| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C9orf9 | TMBIM4 | ENSP00000298546 | ENSP00000286424 | Sperm acrosome-associated protein 9; Chromosome 9 open reading frame 9 | Transmembrane BAX inhibitor motif containing 4; Belongs to the BI1 family | 0.634 |
| DENND5B | KCNQ5 | ENSP00000373734 | ENSP00000345055 | DENN domain-containing protein 5B; Guanine nucleotide exchange factor (GEF) which may activate RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form; DENN/MADD domain containing | Potassium voltage-gated channel subfamily KQT member 5; Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. Therefore, it is important in the regulation of neuronal excitability. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M- channels, varying in kinetic and pharmacological properties, which underlie this physiologically important curren [...] | 0.565 |
| DENND5B | TACC3 | ENSP00000373734 | ENSP00000326550 | DENN domain-containing protein 5B; Guanine nucleotide exchange factor (GEF) which may activate RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form; DENN/MADD domain containing | Transforming acidic coiled-coil-containing protein 3; Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension. May be involved in the control of cell gr [...] | 0.606 |
| DENND5B | TMBIM4 | ENSP00000373734 | ENSP00000286424 | DENN domain-containing protein 5B; Guanine nucleotide exchange factor (GEF) which may activate RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form; DENN/MADD domain containing | Transmembrane BAX inhibitor motif containing 4; Belongs to the BI1 family | 0.621 |
| GHITM | TMBIM4 | ENSP00000361207 | ENSP00000286424 | Growth hormone-inducible transmembrane protein; Required for the mitochondrial tubular network and cristae organization. Involved in apoptotic release of cytochrome c; Transmembrane BAX inhibitor motif containing | Transmembrane BAX inhibitor motif containing 4; Belongs to the BI1 family | 0.627 |
| KCNH6 | TMBIM4 | ENSP00000463533 | ENSP00000286424 | Potassium voltage-gated channel subfamily H member 6; Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, rectifying current (By similarity). Channel properties may be modulated by cAMP and subunit assembly; Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.2/KCNH6 sub-subfamily | Transmembrane BAX inhibitor motif containing 4; Belongs to the BI1 family | 0.620 |
| KCNQ5 | DENND5B | ENSP00000345055 | ENSP00000373734 | Potassium voltage-gated channel subfamily KQT member 5; Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. Therefore, it is important in the regulation of neuronal excitability. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M- channels, varying in kinetic and pharmacological properties, which underlie this physiologically important curren [...] | DENN domain-containing protein 5B; Guanine nucleotide exchange factor (GEF) which may activate RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form; DENN/MADD domain containing | 0.565 |
| KCNQ5 | TACC3 | ENSP00000345055 | ENSP00000326550 | Potassium voltage-gated channel subfamily KQT member 5; Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. Therefore, it is important in the regulation of neuronal excitability. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M- channels, varying in kinetic and pharmacological properties, which underlie this physiologically important curren [...] | Transforming acidic coiled-coil-containing protein 3; Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension. May be involved in the control of cell gr [...] | 0.626 |
| KCNQ5 | TMBIM4 | ENSP00000345055 | ENSP00000286424 | Potassium voltage-gated channel subfamily KQT member 5; Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. Therefore, it is important in the regulation of neuronal excitability. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M- channels, varying in kinetic and pharmacological properties, which underlie this physiologically important curren [...] | Transmembrane BAX inhibitor motif containing 4; Belongs to the BI1 family | 0.629 |
| PREP | TMBIM4 | ENSP00000358106 | ENSP00000286424 | Prolyl endopeptidase; Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long; Belongs to the peptidase S9A family | Transmembrane BAX inhibitor motif containing 4; Belongs to the BI1 family | 0.731 |
| RCN2 | TMBIM4 | ENSP00000319739 | ENSP00000286424 | Reticulocalbin-2; Not known. Binds calcium; EF-hand domain containing | Transmembrane BAX inhibitor motif containing 4; Belongs to the BI1 family | 0.672 |
| SUOX | TMBIM4 | ENSP00000377668 | ENSP00000286424 | Sulfite oxidase, mitochondrial; Sulfite oxidase | Transmembrane BAX inhibitor motif containing 4; Belongs to the BI1 family | 0.620 |
| TACC3 | DENND5B | ENSP00000326550 | ENSP00000373734 | Transforming acidic coiled-coil-containing protein 3; Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension. May be involved in the control of cell gr [...] | DENN domain-containing protein 5B; Guanine nucleotide exchange factor (GEF) which may activate RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form; DENN/MADD domain containing | 0.606 |
| TACC3 | KCNQ5 | ENSP00000326550 | ENSP00000345055 | Transforming acidic coiled-coil-containing protein 3; Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension. May be involved in the control of cell gr [...] | Potassium voltage-gated channel subfamily KQT member 5; Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. Therefore, it is important in the regulation of neuronal excitability. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M- channels, varying in kinetic and pharmacological properties, which underlie this physiologically important curren [...] | 0.626 |
| TACC3 | TMBIM4 | ENSP00000326550 | ENSP00000286424 | Transforming acidic coiled-coil-containing protein 3; Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension. May be involved in the control of cell gr [...] | Transmembrane BAX inhibitor motif containing 4; Belongs to the BI1 family | 0.640 |
| TMBIM4 | C9orf9 | ENSP00000286424 | ENSP00000298546 | Transmembrane BAX inhibitor motif containing 4; Belongs to the BI1 family | Sperm acrosome-associated protein 9; Chromosome 9 open reading frame 9 | 0.634 |
| TMBIM4 | DENND5B | ENSP00000286424 | ENSP00000373734 | Transmembrane BAX inhibitor motif containing 4; Belongs to the BI1 family | DENN domain-containing protein 5B; Guanine nucleotide exchange factor (GEF) which may activate RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form; DENN/MADD domain containing | 0.621 |
| TMBIM4 | GHITM | ENSP00000286424 | ENSP00000361207 | Transmembrane BAX inhibitor motif containing 4; Belongs to the BI1 family | Growth hormone-inducible transmembrane protein; Required for the mitochondrial tubular network and cristae organization. Involved in apoptotic release of cytochrome c; Transmembrane BAX inhibitor motif containing | 0.627 |
| TMBIM4 | KCNH6 | ENSP00000286424 | ENSP00000463533 | Transmembrane BAX inhibitor motif containing 4; Belongs to the BI1 family | Potassium voltage-gated channel subfamily H member 6; Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, rectifying current (By similarity). Channel properties may be modulated by cAMP and subunit assembly; Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.2/KCNH6 sub-subfamily | 0.620 |
| TMBIM4 | KCNQ5 | ENSP00000286424 | ENSP00000345055 | Transmembrane BAX inhibitor motif containing 4; Belongs to the BI1 family | Potassium voltage-gated channel subfamily KQT member 5; Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. Therefore, it is important in the regulation of neuronal excitability. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M- channels, varying in kinetic and pharmacological properties, which underlie this physiologically important curren [...] | 0.629 |
