The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication- coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks. Promotes the recruitment of SLF2 and the SMC5-SMC6 complex to DNA lesions	THAP domain containing 8	0.553
ANKRD9	ANKRD18B	ENSP00000286918	ENSP00000290943	Ankyrin repeat domain-containing protein 9; Ankyrin repeat domain containing	Ankyrin repeat domain-containing protein 18B; Ankyrin repeat domain containing	0.476
ANKRD9	FAM8A1	ENSP00000286918	ENSP00000259963	Ankyrin repeat domain-containing protein 9; Ankyrin repeat domain containing	Protein FAM8A1; Family with sequence similarity 8 member A1	0.444
DOC2B	ANKRD18B	ENSP00000482950	ENSP00000290943	Double C2-like domain-containing protein beta; Calcium sensor which positively regulates SNARE- dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membr [...]	Ankyrin repeat domain-containing protein 18B; Ankyrin repeat domain containing	0.426
ENSG00000216937	ANKRD18B	ENSP00000364165	ENSP00000290943	Coiled-coil domain containing 7; May play a role in tumorigenesis	Ankyrin repeat domain-containing protein 18B; Ankyrin repeat domain containing	0.501
ENSG00000216937	ANKRD18B	ENSP00000355078	ENSP00000290943	Coiled-coil domain-containing protein 7; May play a role in tumorigenesis	Ankyrin repeat domain-containing protein 18B; Ankyrin repeat domain containing	0.501
ENSG00000216937	ENSG00000216937	ENSP00000355078	ENSP00000364165	Coiled-coil domain-containing protein 7; May play a role in tumorigenesis	Coiled-coil domain containing 7; May play a role in tumorigenesis	0.634
ENSG00000216937	ENSG00000216937	ENSP00000364165	ENSP00000355078	Coiled-coil domain containing 7; May play a role in tumorigenesis	Coiled-coil domain-containing protein 7; May play a role in tumorigenesis	0.634
ENSG00000216937	FRMPD1	ENSP00000364165	ENSP00000444411	Coiled-coil domain containing 7; May play a role in tumorigenesis	FERM and PDZ domain-containing protein 1; Stabilizes membrane-bound GPSM1, and thereby promotes its interaction with GNAI1; FERM domain containing	0.420

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