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STRINGSTRING
DSE DSE SART1 SART1 MAGEC1 MAGEC1 CTAG1A CTAG1A SSX4B SSX4B SAGE1 SAGE1 MAGEC2 MAGEC2 CTAG1B CTAG1B SSX2 SSX2 PASD1 PASD1 CTAG2 CTAG2
"MAGEC1" - Melanoma-associated antigen C1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MAGEC1Melanoma-associated antigen C1; MAGE family member C1 (1142 aa)    
Predicted Functional Partners:
PASD1
Circadian clock protein PASD1; Functions as a suppressor of the biological clock that drives the daily circadian rhythms of cells throughout the body. Acts as a nuclear repressor of the CLOCK- ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock components. Inhibits circadian clock function in cancer cells, when overexpressed (773 aa)
      
   
  0.891
CTAG1B
Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family (180 aa)
      
 
  0.858
CTAG1A
Cancer/testis antigen 1A; Belongs to the CTAG/PCC1 family (180 aa)
      
 
  0.845
MAGEC2
Melanoma-associated antigen C2; Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3-substrate complex; MAGE family (373 aa)
      
   
0.790
SAGE1
Sarcoma antigen 1 (904 aa)
      
   
  0.758
SART1
U4/U6.U5 tri-snRNP-associated protein 1; Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA; Belongs to the SNU66/SART1 family (800 aa)
            
  0.757
DSE
Dermatan-sulfate epimerase; Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues (958 aa)
            
  0.749
SSX2
Synovial sarcoma, X breakpoint 2; SSX family member 2 (223 aa)
      
   
  0.733
CTAG2
Cancer/testis antigen 2 (210 aa)
      
   
  0.720
SSX4B
Protein SSX4; Could act as a modulator of transcription (188 aa)
            
  0.700
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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