node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
COL9A2 | MATN3 | ENSP00000361834 | ENSP00000383894 | Collagen alpha-2(IX) chain; Structural component of hyaline cartilage and vitreous of the eye; Collagen proteoglycans | Matrilin-3; Major component of the extracellular matrix of cartilage and may play a role in the formation of extracellular filamentous networks; Matrilins | 0.723 |
COL9A2 | SLC26A2 | ENSP00000361834 | ENSP00000286298 | Collagen alpha-2(IX) chain; Structural component of hyaline cartilage and vitreous of the eye; Collagen proteoglycans | Sulfate transporter; Sulfate transporter. May play a role in endochondral bone formation; Solute carriers | 0.673 |
MATN3 | COL9A2 | ENSP00000383894 | ENSP00000361834 | Matrilin-3; Major component of the extracellular matrix of cartilage and may play a role in the formation of extracellular filamentous networks; Matrilins | Collagen alpha-2(IX) chain; Structural component of hyaline cartilage and vitreous of the eye; Collagen proteoglycans | 0.723 |
MATN3 | SLC26A2 | ENSP00000383894 | ENSP00000286298 | Matrilin-3; Major component of the extracellular matrix of cartilage and may play a role in the formation of extracellular filamentous networks; Matrilins | Sulfate transporter; Sulfate transporter. May play a role in endochondral bone formation; Solute carriers | 0.756 |
NDUFS7 | SLC26A2 | ENSP00000233627 | ENSP00000286298 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone | Sulfate transporter; Sulfate transporter. May play a role in endochondral bone formation; Solute carriers | 0.777 |
PAPSS1 | PAPSS2 | ENSP00000265174 | ENSP00000406157 | Bifunctional 3’-phosphoadenosine 5’-phosphosulfate synthase 1; Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5’-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3’-phosphoadenylylsulfate (PAPS- activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate- activation pathway. Required [...] | Bifunctional 3’-phosphoadenosine 5’-phosphosulfate synthase 2; Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5’-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3’-phosphoadenylylsulfate (PAPS- activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate- activation pathway. May have [...] | 0.928 |
PAPSS1 | SLC26A2 | ENSP00000265174 | ENSP00000286298 | Bifunctional 3’-phosphoadenosine 5’-phosphosulfate synthase 1; Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5’-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3’-phosphoadenylylsulfate (PAPS- activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate- activation pathway. Required [...] | Sulfate transporter; Sulfate transporter. May play a role in endochondral bone formation; Solute carriers | 0.702 |
PAPSS2 | PAPSS1 | ENSP00000406157 | ENSP00000265174 | Bifunctional 3’-phosphoadenosine 5’-phosphosulfate synthase 2; Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5’-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3’-phosphoadenylylsulfate (PAPS- activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate- activation pathway. May have [...] | Bifunctional 3’-phosphoadenosine 5’-phosphosulfate synthase 1; Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5’-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3’-phosphoadenylylsulfate (PAPS- activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate- activation pathway. Required [...] | 0.928 |
PAPSS2 | SLC26A2 | ENSP00000406157 | ENSP00000286298 | Bifunctional 3’-phosphoadenosine 5’-phosphosulfate synthase 2; Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5’-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3’-phosphoadenylylsulfate (PAPS- activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate- activation pathway. May have [...] | Sulfate transporter; Sulfate transporter. May play a role in endochondral bone formation; Solute carriers | 0.691 |
SLC13A1 | SLC26A2 | ENSP00000194130 | ENSP00000286298 | Solute carrier family 13 member 1; Sodium/sulfate cotransporter that mediates sulfate reabsorption in the kidney; Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily | Sulfate transporter; Sulfate transporter. May play a role in endochondral bone formation; Solute carriers | 0.798 |
SLC13A2 | SLC26A2 | ENSP00000392411 | ENSP00000286298 | Solute carrier family 13 member 2; Cotransport of sodium ions and dicarboxylates such as succinate and citrate; Solute carriers | Sulfate transporter; Sulfate transporter. May play a role in endochondral bone formation; Solute carriers | 0.775 |
SLC13A3 | SLC26A2 | ENSP00000279027 | ENSP00000286298 | Solute carrier family 13 member 3; High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-5 carbon atoms. The stoichiometry is probably 3 Na(+) for 1 divalent succinate; Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily | Sulfate transporter; Sulfate transporter. May play a role in endochondral bone formation; Solute carriers | 0.671 |
SLC13A4 | SLC26A2 | ENSP00000297282 | ENSP00000286298 | Solute carrier family 13 member 4; Sodium/sulfate cotransporter that mediates sulfate reabsorption in the high endothelial venules (HEV); Solute carriers | Sulfate transporter; Sulfate transporter. May play a role in endochondral bone formation; Solute carriers | 0.671 |
SLC26A2 | COL9A2 | ENSP00000286298 | ENSP00000361834 | Sulfate transporter; Sulfate transporter. May play a role in endochondral bone formation; Solute carriers | Collagen alpha-2(IX) chain; Structural component of hyaline cartilage and vitreous of the eye; Collagen proteoglycans | 0.673 |
SLC26A2 | MATN3 | ENSP00000286298 | ENSP00000383894 | Sulfate transporter; Sulfate transporter. May play a role in endochondral bone formation; Solute carriers | Matrilin-3; Major component of the extracellular matrix of cartilage and may play a role in the formation of extracellular filamentous networks; Matrilins | 0.756 |
SLC26A2 | NDUFS7 | ENSP00000286298 | ENSP00000233627 | Sulfate transporter; Sulfate transporter. May play a role in endochondral bone formation; Solute carriers | NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone | 0.777 |
SLC26A2 | PAPSS1 | ENSP00000286298 | ENSP00000265174 | Sulfate transporter; Sulfate transporter. May play a role in endochondral bone formation; Solute carriers | Bifunctional 3’-phosphoadenosine 5’-phosphosulfate synthase 1; Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5’-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3’-phosphoadenylylsulfate (PAPS- activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate- activation pathway. Required [...] | 0.702 |
SLC26A2 | PAPSS2 | ENSP00000286298 | ENSP00000406157 | Sulfate transporter; Sulfate transporter. May play a role in endochondral bone formation; Solute carriers | Bifunctional 3’-phosphoadenosine 5’-phosphosulfate synthase 2; Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5’-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3’-phosphoadenylylsulfate (PAPS- activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate- activation pathway. May have [...] | 0.691 |
SLC26A2 | SLC13A1 | ENSP00000286298 | ENSP00000194130 | Sulfate transporter; Sulfate transporter. May play a role in endochondral bone formation; Solute carriers | Solute carrier family 13 member 1; Sodium/sulfate cotransporter that mediates sulfate reabsorption in the kidney; Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily | 0.798 |
SLC26A2 | SLC13A2 | ENSP00000286298 | ENSP00000392411 | Sulfate transporter; Sulfate transporter. May play a role in endochondral bone formation; Solute carriers | Solute carrier family 13 member 2; Cotransport of sodium ions and dicarboxylates such as succinate and citrate; Solute carriers | 0.775 |