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STRINGSTRING
CCDC40 CCDC40 DYNC2LI1 DYNC2LI1 CFAP20 CFAP20 CCDC146 CCDC146 WDR90 WDR90 C4orf47 C4orf47 CCDC96 CCDC96 C7orf31 C7orf31 EFHC1 EFHC1 CCDC113 CCDC113 CCDC38 CCDC38
"CCDC146" - Coiled-coil domain containing 146 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
CCDC146Coiled-coil domain containing 146 (955 aa)    
Predicted Functional Partners:
C4orf47
UPF0602 protein C4orf47; Chromosome 4 open reading frame 47; Belongs to the UPF0602 family (309 aa)
            
  0.789
CFAP20
Cilia- and flagella-associated protein 20; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation (193 aa)
      
   
  0.779
CCDC40
Coiled-coil domain-containing protein 40; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC39 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella (By similarity). Not required for outer dynein arm complexes assembly. Required for axonemal recruitment of CCDC39; Belongs to the CCDC40 family (1142 aa)
      
   
  0.753
CCDC96
Coiled-coil domain containing 96 (555 aa)
      
   
  0.751
WDR90
WD repeat-containing protein 90; WD repeat domain containing (1748 aa)
      
   
  0.749
C7orf31
Uncharacterized protein C7orf31; Chromosome 7 open reading frame 31 (590 aa)
            
  0.710
CCDC38
Coiled-coil domain containing 38 (563 aa)
      
   
  0.692
CCDC113
Coiled-coil domain-containing protein 113; Component of centriolar satellites contributing to primary cilium formation (377 aa)
      
   
  0.636
EFHC1
EF-hand domain-containing protein 1; Microtubule-associated protein which regulates cell division and neuronal migration during cortical development. Necessary for mitotic spindle organization. Necessary for radial and tangential cell migration during brain development, possibly acting as a regulator of cell morphology and process formation during migration. May enhance calcium influx through CACNA1E and stimulate programmed cell death; EF-hand domain containing (640 aa)
      
   
  0.631
DYNC2LI1
Cytoplasmic dynein 2 light intermediate chain 1; Required for correct intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. Involved in the regulation of ciliary length; Dyneins, cytoplasmic (352 aa)
      
   
  0.626
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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