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STRINGSTRING
ABI3 ABI3 ABI1 ABI1 DCAF4L2 DCAF4L2 LRRIQ3 LRRIQ3 ABI3BP ABI3BP TMEM255B TMEM255B KRBOX1 KRBOX1 ATP10B ATP10B LTBP3 LTBP3 CCDC80 CCDC80 LTBP2 LTBP2
"ABI3BP" - Target of Nesh-SH3 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ABI3BPTarget of Nesh-SH3; Fibronectin type III domain containing (1075 aa)    
Predicted Functional Partners:
ABI3
ABI gene family member 3; May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility; Belongs to the ABI family (366 aa)
        
 
  0.975
ABI1
Abl interactor 1; May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recrui [...] (508 aa)
            
  0.645
TMEM255B
Transmembrane protein 255B (326 aa)
      
   
  0.536
KRBOX1
KRAB box domain containing 1 (128 aa)
            
  0.533
LTBP3
Latent-transforming growth factor beta-binding protein 3; May be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extracellular matrix (ECM); Belongs to the LTBP family (1303 aa)
      
   
  0.503
ATP10B
Probable phospholipid-transporting ATPase VB; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable); Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily (1461 aa)
            
  0.498
LRRIQ3
Leucine rich repeats and IQ motif containing 3 (624 aa)
            
  0.487
CCDC80
Coiled-coil domain-containing protein 80; Promotes cell adhesion and matrix assembly (950 aa)
      
   
  0.483
DCAF4L2
DDB1- and CUL4-associated factor 4-like protein 2; DDB1 and CUL4 associated factor 4 like 2; WD repeat domain containing (395 aa)
            
  0.473
LTBP2
Latent-transforming growth factor beta-binding protein 2; May play an integral structural role in elastic-fiber architectural organization and/or assembly; Latent transforming growth factor beta binding proteins (1821 aa)
      
   
  0.462
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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