node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C16orf74 | COX4I1 | ENSP00000284245 | ENSP00000457513 | Uncharacterized protein C16orf74; Chromosome 16 open reading frame 74 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial; This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport | 0.617 |
C16orf74 | DPM2 | ENSP00000284245 | ENSP00000322181 | Uncharacterized protein C16orf74; Chromosome 16 open reading frame 74 | Dolichol phosphate-mannose biosynthesis regulatory protein; Regulates the biosynthesis of dolichol phosphate- mannose. Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1. When associated with the GPI-GlcNAc transferase (GPI-GnT) complex enhances but is not essential for its activity | 0.554 |
C16orf74 | EMC8 | ENSP00000284245 | ENSP00000253457 | Uncharacterized protein C16orf74; Chromosome 16 open reading frame 74 | ER membrane protein complex subunit 8 | 0.828 |
C16orf74 | GINS2 | ENSP00000284245 | ENSP00000253462 | Uncharacterized protein C16orf74; Chromosome 16 open reading frame 74 | DNA replication complex GINS protein PSF2; The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single- stranded DNA | 0.722 |
C16orf74 | GSE1 | ENSP00000284245 | ENSP00000253458 | Uncharacterized protein C16orf74; Chromosome 16 open reading frame 74 | Genetic suppressor element 1; Gse1 coiled-coil protein | 0.804 |
C16orf74 | KCTD11 | ENSP00000284245 | ENSP00000328352 | Uncharacterized protein C16orf74; Chromosome 16 open reading frame 74 | BTB/POZ domain-containing protein KCTD11; Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. Functions as antagonist of t [...] | 0.480 |
C16orf74 | NLRP3 | ENSP00000284245 | ENSP00000337383 | Uncharacterized protein C16orf74; Chromosome 16 open reading frame 74 | NACHT, LRR and PYD domains-containing protein 3; As the sensor component of the NLRP3 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP3, PYCARD and CASP1 (and possibly CASP4 and CASP5). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1- catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP3 inflammasome is also required for HMGB1 secretion. The active cytoki [...] | 0.518 |
C16orf74 | PPP3CA | ENSP00000284245 | ENSP00000378323 | Uncharacterized protein C16orf74; Chromosome 16 open reading frame 74 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase. Many of the substrates contain a PxIxIT motif. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1; Belongs to the PPP phosphatase family. PP-2B subfamily | 0.829 |
C16orf74 | TNS4 | ENSP00000284245 | ENSP00000254051 | Uncharacterized protein C16orf74; Chromosome 16 open reading frame 74 | Tensin-4; May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton (By similarity). May promote apoptosis, via its cleavage by caspase-3; SH2 domain containing | 0.555 |
C16orf74 | UNC119 | ENSP00000284245 | ENSP00000337040 | Uncharacterized protein C16orf74; Chromosome 16 open reading frame 74 | Protein unc-119 homolog A; Involved in synaptic functions in photoreceptor cells, the signal transduction in immune cells as a Src family kinase activator, endosome recycling, the uptake of bacteria and endocytosis, protein trafficking in sensory neurons and as lipid- binding chaperone with specificity for a diverse subset of myristoylated proteins. Specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated GNAT1 and is required for G-protein localization and trafficking in sensory neurons. Prob [...] | 0.787 |
COX4I1 | C16orf74 | ENSP00000457513 | ENSP00000284245 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial; This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport | Uncharacterized protein C16orf74; Chromosome 16 open reading frame 74 | 0.617 |
COX4I1 | EMC8 | ENSP00000457513 | ENSP00000253457 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial; This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport | ER membrane protein complex subunit 8 | 0.914 |
COX4I1 | GINS2 | ENSP00000457513 | ENSP00000253462 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial; This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport | DNA replication complex GINS protein PSF2; The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single- stranded DNA | 0.479 |
COX4I1 | GSE1 | ENSP00000457513 | ENSP00000253458 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial; This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport | Genetic suppressor element 1; Gse1 coiled-coil protein | 0.632 |
DPM2 | C16orf74 | ENSP00000322181 | ENSP00000284245 | Dolichol phosphate-mannose biosynthesis regulatory protein; Regulates the biosynthesis of dolichol phosphate- mannose. Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1. When associated with the GPI-GlcNAc transferase (GPI-GnT) complex enhances but is not essential for its activity | Uncharacterized protein C16orf74; Chromosome 16 open reading frame 74 | 0.554 |
DPM2 | KCTD11 | ENSP00000322181 | ENSP00000328352 | Dolichol phosphate-mannose biosynthesis regulatory protein; Regulates the biosynthesis of dolichol phosphate- mannose. Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1. When associated with the GPI-GlcNAc transferase (GPI-GnT) complex enhances but is not essential for its activity | BTB/POZ domain-containing protein KCTD11; Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. Functions as antagonist of t [...] | 0.429 |
DPM2 | TNS4 | ENSP00000322181 | ENSP00000254051 | Dolichol phosphate-mannose biosynthesis regulatory protein; Regulates the biosynthesis of dolichol phosphate- mannose. Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization and stable expression of DPM1. When associated with the GPI-GlcNAc transferase (GPI-GnT) complex enhances but is not essential for its activity | Tensin-4; May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton (By similarity). May promote apoptosis, via its cleavage by caspase-3; SH2 domain containing | 0.416 |
EMC8 | C16orf74 | ENSP00000253457 | ENSP00000284245 | ER membrane protein complex subunit 8 | Uncharacterized protein C16orf74; Chromosome 16 open reading frame 74 | 0.828 |
EMC8 | COX4I1 | ENSP00000253457 | ENSP00000457513 | ER membrane protein complex subunit 8 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial; This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport | 0.914 |
EMC8 | GINS2 | ENSP00000253457 | ENSP00000253462 | ER membrane protein complex subunit 8 | DNA replication complex GINS protein PSF2; The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single- stranded DNA | 0.781 |