FAM46B protein (human) - STRING database

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FAM46B

Putative nucleotidyltransferase FAM46B; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase (425 aa)

Predicted Functional Partners:

FRA10AC1

0.710

CMTM4

0.555

MB21D2

0.514

ITPRIPL1

0.513

ITPRIPL2

0.511

MAB21L3

0.507

OLFML3

0.494

AUNIP

0.491

C6orf136

0.479

C2orf54

0.473

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AUNIP	C6orf136	ENSP00000443647	ENSP00000293604	Aurora kinase A and ninein-interacting protein; DNA-binding protein that accumulates at DNA double- strand breaks (DSBs) following DNA damage and promotes DNA resection and homologous recombination. Serves as a sensor of DNA damage- binds DNA with a strong preference for DNA substrates that mimic structures generated at stalled replication forks, and anchors RBBP8/CtIP to DSB sites to promote DNA end resection and ensuing homologous recombination repair. Inhibits non-homologous end joining (NHEJ). Required for the dynamic movement of AURKA at the centrosomes and spindle apparatus durin [...]	Uncharacterized protein C6orf136; Chromosome 6 open reading frame 136	0.556
AUNIP	FAM46B	ENSP00000443647	ENSP00000289166	Aurora kinase A and ninein-interacting protein; DNA-binding protein that accumulates at DNA double- strand breaks (DSBs) following DNA damage and promotes DNA resection and homologous recombination. Serves as a sensor of DNA damage- binds DNA with a strong preference for DNA substrates that mimic structures generated at stalled replication forks, and anchors RBBP8/CtIP to DSB sites to promote DNA end resection and ensuing homologous recombination repair. Inhibits non-homologous end joining (NHEJ). Required for the dynamic movement of AURKA at the centrosomes and spindle apparatus durin [...]	Putative nucleotidyltransferase FAM46B; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase	0.491
C2orf54	FAM46B	ENSP00000373586	ENSP00000289166	Uncharacterized protein C2orf54; Chromosome 2 open reading frame 54	Putative nucleotidyltransferase FAM46B; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase	0.473
C2orf54	ITPRIPL1	ENSP00000373586	ENSP00000355121	Uncharacterized protein C2orf54; Chromosome 2 open reading frame 54	Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1; ITPRIP like 1	0.528
C2orf54	ITPRIPL2	ENSP00000373586	ENSP00000370849	Uncharacterized protein C2orf54; Chromosome 2 open reading frame 54	Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2; ITPRIP like 2	0.533
C2orf54	MB21D2	ENSP00000373586	ENSP00000376246	Uncharacterized protein C2orf54; Chromosome 2 open reading frame 54	Protein MB21D2; Mab-21 domain containing 2	0.473
C6orf136	AUNIP	ENSP00000293604	ENSP00000443647	Uncharacterized protein C6orf136; Chromosome 6 open reading frame 136	Aurora kinase A and ninein-interacting protein; DNA-binding protein that accumulates at DNA double- strand breaks (DSBs) following DNA damage and promotes DNA resection and homologous recombination. Serves as a sensor of DNA damage- binds DNA with a strong preference for DNA substrates that mimic structures generated at stalled replication forks, and anchors RBBP8/CtIP to DSB sites to promote DNA end resection and ensuing homologous recombination repair. Inhibits non-homologous end joining (NHEJ). Required for the dynamic movement of AURKA at the centrosomes and spindle apparatus durin [...]	0.556
C6orf136	FAM46B	ENSP00000293604	ENSP00000289166	Uncharacterized protein C6orf136; Chromosome 6 open reading frame 136	Putative nucleotidyltransferase FAM46B; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase	0.479
CMTM4	FAM46B	ENSP00000333833	ENSP00000289166	CKLF like MARVEL transmembrane domain containing 4	Putative nucleotidyltransferase FAM46B; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase	0.555
FAM46B	AUNIP	ENSP00000289166	ENSP00000443647	Putative nucleotidyltransferase FAM46B; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase	Aurora kinase A and ninein-interacting protein; DNA-binding protein that accumulates at DNA double- strand breaks (DSBs) following DNA damage and promotes DNA resection and homologous recombination. Serves as a sensor of DNA damage- binds DNA with a strong preference for DNA substrates that mimic structures generated at stalled replication forks, and anchors RBBP8/CtIP to DSB sites to promote DNA end resection and ensuing homologous recombination repair. Inhibits non-homologous end joining (NHEJ). Required for the dynamic movement of AURKA at the centrosomes and spindle apparatus durin [...]	0.491
FAM46B	C2orf54	ENSP00000289166	ENSP00000373586	Putative nucleotidyltransferase FAM46B; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase	Uncharacterized protein C2orf54; Chromosome 2 open reading frame 54	0.473
FAM46B	C6orf136	ENSP00000289166	ENSP00000293604	Putative nucleotidyltransferase FAM46B; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase	Uncharacterized protein C6orf136; Chromosome 6 open reading frame 136	0.479
FAM46B	CMTM4	ENSP00000289166	ENSP00000333833	Putative nucleotidyltransferase FAM46B; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase	CKLF like MARVEL transmembrane domain containing 4	0.555
FAM46B	FRA10AC1	ENSP00000289166	ENSP00000360488	Putative nucleotidyltransferase FAM46B; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase	Protein FRA10AC1; FRA10A associated CGG repeat 1; Spliceosomal C complex	0.710
FAM46B	ITPRIPL1	ENSP00000289166	ENSP00000355121	Putative nucleotidyltransferase FAM46B; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase	Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1; ITPRIP like 1	0.513
FAM46B	ITPRIPL2	ENSP00000289166	ENSP00000370849	Putative nucleotidyltransferase FAM46B; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase	Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2; ITPRIP like 2	0.511
FAM46B	MAB21L3	ENSP00000289166	ENSP00000358512	Putative nucleotidyltransferase FAM46B; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase	Protein mab-21-like 3; Mab-21 like 3	0.507
FAM46B	MB21D2	ENSP00000289166	ENSP00000376246	Putative nucleotidyltransferase FAM46B; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase	Protein MB21D2; Mab-21 domain containing 2	0.514
FAM46B	OLFML3	ENSP00000289166	ENSP00000322273	Putative nucleotidyltransferase FAM46B; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase	Olfactomedin-like protein 3; Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity). May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processes; Belongs to the OLFML3 family	0.494
FRA10AC1	FAM46B	ENSP00000360488	ENSP00000289166	Protein FRA10AC1; FRA10A associated CGG repeat 1; Spliceosomal C complex	Putative nucleotidyltransferase FAM46B; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase	0.710

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