NIFK protein (human) - STRING database

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Score

NIFK

Nucleolar protein interacting with the FHA domain of MKI67; RNA binding motif containing (293 aa)

Predicted Functional Partners:

EBNA1BP2

0.998

FTSJ3

0.998

RPF2

0.998

MRTO4

0.998

BRIX1

0.998

RRS1

0.997

DDX18

0.997

NSA2

0.997

GNL3

0.997

NOP2

0.997

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRIX1	DDX18	ENSP00000338862	ENSP00000263239	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit	ATP-dependent RNA helicase DDX18; Probable RNA-dependent helicase; Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily	0.990
BRIX1	EBNA1BP2	ENSP00000338862	ENSP00000407323	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit	Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA; Belongs to the EBP2 family	0.998
BRIX1	FTSJ3	ENSP00000338862	ENSP00000396673	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit	pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily	0.985
BRIX1	GNL3	ENSP00000338862	ENSP00000395772	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit	Guanine nucleotide-binding protein-like 3; May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity); Belongs to the TRAFAC class YlqF/YawG GTPase family	0.949
BRIX1	MRTO4	ENSP00000338862	ENSP00000364320	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit	mRNA turnover protein 4 homolog; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes	0.996
BRIX1	NIFK	ENSP00000338862	ENSP00000285814	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit	Nucleolar protein interacting with the FHA domain of MKI67; RNA binding motif containing	0.998
BRIX1	NOP2	ENSP00000338862	ENSP00000371858	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit	Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase; Involved in ribosomal large subunit assembly. S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (Probable). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (Probable); Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family	0.994
BRIX1	NSA2	ENSP00000338862	ENSP00000483484	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit	Ribosome biogenesis protein NSA2 homolog; Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity)	0.994
BRIX1	RPF2	ENSP00000338862	ENSP00000402338	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit	Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus	0.989
BRIX1	RRS1	ENSP00000338862	ENSP00000322396	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit	Ribosome biogenesis regulatory protein homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus; Belongs to the RRS1 family	0.956
DDX18	BRIX1	ENSP00000263239	ENSP00000338862	ATP-dependent RNA helicase DDX18; Probable RNA-dependent helicase; Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily	Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit	0.990
DDX18	EBNA1BP2	ENSP00000263239	ENSP00000407323	ATP-dependent RNA helicase DDX18; Probable RNA-dependent helicase; Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily	Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA; Belongs to the EBP2 family	0.987
DDX18	FTSJ3	ENSP00000263239	ENSP00000396673	ATP-dependent RNA helicase DDX18; Probable RNA-dependent helicase; Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily	pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily	0.978
DDX18	GNL3	ENSP00000263239	ENSP00000395772	ATP-dependent RNA helicase DDX18; Probable RNA-dependent helicase; Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily	Guanine nucleotide-binding protein-like 3; May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity); Belongs to the TRAFAC class YlqF/YawG GTPase family	0.968
DDX18	MRTO4	ENSP00000263239	ENSP00000364320	ATP-dependent RNA helicase DDX18; Probable RNA-dependent helicase; Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily	mRNA turnover protein 4 homolog; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes	0.973
DDX18	NIFK	ENSP00000263239	ENSP00000285814	ATP-dependent RNA helicase DDX18; Probable RNA-dependent helicase; Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily	Nucleolar protein interacting with the FHA domain of MKI67; RNA binding motif containing	0.997
DDX18	NOP2	ENSP00000263239	ENSP00000371858	ATP-dependent RNA helicase DDX18; Probable RNA-dependent helicase; Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily	Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase; Involved in ribosomal large subunit assembly. S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (Probable). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (Probable); Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family	0.992
DDX18	NSA2	ENSP00000263239	ENSP00000483484	ATP-dependent RNA helicase DDX18; Probable RNA-dependent helicase; Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily	Ribosome biogenesis protein NSA2 homolog; Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity)	0.987
DDX18	RPF2	ENSP00000263239	ENSP00000402338	ATP-dependent RNA helicase DDX18; Probable RNA-dependent helicase; Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily	Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus	0.990
DDX18	RRS1	ENSP00000263239	ENSP00000322396	ATP-dependent RNA helicase DDX18; Probable RNA-dependent helicase; Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily	Ribosome biogenesis regulatory protein homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus; Belongs to the RRS1 family	0.942

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