CIB4 protein (human) - STRING database

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CIB4

Calcium and integrin binding family member 4; EF-hand domain containing (185 aa)

Predicted Functional Partners:

FGF19

0.694

FAM181B

0.634

TCF23

0.547

SNX17

0.545

PPM1G

0.529

PPP3CC

0.514

PPP3CA

0.514

PPP3CB

0.514

FKBP1B

0.498

DFNB31

0.490

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CIB4	DFNB31	ENSP00000288861	ENSP00000354623	Calcium and integrin binding family member 4; EF-hand domain containing	Whirlin; Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear	0.490
CIB4	FAM181B	ENSP00000288861	ENSP00000365295	Calcium and integrin binding family member 4; EF-hand domain containing	Protein FAM181B; Family with sequence similarity 181 member B; Belongs to the FAM181 family	0.634
CIB4	FGF19	ENSP00000288861	ENSP00000294312	Calcium and integrin binding family member 4; EF-hand domain containing	Fibroblast growth factor 19; Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4; Belongs to the heparin-binding growth factors family	0.694
CIB4	FKBP1B	ENSP00000288861	ENSP00000370373	Calcium and integrin binding family member 4; EF-hand domain containing	Peptidyl-prolyl cis-trans isomerase FKBP1B; Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the FKBP-type PPIase family. FKBP1 subfamily	0.498
CIB4	PPM1G	ENSP00000288861	ENSP00000342778	Calcium and integrin binding family member 4; EF-hand domain containing	Protein phosphatase, Mg2+/Mn2+ dependent 1G; Belongs to the PP2C family	0.529
CIB4	PPP3CA	ENSP00000288861	ENSP00000378323	Calcium and integrin binding family member 4; EF-hand domain containing	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase. Many of the substrates contain a PxIxIT motif. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1; Belongs to the PPP phosphatase family. PP-2B subfamily	0.514
CIB4	PPP3CB	ENSP00000288861	ENSP00000378306	Calcium and integrin binding family member 4; EF-hand domain containing	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin	0.514
CIB4	PPP3CC	ENSP00000288861	ENSP00000380878	Calcium and integrin binding family member 4; EF-hand domain containing	Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin; Belongs to the PPP phosphatase family. PP-2B subfamily	0.514
CIB4	SNX17	ENSP00000288861	ENSP00000233575	Calcium and integrin binding family member 4; EF-hand domain containing	Sorting nexin-17; Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Plays a role in the sorting of endocytosed LRP1 and APP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Recycles internalized integrins ITGB1, ITGB5 and their associated alpha subunits, preventing them from lysosomal degradation. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P))	0.545
CIB4	TCF23	ENSP00000288861	ENSP00000296096	Calcium and integrin binding family member 4; EF-hand domain containing	Transcription factor 23; Inhibits E-box-mediated binding and transactivation of bHLH factors. Inhibitory effect is similar to that of ID proteins. Inhibits the formation of TCF3 and MYOD1 homodimers and heterodimers. Lacks DNA binding activity. Seems to play a role in the inhibition of myogenesis (By similarity); Basic helix-loop-helix proteins	0.547
DFNB31	CIB4	ENSP00000354623	ENSP00000288861	Whirlin; Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear	Calcium and integrin binding family member 4; EF-hand domain containing	0.490
FAM181B	CIB4	ENSP00000365295	ENSP00000288861	Protein FAM181B; Family with sequence similarity 181 member B; Belongs to the FAM181 family	Calcium and integrin binding family member 4; EF-hand domain containing	0.634
FAM181B	PPM1G	ENSP00000365295	ENSP00000342778	Protein FAM181B; Family with sequence similarity 181 member B; Belongs to the FAM181 family	Protein phosphatase, Mg2+/Mn2+ dependent 1G; Belongs to the PP2C family	0.579
FAM181B	SNX17	ENSP00000365295	ENSP00000233575	Protein FAM181B; Family with sequence similarity 181 member B; Belongs to the FAM181 family	Sorting nexin-17; Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Plays a role in the sorting of endocytosed LRP1 and APP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Recycles internalized integrins ITGB1, ITGB5 and their associated alpha subunits, preventing them from lysosomal degradation. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P))	0.657
FGF19	CIB4	ENSP00000294312	ENSP00000288861	Fibroblast growth factor 19; Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4; Belongs to the heparin-binding growth factors family	Calcium and integrin binding family member 4; EF-hand domain containing	0.694
FKBP1B	CIB4	ENSP00000370373	ENSP00000288861	Peptidyl-prolyl cis-trans isomerase FKBP1B; Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the FKBP-type PPIase family. FKBP1 subfamily	Calcium and integrin binding family member 4; EF-hand domain containing	0.498
FKBP1B	PPP3CA	ENSP00000370373	ENSP00000378323	Peptidyl-prolyl cis-trans isomerase FKBP1B; Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the FKBP-type PPIase family. FKBP1 subfamily	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase. Many of the substrates contain a PxIxIT motif. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1; Belongs to the PPP phosphatase family. PP-2B subfamily	0.426
FKBP1B	PPP3CB	ENSP00000370373	ENSP00000378306	Peptidyl-prolyl cis-trans isomerase FKBP1B; Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the FKBP-type PPIase family. FKBP1 subfamily	Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin	0.421
FKBP1B	PPP3CC	ENSP00000370373	ENSP00000380878	Peptidyl-prolyl cis-trans isomerase FKBP1B; Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the FKBP-type PPIase family. FKBP1 subfamily	Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin; Belongs to the PPP phosphatase family. PP-2B subfamily	0.448
PPM1G	CIB4	ENSP00000342778	ENSP00000288861	Protein phosphatase, Mg2+/Mn2+ dependent 1G; Belongs to the PP2C family	Calcium and integrin binding family member 4; EF-hand domain containing	0.529

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