• Version:
  • 11.0 [archived version]
STRINGSTRING
ISM1 ISM1 CORO1C CORO1C MST4 MST4 C3orf52 C3orf52 STK24 STK24 C4orf19 C4orf19 PDCD10 PDCD10 STK25 STK25 KATNBL1 KATNBL1 FAM219B FAM219B FAM221A FAM221A
"C4orf19" - Uncharacterized protein C4orf19 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
C4orf19Uncharacterized protein C4orf19; Chromosome 4 open reading frame 19 (314 aa)    
Predicted Functional Partners:
STK24
Serine/threonine-protein kinase 24; Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress- induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase- independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on ’Thr-442’ and sti [...] (443 aa)
       
      0.864
PDCD10
Programmed cell death protein 10; Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity); Belongs to the PDCD10 family (212 aa)
       
      0.860
MST4
Serine/threonine-protein kinase 26; Mediator of cell growth. Modulates apoptosis. In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily (416 aa)
       
      0.836
STK25
Serine/threonine-protein kinase 25; Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration (426 aa)
       
      0.826
CORO1C
Coronin-1C; May be involved in cytokinesis, motility, and signal transduction; Belongs to the WD repeat coronin family (527 aa)
           
  0.682
ISM1
Isthmin-1; Acts as an angiogenesis inhibitor; Belongs to the isthmin family (464 aa)
           
  0.677
FAM219B
Protein FAM219B; Family with sequence similarity 219 member B (198 aa)
           
  0.590
FAM221A
Protein FAM221A; Family with sequence similarity 221 member A; Belongs to the FAM221 family (298 aa)
           
  0.588
C3orf52
TPA-induced transmembrane protein; Chromosome 3 open reading frame 52 (250 aa)
           
  0.581
KATNBL1
KATNB1-like protein 1; Regulates microtubule-severing activity of KATNAL1 in a concentration-dependent manner in vitro (304 aa)
           
  0.546
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
Server load: low (1%) [HD]