| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BFAR | NFXL1 | ENSP00000261658 | ENSP00000422037 | Bifunctional apoptosis regulator; Apoptosis regulator. Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors; Ring finger proteins | NF-X1-type zinc finger protein NFXL1; Nuclear transcription factor, X-box binding like 1; Belongs to the NFX1 family | 0.407 |
| BFAR | ZNF689 | ENSP00000261658 | ENSP00000287461 | Bifunctional apoptosis regulator; Apoptosis regulator. Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors; Ring finger proteins | Zinc finger protein 689; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.473 |
| CORO2B | ZNF689 | ENSP00000454783 | ENSP00000287461 | Coronin-2B; May play a role in the reorganization of neuronal actin structure; Belongs to the WD repeat coronin family | Zinc finger protein 689; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.455 |
| NFXL1 | BFAR | ENSP00000422037 | ENSP00000261658 | NF-X1-type zinc finger protein NFXL1; Nuclear transcription factor, X-box binding like 1; Belongs to the NFX1 family | Bifunctional apoptosis regulator; Apoptosis regulator. Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors; Ring finger proteins | 0.407 |
| NFXL1 | TGFBRAP1 | ENSP00000422037 | ENSP00000377027 | NF-X1-type zinc finger protein NFXL1; Nuclear transcription factor, X-box binding like 1; Belongs to the NFX1 family | Transforming growth factor-beta receptor-associated protein 1; Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2 | 0.403 |
| NFXL1 | ZNF689 | ENSP00000422037 | ENSP00000287461 | NF-X1-type zinc finger protein NFXL1; Nuclear transcription factor, X-box binding like 1; Belongs to the NFX1 family | Zinc finger protein 689; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.525 |
| POLE4 | TGFBRAP1 | ENSP00000420176 | ENSP00000377027 | DNA polymerase epsilon subunit 4; May play a role in allowing polymerase epsilon to carry out its replication and/or repair function; DNA polymerases | Transforming growth factor-beta receptor-associated protein 1; Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2 | 0.513 |
| POLE4 | TSNAX | ENSP00000420176 | ENSP00000355599 | DNA polymerase epsilon subunit 4; May play a role in allowing polymerase epsilon to carry out its replication and/or repair function; DNA polymerases | Translin-associated protein X; Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis | 0.410 |
| POLE4 | ZNF689 | ENSP00000420176 | ENSP00000287461 | DNA polymerase epsilon subunit 4; May play a role in allowing polymerase epsilon to carry out its replication and/or repair function; DNA polymerases | Zinc finger protein 689; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.563 |
| RPF1 | ZNF689 | ENSP00000359688 | ENSP00000287461 | Ribosome production factor 1; May be required for ribosome biogenesis | Zinc finger protein 689; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.742 |
| SETDB2 | ZNF689 | ENSP00000346175 | ENSP00000287461 | Histone-lysine N-methyltransferase SETDB2; Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates ’Lys-9’ of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis; Lysine methyltransferases | Zinc finger protein 689; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.469 |
| TGFBRAP1 | NFXL1 | ENSP00000377027 | ENSP00000422037 | Transforming growth factor-beta receptor-associated protein 1; Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2 | NF-X1-type zinc finger protein NFXL1; Nuclear transcription factor, X-box binding like 1; Belongs to the NFX1 family | 0.403 |
| TGFBRAP1 | POLE4 | ENSP00000377027 | ENSP00000420176 | Transforming growth factor-beta receptor-associated protein 1; Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2 | DNA polymerase epsilon subunit 4; May play a role in allowing polymerase epsilon to carry out its replication and/or repair function; DNA polymerases | 0.513 |
| TGFBRAP1 | ZNF689 | ENSP00000377027 | ENSP00000287461 | Transforming growth factor-beta receptor-associated protein 1; Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2 | Zinc finger protein 689; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.490 |
| TRIM28 | ZNF689 | ENSP00000253024 | ENSP00000287461 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 689; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.941 |
| TSNAX | POLE4 | ENSP00000355599 | ENSP00000420176 | Translin-associated protein X; Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis | DNA polymerase epsilon subunit 4; May play a role in allowing polymerase epsilon to carry out its replication and/or repair function; DNA polymerases | 0.410 |
| TSNAX | ZNF689 | ENSP00000355599 | ENSP00000287461 | Translin-associated protein X; Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis | Zinc finger protein 689; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.535 |
| ZNF474 | ZNF689 | ENSP00000296600 | ENSP00000287461 | Zinc finger protein 474; Zinc fingers C2H2-type | Zinc finger protein 689; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.491 |
| ZNF689 | BFAR | ENSP00000287461 | ENSP00000261658 | Zinc finger protein 689; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Bifunctional apoptosis regulator; Apoptosis regulator. Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors; Ring finger proteins | 0.473 |
| ZNF689 | CORO2B | ENSP00000287461 | ENSP00000454783 | Zinc finger protein 689; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Coronin-2B; May play a role in the reorganization of neuronal actin structure; Belongs to the WD repeat coronin family | 0.455 |
