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STRINGSTRING
TPRN TPRN BEST1 BEST1 BEST3 BEST3 CLIC6 CLIC6 GABRP GABRP CLIC4 CLIC4 BEST2 BEST2 NIPAL3 NIPAL3 CFTR CFTR ANO1 ANO1 BEST4 BEST4
"CLIC6" - Chloride intracellular channel protein 6 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
CLIC6Chloride intracellular channel protein 6; May insert into membranes and form chloride ion channels. May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport (By similarity) (686 aa)    
Predicted Functional Partners:
CLIC4
Chloride intracellular channel protein 4; Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell- surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical- basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis) (253 aa)
        
0.853
GABRP
Gamma-aminobutyric acid receptor subunit pi; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. In the uterus, the function of the receptor appears to be related to tissue contractility. The binding of this pI subunit with other GABA(A) receptor subunits alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfa [...] (440 aa)
      
 
  0.713
TPRN
Taperin; Deafness associated genes (711 aa)
            
  0.660
BEST2
Bestrophin-2; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Bestrophins (509 aa)
          
  0.651
BEST1
Bestrophin-1; Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate; Bestrophins (604 aa)
          
  0.639
NIPAL3
NIPA-like protein 3; NIPA like domain containing 3 (406 aa)
            
  0.634
BEST4
Bestrophin-4; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Bestrophins (473 aa)
          
  0.631
CFTR
Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Plays an important role in airway fluid homeostasis. Contributes to the regulation of the pH [...] (1480 aa)
      
 
  0.621
BEST3
Bestrophin-3; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family (668 aa)
          
  0.619
ANO1
Anoctamin-1; Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development; Belongs to the anoctamin family (986 aa)
      
 
  0.613
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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