ZNF19 protein (human) - STRING database

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ZNF19

Zinc finger protein 19; May be involved in transcriptional regulation; Zinc fingers C2H2-type (458 aa)

Predicted Functional Partners:

TRIM28

0.953

NOX4

0.719

FRA10AC1

0.557

C1orf21

0.543

TRIM39

0.537

ZBED9

0.496

ELMSAN1

0.492

CEP170

0.418

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C1orf21	ELMSAN1	ENSP00000235307	ENSP00000286523	Uncharacterized protein C1orf21; Chromosome 1 open reading frame 21	ELM2 and Myb/SANT domain containing 1	0.476
C1orf21	ZNF19	ENSP00000235307	ENSP00000288177	Uncharacterized protein C1orf21; Chromosome 1 open reading frame 21	Zinc finger protein 19; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.543
CEP170	ZNF19	ENSP00000355500	ENSP00000288177	Centrosomal protein of 170 kDa; Plays a role in microtubule organization. Required for centriole subdistal appendage assembly; Belongs to the CEP170 family	Zinc finger protein 19; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.418
ELMSAN1	C1orf21	ENSP00000286523	ENSP00000235307	ELM2 and Myb/SANT domain containing 1	Uncharacterized protein C1orf21; Chromosome 1 open reading frame 21	0.476
ELMSAN1	ZNF19	ENSP00000286523	ENSP00000288177	ELM2 and Myb/SANT domain containing 1	Zinc finger protein 19; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.492
FRA10AC1	ZNF19	ENSP00000360488	ENSP00000288177	Protein FRA10AC1; FRA10A associated CGG repeat 1; Spliceosomal C complex	Zinc finger protein 19; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.557
NOX4	ZNF19	ENSP00000263317	ENSP00000288177	NADPH oxidase 4; Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 5 and is [...]	Zinc finger protein 19; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.719
TRIM28	ZNF19	ENSP00000253024	ENSP00000288177	Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...]	Zinc finger protein 19; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.953
TRIM39	ZNF19	ENSP00000365844	ENSP00000288177	E3 ubiquitin-protein ligase TRIM39; E3 ubiquitin-protein ligase. May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1; Ring finger proteins	Zinc finger protein 19; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.537
ZBED9	ZNF19	ENSP00000395259	ENSP00000288177	SCAN domain-containing protein 3; Zinc finger BED-type containing 9; SCAN domain containing	Zinc finger protein 19; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.496
ZNF19	C1orf21	ENSP00000288177	ENSP00000235307	Zinc finger protein 19; May be involved in transcriptional regulation; Zinc fingers C2H2-type	Uncharacterized protein C1orf21; Chromosome 1 open reading frame 21	0.543
ZNF19	CEP170	ENSP00000288177	ENSP00000355500	Zinc finger protein 19; May be involved in transcriptional regulation; Zinc fingers C2H2-type	Centrosomal protein of 170 kDa; Plays a role in microtubule organization. Required for centriole subdistal appendage assembly; Belongs to the CEP170 family	0.418
ZNF19	ELMSAN1	ENSP00000288177	ENSP00000286523	Zinc finger protein 19; May be involved in transcriptional regulation; Zinc fingers C2H2-type	ELM2 and Myb/SANT domain containing 1	0.492
ZNF19	FRA10AC1	ENSP00000288177	ENSP00000360488	Zinc finger protein 19; May be involved in transcriptional regulation; Zinc fingers C2H2-type	Protein FRA10AC1; FRA10A associated CGG repeat 1; Spliceosomal C complex	0.557
ZNF19	NOX4	ENSP00000288177	ENSP00000263317	Zinc finger protein 19; May be involved in transcriptional regulation; Zinc fingers C2H2-type	NADPH oxidase 4; Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 5 and is [...]	0.719
ZNF19	TRIM28	ENSP00000288177	ENSP00000253024	Zinc finger protein 19; May be involved in transcriptional regulation; Zinc fingers C2H2-type	Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...]	0.953
ZNF19	TRIM39	ENSP00000288177	ENSP00000365844	Zinc finger protein 19; May be involved in transcriptional regulation; Zinc fingers C2H2-type	E3 ubiquitin-protein ligase TRIM39; E3 ubiquitin-protein ligase. May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1; Ring finger proteins	0.537
ZNF19	ZBED9	ENSP00000288177	ENSP00000395259	Zinc finger protein 19; May be involved in transcriptional regulation; Zinc fingers C2H2-type	SCAN domain-containing protein 3; Zinc finger BED-type containing 9; SCAN domain containing	0.496

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2020

Credits

Access

Info

About