• Version:
  • 11.0 [archived version]
STRINGSTRING
OPALIN OPALIN IQCJ IQCJ NGRN NGRN GAP43 GAP43 NRGN NRGN BSX BSX CALM1 CALM1 PCP4 PCP4 PRKCG PRKCG PVALB PVALB ZNF804A ZNF804A
"NRGN" - Neurogranin in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
NRGNNeurogranin; Acts as a "third messenger" substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity); Belongs to the neurogranin family (78 aa)    
Predicted Functional Partners:
CALM1
Calmodulin-1; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Mediates calcium-dependent inactivation of CACNA1C. Positively regulates calcium-activated potassium channel activity of KCNN2 (149 aa)
     
 
  0.805
OPALIN
Opalin; Oligodendrocytic myelin paranodal and inner loop protein (141 aa)
     
   
  0.766
ZNF804A
Zinc finger protein 804A (1209 aa)
     
   
  0.737
NGRN
Neugrin; May be involved in neuronal differentiation (291 aa)
           
  0.708
GAP43
Neuromodulin; This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction (274 aa)
     
   
  0.706
PCP4
Calmodulin regulator protein PCP4; Functions as a modulator of calcium-binding by calmodulin. Thereby, regulates calmodulin activity and the different processes it controls. For instance, may play a role in neuronal differentiation through activation of calmodulin-dependent kinase signaling pathways; Belongs to the PCP4 family (62 aa)
     
   
  0.666
PRKCG
Protein kinase C gamma type; Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing pl [...] (697 aa)
     
 
  0.652
IQCJ
IQ motif containing J (159 aa)
           
  0.650
PVALB
Parvalbumin alpha; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions; EF-hand domain containing (110 aa)
     
 
  0.643
BSX
Brain-specific homeobox protein homolog; DNA binding protein that function as transcriptional activator. Is essentiel for normal postnatal growth and nursing. Is an essential factor for neuronal neuropeptide Y and agouti- related peptide function and locomotory behavior in the control of energy balance (By similarity); NKL subclass homeoboxes and pseudogenes (233 aa)
           
  0.641
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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