| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| GPHN | LHFPL4 | ENSP00000417901 | ENSP00000287585 | Gephyrin; Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules. Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released; In the C-terminal section; belongs to the MoeA family | LHFPL tetraspan subfamily member 4 | 0.563 |
| GPHN | NLGN2 | ENSP00000417901 | ENSP00000305288 | Gephyrin; Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules. Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released; In the C-terminal section; belongs to the MoeA family | Neuroligin-2; Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma- aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of sign [...] | 0.891 |
| LHFPL4 | GPHN | ENSP00000287585 | ENSP00000417901 | LHFPL tetraspan subfamily member 4 | Gephyrin; Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules. Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released; In the C-terminal section; belongs to the MoeA family | 0.563 |
| LHFPL4 | MTMR14 | ENSP00000287585 | ENSP00000296003 | LHFPL tetraspan subfamily member 4 | Myotubularin-related protein 14; Lipid phosphatase which efficiently dephosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2; inactive toward PtdIns4P, PtdIns(3,4)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P3; Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily | 0.782 |
| LHFPL4 | NBEA | ENSP00000287585 | ENSP00000383295 | LHFPL tetraspan subfamily member 4 | Neurobeachin; Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity); Belongs to the WD repeat neurobeachin family | 0.669 |
| LHFPL4 | NLGN2 | ENSP00000287585 | ENSP00000305288 | LHFPL tetraspan subfamily member 4 | Neuroligin-2; Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma- aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of sign [...] | 0.733 |
| LHFPL4 | NOL4 | ENSP00000287585 | ENSP00000261592 | LHFPL tetraspan subfamily member 4 | Nucleolar protein 4 | 0.705 |
| LHFPL4 | PRRT3 | ENSP00000287585 | ENSP00000392511 | LHFPL tetraspan subfamily member 4 | Proline rich transmembrane protein 3 | 0.571 |
| LHFPL4 | SCP2D1 | ENSP00000287585 | ENSP00000366645 | LHFPL tetraspan subfamily member 4 | SCP2 sterol-binding domain-containing protein 1; SCP2 sterol binding domain containing 1 | 0.619 |
| LHFPL4 | SH3GL2 | ENSP00000287585 | ENSP00000369981 | LHFPL tetraspan subfamily member 4 | Endophilin-A1; Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes; N-BAR domain containing | 0.580 |
| LHFPL4 | SKIV2L2 | ENSP00000287585 | ENSP00000230640 | LHFPL tetraspan subfamily member 4 | Superkiller viralicidic activity 2-like 2; Component of exosome targeting complexes. Subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that directs a subset of non-coding short-lived RNAs for exosomal degradation. Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor SKIV2L2/MTR4, which links to RNA-binding protein ada [...] | 0.693 |
| LHFPL4 | TSPAN4 | ENSP00000287585 | ENSP00000380553 | LHFPL tetraspan subfamily member 4 | Tetraspanin-4; Tetraspanin 4; Belongs to the tetraspanin (TM4SF) family | 0.800 |
| MTMR14 | LHFPL4 | ENSP00000296003 | ENSP00000287585 | Myotubularin-related protein 14; Lipid phosphatase which efficiently dephosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2; inactive toward PtdIns4P, PtdIns(3,4)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P3; Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily | LHFPL tetraspan subfamily member 4 | 0.782 |
| MTMR14 | PRRT3 | ENSP00000296003 | ENSP00000392511 | Myotubularin-related protein 14; Lipid phosphatase which efficiently dephosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2; inactive toward PtdIns4P, PtdIns(3,4)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P3; Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily | Proline rich transmembrane protein 3 | 0.440 |
| NBEA | LHFPL4 | ENSP00000383295 | ENSP00000287585 | Neurobeachin; Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity); Belongs to the WD repeat neurobeachin family | LHFPL tetraspan subfamily member 4 | 0.669 |
| NBEA | NLGN2 | ENSP00000383295 | ENSP00000305288 | Neurobeachin; Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity); Belongs to the WD repeat neurobeachin family | Neuroligin-2; Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma- aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of sign [...] | 0.426 |
| NLGN2 | GPHN | ENSP00000305288 | ENSP00000417901 | Neuroligin-2; Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma- aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of sign [...] | Gephyrin; Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules. Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released; In the C-terminal section; belongs to the MoeA family | 0.891 |
| NLGN2 | LHFPL4 | ENSP00000305288 | ENSP00000287585 | Neuroligin-2; Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma- aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of sign [...] | LHFPL tetraspan subfamily member 4 | 0.733 |
| NLGN2 | NBEA | ENSP00000305288 | ENSP00000383295 | Neuroligin-2; Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma- aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of sign [...] | Neurobeachin; Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity); Belongs to the WD repeat neurobeachin family | 0.426 |
| NOL4 | LHFPL4 | ENSP00000261592 | ENSP00000287585 | Nucleolar protein 4 | LHFPL tetraspan subfamily member 4 | 0.705 |
