node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CYP51A1 | FDFT1 | ENSP00000003100 | ENSP00000480828 | Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4’-dimethyl cholesta-8,14,24-triene-3-beta-ol; Cytochrome P450 family 51 | Squalene synthase; Farnesyl-diphosphate farnesyltransferase 1 | 0.992 |
CYP51A1 | FDPS | ENSP00000003100 | ENSP00000349078 | Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4’-dimethyl cholesta-8,14,24-triene-3-beta-ol; Cytochrome P450 family 51 | Farnesyl pyrophosphate synthase; Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate | 0.943 |
CYP51A1 | HMGCR | ENSP00000003100 | ENSP00000287936 | Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4’-dimethyl cholesta-8,14,24-triene-3-beta-ol; Cytochrome P450 family 51 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase; Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins; Belongs to the HMG-CoA reductase family | 0.977 |
CYP51A1 | HMGCS1 | ENSP00000003100 | ENSP00000322706 | Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4’-dimethyl cholesta-8,14,24-triene-3-beta-ol; Cytochrome P450 family 51 | Hydroxymethylglutaryl-CoA synthase, cytoplasmic; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase | 0.986 |
CYP51A1 | HMGCS2 | ENSP00000003100 | ENSP00000358414 | Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4’-dimethyl cholesta-8,14,24-triene-3-beta-ol; Cytochrome P450 family 51 | Hydroxymethylglutaryl-CoA synthase, mitochondrial; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase | 0.801 |
CYP51A1 | IDI1 | ENSP00000003100 | ENSP00000370748 | Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4’-dimethyl cholesta-8,14,24-triene-3-beta-ol; Cytochrome P450 family 51 | Isopentenyl-diphosphate Delta-isomerase 1; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) | 0.975 |
CYP51A1 | MSMO1 | ENSP00000003100 | ENSP00000261507 | Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4’-dimethyl cholesta-8,14,24-triene-3-beta-ol; Cytochrome P450 family 51 | Methylsterol monooxygenase 1; Catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol; Belongs to the sterol desaturase family | 0.997 |
CYP51A1 | MVK | ENSP00000003100 | ENSP00000443551 | Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4’-dimethyl cholesta-8,14,24-triene-3-beta-ol; Cytochrome P450 family 51 | Mevalonate kinase; May be a regulatory site in cholesterol biosynthetic pathway; Belongs to the GHMP kinase family. Mevalonate kinase subfamily | 0.764 |
CYP51A1 | SQLE | ENSP00000003100 | ENSP00000265896 | Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4’-dimethyl cholesta-8,14,24-triene-3-beta-ol; Cytochrome P450 family 51 | Squalene monooxygenase; Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway; Belongs to the squalene monooxygenase family | 0.993 |
CYP51A1 | SREBF2 | ENSP00000003100 | ENSP00000354476 | Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4’-dimethyl cholesta-8,14,24-triene-3-beta-ol; Cytochrome P450 family 51 | Sterol regulatory element-binding protein 2; Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5’-ATCACCCCAC-3’) found in the flanking region of the LDRL and HMG-CoA synthase genes; Basic helix-loop-helix proteins | 0.968 |
FDFT1 | CYP51A1 | ENSP00000480828 | ENSP00000003100 | Squalene synthase; Farnesyl-diphosphate farnesyltransferase 1 | Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4’-dimethyl cholesta-8,14,24-triene-3-beta-ol; Cytochrome P450 family 51 | 0.992 |
FDFT1 | FDPS | ENSP00000480828 | ENSP00000349078 | Squalene synthase; Farnesyl-diphosphate farnesyltransferase 1 | Farnesyl pyrophosphate synthase; Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate | 0.997 |
FDFT1 | HMGCR | ENSP00000480828 | ENSP00000287936 | Squalene synthase; Farnesyl-diphosphate farnesyltransferase 1 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase; Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins; Belongs to the HMG-CoA reductase family | 0.936 |
FDFT1 | HMGCS1 | ENSP00000480828 | ENSP00000322706 | Squalene synthase; Farnesyl-diphosphate farnesyltransferase 1 | Hydroxymethylglutaryl-CoA synthase, cytoplasmic; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase | 0.939 |
FDFT1 | HMGCS2 | ENSP00000480828 | ENSP00000358414 | Squalene synthase; Farnesyl-diphosphate farnesyltransferase 1 | Hydroxymethylglutaryl-CoA synthase, mitochondrial; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase | 0.765 |
FDFT1 | IDI1 | ENSP00000480828 | ENSP00000370748 | Squalene synthase; Farnesyl-diphosphate farnesyltransferase 1 | Isopentenyl-diphosphate Delta-isomerase 1; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) | 0.986 |
FDFT1 | MSMO1 | ENSP00000480828 | ENSP00000261507 | Squalene synthase; Farnesyl-diphosphate farnesyltransferase 1 | Methylsterol monooxygenase 1; Catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol; Belongs to the sterol desaturase family | 0.991 |
FDFT1 | MVK | ENSP00000480828 | ENSP00000443551 | Squalene synthase; Farnesyl-diphosphate farnesyltransferase 1 | Mevalonate kinase; May be a regulatory site in cholesterol biosynthetic pathway; Belongs to the GHMP kinase family. Mevalonate kinase subfamily | 0.924 |
FDFT1 | SQLE | ENSP00000480828 | ENSP00000265896 | Squalene synthase; Farnesyl-diphosphate farnesyltransferase 1 | Squalene monooxygenase; Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway; Belongs to the squalene monooxygenase family | 0.997 |
FDFT1 | SREBF2 | ENSP00000480828 | ENSP00000354476 | Squalene synthase; Farnesyl-diphosphate farnesyltransferase 1 | Sterol regulatory element-binding protein 2; Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5’-ATCACCCCAC-3’) found in the flanking region of the LDRL and HMG-CoA synthase genes; Basic helix-loop-helix proteins | 0.967 |