node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C3orf30 | GOLGA6A | ENSP00000295622 | ENSP00000290438 | Uncharacterized protein C3orf30; Chromosome 3 open reading frame 30 | Golgin A6 family member A; Belongs to the GOLGA6 family | 0.447 |
CCDC33 | GOLGA6A | ENSP00000381795 | ENSP00000290438 | Coiled-coil domain containing 33 | Golgin A6 family member A; Belongs to the GOLGA6 family | 0.485 |
CCDC33 | UBL7 | ENSP00000381795 | ENSP00000457703 | Coiled-coil domain containing 33 | Ubiquitin-like protein 7; Ubiquitin like 7 | 0.780 |
DACH2 | GOLGA6A | ENSP00000362217 | ENSP00000290438 | Dachshund homolog 2; Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression seems also to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by the overlyin [...] | Golgin A6 family member A; Belongs to the GOLGA6 family | 0.473 |
DCSTAMP | GOLGA6A | ENSP00000297581 | ENSP00000290438 | Dendritic cell-specific transmembrane protein; Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage. I [...] | Golgin A6 family member A; Belongs to the GOLGA6 family | 0.448 |
DCSTAMP | NUP205 | ENSP00000297581 | ENSP00000285968 | Dendritic cell-specific transmembrane protein; Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage. I [...] | Nuclear pore complex protein Nup205; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor NUP62 and other nucleoporins, but not NUP153 and TPR, to the NPC; Armadillo-like helical domain containing | 0.410 |
DCSTAMP | RIN3 | ENSP00000297581 | ENSP00000216487 | Dendritic cell-specific transmembrane protein; Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage. I [...] | Ras and Rab interactor 3; Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function; Belongs to the RIN (Ras interaction/interference) family | 0.406 |
GOLGA6A | C3orf30 | ENSP00000290438 | ENSP00000295622 | Golgin A6 family member A; Belongs to the GOLGA6 family | Uncharacterized protein C3orf30; Chromosome 3 open reading frame 30 | 0.447 |
GOLGA6A | CCDC33 | ENSP00000290438 | ENSP00000381795 | Golgin A6 family member A; Belongs to the GOLGA6 family | Coiled-coil domain containing 33 | 0.485 |
GOLGA6A | DACH2 | ENSP00000290438 | ENSP00000362217 | Golgin A6 family member A; Belongs to the GOLGA6 family | Dachshund homolog 2; Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression seems also to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by the overlyin [...] | 0.473 |
GOLGA6A | DCSTAMP | ENSP00000290438 | ENSP00000297581 | Golgin A6 family member A; Belongs to the GOLGA6 family | Dendritic cell-specific transmembrane protein; Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage. I [...] | 0.448 |
GOLGA6A | ISLR2 | ENSP00000290438 | ENSP00000355402 | Golgin A6 family member A; Belongs to the GOLGA6 family | Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development; Immunoglobulin like domain containing | 0.477 |
GOLGA6A | NUP205 | ENSP00000290438 | ENSP00000285968 | Golgin A6 family member A; Belongs to the GOLGA6 family | Nuclear pore complex protein Nup205; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor NUP62 and other nucleoporins, but not NUP153 and TPR, to the NPC; Armadillo-like helical domain containing | 0.560 |
GOLGA6A | RIN3 | ENSP00000290438 | ENSP00000216487 | Golgin A6 family member A; Belongs to the GOLGA6 family | Ras and Rab interactor 3; Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function; Belongs to the RIN (Ras interaction/interference) family | 0.530 |
GOLGA6A | STOML1 | ENSP00000290438 | ENSP00000442478 | Golgin A6 family member A; Belongs to the GOLGA6 family | Stomatin-like protein 1; May play a role in cholesterol transfer to late endosomes. May play a role in modulating membrane acid-sensing ion channels. Can specifically inhibit proton-gated current of ASIC1 isoform 1. Can increase inactivation speed of ASIC3. May be involved in regulation of proton sensing in dorsal root ganglions (By similarity). May play a role in protecting FBXW7 isoform 3 from degradation; Belongs to the band 7/mec-2 family | 0.530 |
GOLGA6A | UBL7 | ENSP00000290438 | ENSP00000457703 | Golgin A6 family member A; Belongs to the GOLGA6 family | Ubiquitin-like protein 7; Ubiquitin like 7 | 0.520 |
GOLGA6A | USO1 | ENSP00000290438 | ENSP00000444850 | Golgin A6 family member A; Belongs to the GOLGA6 family | General vesicular transport factor p115; General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity; Armadillo-like helical domain containing | 0.558 |
ISLR2 | GOLGA6A | ENSP00000355402 | ENSP00000290438 | Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development; Immunoglobulin like domain containing | Golgin A6 family member A; Belongs to the GOLGA6 family | 0.477 |
NUP205 | DCSTAMP | ENSP00000285968 | ENSP00000297581 | Nuclear pore complex protein Nup205; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor NUP62 and other nucleoporins, but not NUP153 and TPR, to the NPC; Armadillo-like helical domain containing | Dendritic cell-specific transmembrane protein; Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage. I [...] | 0.410 |
NUP205 | GOLGA6A | ENSP00000285968 | ENSP00000290438 | Nuclear pore complex protein Nup205; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor NUP62 and other nucleoporins, but not NUP153 and TPR, to the NPC; Armadillo-like helical domain containing | Golgin A6 family member A; Belongs to the GOLGA6 family | 0.560 |