C2orf81 protein (human) - STRING database

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C2orf81

Uncharacterized protein C2orf81; Chromosome 2 open reading frame 81 (588 aa)

Predicted Functional Partners:

CCDC154

0.789

C7orf73

0.709

TCEB3B

0.708

KIAA1683

0.670

JAKMIP3

0.641

MYO3B

0.561

PPAP2C

0.533

RHBDF1

0.528

CHPF

0.479

AGAP2

0.477

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGAP2	C2orf81	ENSP00000449241	ENSP00000290390	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2; GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also r [...]	Uncharacterized protein C2orf81; Chromosome 2 open reading frame 81	0.477
AGAP2	CCDC154	ENSP00000449241	ENSP00000373828	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2; GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also r [...]	Coiled-coil domain containing 154	0.492
C2orf81	AGAP2	ENSP00000290390	ENSP00000449241	Uncharacterized protein C2orf81; Chromosome 2 open reading frame 81	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2; GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also r [...]	0.477
C2orf81	C7orf73	ENSP00000290390	ENSP00000425996	Uncharacterized protein C2orf81; Chromosome 2 open reading frame 81	Short transmembrane mitochondrial protein 1; Chromosome 7 open reading frame 73	0.709
C2orf81	CCDC154	ENSP00000290390	ENSP00000373828	Uncharacterized protein C2orf81; Chromosome 2 open reading frame 81	Coiled-coil domain containing 154	0.789
C2orf81	CHPF	ENSP00000290390	ENSP00000243776	Uncharacterized protein C2orf81; Chromosome 2 open reading frame 81	Chondroitin sulfate synthase 2; Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Isoform 2 may facilitate PRKN transport into the mitochondria. In collaboration with PRKN, isoform 2 may enhance cell viability and protect cells from oxidative stress	0.479
C2orf81	JAKMIP3	ENSP00000290390	ENSP00000298622	Uncharacterized protein C2orf81; Chromosome 2 open reading frame 81	Janus kinase and microtubule interacting protein 3	0.641
C2orf81	KIAA1683	ENSP00000290390	ENSP00000376213	Uncharacterized protein C2orf81; Chromosome 2 open reading frame 81	IQ domain-containing protein N; KIAA1683	0.670
C2orf81	MYO3B	ENSP00000290390	ENSP00000386213	Uncharacterized protein C2orf81; Chromosome 2 open reading frame 81	Myosin-IIIb; Probable actin-based motor with a protein kinase activity. Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filame [...]	0.561
C2orf81	PPAP2C	ENSP00000290390	ENSP00000329697	Uncharacterized protein C2orf81; Chromosome 2 open reading frame 81	Phospholipid phosphatase 2; Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1- phosphate (S-1-P). The relative catalytic efficiency is PA > C-1-P > LPA > S-1-P; Belongs to the PA-phosphatase related phosphoesterase family	0.533
C2orf81	RHBDF1	ENSP00000290390	ENSP00000262316	Uncharacterized protein C2orf81; Chromosome 2 open reading frame 81	Inactive rhomboid protein 1; Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activates the epidermal growth factor receptor signaling pathway and may thereby regulate sleep, cell survival, proliferation and migration	0.528
C2orf81	TCEB3B	ENSP00000290390	ENSP00000331302	Uncharacterized protein C2orf81; Chromosome 2 open reading frame 81	Elongin-A2; SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A2 is transcriptionally active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex)	0.708
C7orf73	C2orf81	ENSP00000425996	ENSP00000290390	Short transmembrane mitochondrial protein 1; Chromosome 7 open reading frame 73	Uncharacterized protein C2orf81; Chromosome 2 open reading frame 81	0.709
C7orf73	CCDC154	ENSP00000425996	ENSP00000373828	Short transmembrane mitochondrial protein 1; Chromosome 7 open reading frame 73	Coiled-coil domain containing 154	0.709
C7orf73	CHPF	ENSP00000425996	ENSP00000243776	Short transmembrane mitochondrial protein 1; Chromosome 7 open reading frame 73	Chondroitin sulfate synthase 2; Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Isoform 2 may facilitate PRKN transport into the mitochondria. In collaboration with PRKN, isoform 2 may enhance cell viability and protect cells from oxidative stress	0.410
C7orf73	JAKMIP3	ENSP00000425996	ENSP00000298622	Short transmembrane mitochondrial protein 1; Chromosome 7 open reading frame 73	Janus kinase and microtubule interacting protein 3	0.550
C7orf73	KIAA1683	ENSP00000425996	ENSP00000376213	Short transmembrane mitochondrial protein 1; Chromosome 7 open reading frame 73	IQ domain-containing protein N; KIAA1683	0.590
C7orf73	MYO3B	ENSP00000425996	ENSP00000386213	Short transmembrane mitochondrial protein 1; Chromosome 7 open reading frame 73	Myosin-IIIb; Probable actin-based motor with a protein kinase activity. Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filame [...]	0.471
C7orf73	PPAP2C	ENSP00000425996	ENSP00000329697	Short transmembrane mitochondrial protein 1; Chromosome 7 open reading frame 73	Phospholipid phosphatase 2; Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1- phosphate (S-1-P). The relative catalytic efficiency is PA > C-1-P > LPA > S-1-P; Belongs to the PA-phosphatase related phosphoesterase family	0.440
C7orf73	RHBDF1	ENSP00000425996	ENSP00000262316	Short transmembrane mitochondrial protein 1; Chromosome 7 open reading frame 73	Inactive rhomboid protein 1; Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activates the epidermal growth factor receptor signaling pathway and may thereby regulate sleep, cell survival, proliferation and migration	0.429

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