| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AREL1 | FAM161B | ENSP00000348714 | ENSP00000286544 | Apoptosis-resistant E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits apoptosis by ubiquitinating and targeting for degradation a number of proapoptotic proteins including DIABLO/SMAC, HTRA2 and SEPT4/ARTS which are released from the mitochondrion into the cytosol following apoptotic stimulation | Protein FAM161B; Family with sequence similarity 161 member B; Belongs to the FAM161 family | 0.734 |
| AREL1 | FCF1 | ENSP00000348714 | ENSP00000344393 | Apoptosis-resistant E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits apoptosis by ubiquitinating and targeting for degradation a number of proapoptotic proteins including DIABLO/SMAC, HTRA2 and SEPT4/ARTS which are released from the mitochondrion into the cytosol following apoptotic stimulation | rRNA-processing protein FCF1 homolog; Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly | 0.615 |
| AREL1 | LIN52 | ENSP00000348714 | ENSP00000451812 | Apoptosis-resistant E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits apoptosis by ubiquitinating and targeting for degradation a number of proapoptotic proteins including DIABLO/SMAC, HTRA2 and SEPT4/ARTS which are released from the mitochondrion into the cytosol following apoptotic stimulation | Protein lin-52 homolog; Lin-52 DREAM MuvB core complex component | 0.487 |
| AREL1 | LRRC74A | ENSP00000348714 | ENSP00000377369 | Apoptosis-resistant E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits apoptosis by ubiquitinating and targeting for degradation a number of proapoptotic proteins including DIABLO/SMAC, HTRA2 and SEPT4/ARTS which are released from the mitochondrion into the cytosol following apoptotic stimulation | Leucine-rich repeat-containing protein 74A; Leucine rich repeat containing 74A | 0.766 |
| AREL1 | PTGR2 | ENSP00000348714 | ENSP00000452280 | Apoptosis-resistant E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits apoptosis by ubiquitinating and targeting for degradation a number of proapoptotic proteins including DIABLO/SMAC, HTRA2 and SEPT4/ARTS which are released from the mitochondrion into the cytosol following apoptotic stimulation | Prostaglandin reductase 2; Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto- PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation (By similarity) | 0.486 |
| FAM161B | AREL1 | ENSP00000286544 | ENSP00000348714 | Protein FAM161B; Family with sequence similarity 161 member B; Belongs to the FAM161 family | Apoptosis-resistant E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits apoptosis by ubiquitinating and targeting for degradation a number of proapoptotic proteins including DIABLO/SMAC, HTRA2 and SEPT4/ARTS which are released from the mitochondrion into the cytosol following apoptotic stimulation | 0.734 |
| FAM161B | FCF1 | ENSP00000286544 | ENSP00000344393 | Protein FAM161B; Family with sequence similarity 161 member B; Belongs to the FAM161 family | rRNA-processing protein FCF1 homolog; Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly | 0.713 |
| FAM161B | HCRTR2 | ENSP00000286544 | ENSP00000477548 | Protein FAM161B; Family with sequence similarity 161 member B; Belongs to the FAM161 family | Orexin receptor type 2; Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding; Hypocretin receptors | 0.659 |
| FAM161B | LCA5 | ENSP00000286544 | ENSP00000376686 | Protein FAM161B; Family with sequence similarity 161 member B; Belongs to the FAM161 family | Lebercilin; Might be involved in minus end-directed microtubule transport | 0.580 |
| FAM161B | LIN52 | ENSP00000286544 | ENSP00000451812 | Protein FAM161B; Family with sequence similarity 161 member B; Belongs to the FAM161 family | Protein lin-52 homolog; Lin-52 DREAM MuvB core complex component | 0.705 |
| FAM161B | LRRC74A | ENSP00000286544 | ENSP00000377369 | Protein FAM161B; Family with sequence similarity 161 member B; Belongs to the FAM161 family | Leucine-rich repeat-containing protein 74A; Leucine rich repeat containing 74A | 0.783 |
| FAM161B | MAP9 | ENSP00000286544 | ENSP00000310593 | Protein FAM161B; Family with sequence similarity 161 member B; Belongs to the FAM161 family | Microtubule-associated protein 9; Involved in organization of the bipolar mitotic spindle. Required for bipolar spindle assembly, mitosis progression and cytokinesis. May act by stabilizing interphase microtubules | 0.713 |
| FAM161B | PTGR2 | ENSP00000286544 | ENSP00000452280 | Protein FAM161B; Family with sequence similarity 161 member B; Belongs to the FAM161 family | Prostaglandin reductase 2; Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto- PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation (By similarity) | 0.699 |
| FAM161B | SDCCAG8 | ENSP00000286544 | ENSP00000355499 | Protein FAM161B; Family with sequence similarity 161 member B; Belongs to the FAM161 family | Serologically defined colon cancer antigen 8; Plays a role in the establishment of cell polarity and epithelial lumen formation (By similarity). May play a role in ciliogenesis; Bardet-Biedl syndrome associated | 0.660 |
| FAM161B | TACC3 | ENSP00000286544 | ENSP00000326550 | Protein FAM161B; Family with sequence similarity 161 member B; Belongs to the FAM161 family | Transforming acidic coiled-coil-containing protein 3; Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension. May be involved in the control of cell gr [...] | 0.629 |
| FCF1 | AREL1 | ENSP00000344393 | ENSP00000348714 | rRNA-processing protein FCF1 homolog; Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly | Apoptosis-resistant E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits apoptosis by ubiquitinating and targeting for degradation a number of proapoptotic proteins including DIABLO/SMAC, HTRA2 and SEPT4/ARTS which are released from the mitochondrion into the cytosol following apoptotic stimulation | 0.615 |
| FCF1 | FAM161B | ENSP00000344393 | ENSP00000286544 | rRNA-processing protein FCF1 homolog; Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly | Protein FAM161B; Family with sequence similarity 161 member B; Belongs to the FAM161 family | 0.713 |
| FCF1 | LIN52 | ENSP00000344393 | ENSP00000451812 | rRNA-processing protein FCF1 homolog; Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly | Protein lin-52 homolog; Lin-52 DREAM MuvB core complex component | 0.548 |
| FCF1 | LRRC74A | ENSP00000344393 | ENSP00000377369 | rRNA-processing protein FCF1 homolog; Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly | Leucine-rich repeat-containing protein 74A; Leucine rich repeat containing 74A | 0.758 |
| FCF1 | PTGR2 | ENSP00000344393 | ENSP00000452280 | rRNA-processing protein FCF1 homolog; Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly | Prostaglandin reductase 2; Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto- PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation (By similarity) | 0.549 |
